Attachment 1 - Purchase Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: The National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) Neuronal Circuits and Behavior Section (NCBS) of the Cellular Neurobiology Research Branch (CNRB) is in need of procuring a Stereotaxic Alignment Instrument from David Kopf Instruments (brand name or equal) for their ongoing work investigating neuronal circuits that contribute to opioid use disorder and natural/motivated behaviors such as feeding and fight-or-flight.

2. Background Information and Objective: The NIDA IRP Mission is to conduct state-of-the-art basic, preclinical and clinical research on mechanisms that underlie substance use disorders, addiction and relapse. Ultimately we hope to translate these efforts into new methods for the prevention and treatment of substance use disorders highlighting the following: enhancing our research by taking advantage of our unique and outstanding strengths; increasing translational research and fortifying our clinical portfolio; strengthening our basic science with investment in technology; increasing Diversity and Inclusion at all levels; and prioritizing Trans-NIH initiatives and growing strong ties with other institutes.

The NCBS of the CNRB uses a combination of state-of-the-art optogenetic, electrophysiology, two-photon fluorescence endomicroscopy, immunohistochemistry, and behavioral assays to elucidate the neuronal basis of survival behaviors, such as feeding, and determine how these behaviors are disrupted in eating disorders and drug addiction.

The NCBS has a need to procure a David Kopf Instruments Stereotaxic Alignment Instrument to precisely and accurately target discrete brain regions that can be difficult to target by traditional surgical frames. Increasing accuracy for difficult injection targets is desirable, because it decreases the total number of animals needed for an experiment. In particular, work by the NCBS requires targeting of mouse deep brain regions for BSL2 anatomical tracing studies that are difficult to accurately hit with existing equipment. In addition, this Stereotaxic Alignment Instrument is compatible with both mouse and rat procedures, and this frame will be available for use by any NIDA IRP investigator working with BSL2 reagents in rodents.

3. Generic Name of Product: Stereotaxic Alignment Instrument

4. Purchase Description: The Government requires the following brand name or equal product – David Kopf Instruments Sterotaxic Alignment Instrument (Model 1900). It shall consist of the following items.

• Model 1900 Stereotaxic Alignment Instrument (includes stereotaxic head holder assembly with sagittal platel; Model 1923-B Mouse Gas Anesthesia Head Holder;

and Model 1922 Non-Rupture 60 degree Tip Mouse Ear Bars)

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

• Digital Manipulator 1 Micron 3-Axis Display Console (Model 1940)

• Alignment Indicator (Model 1905)

• Dial Test Indicator (Model 1910)

• Drill (Model 1911)

• Scope (Model 1915)

• Rat Gas Anesthesia Adaptor (Model 1929-B)

• 45 Degree Tip Non-Rupture Ear Bar (Model 1955)

• Syringe Holder (Model 1972)

• Syringe Pump Adapter (Model 1972)

• Adjustable Stage Platform (Model 1901)

This product shall include shipping.

5. Salient characteristics: The NIDA IRP CNRB requires one (1) Stereotaxic Alignment Instrument that meets the following brand name or equal characteristics:

• Enables precise alignment of electrodes to within fractions of a millimeter.

• Robust and stable, minimizing unwanted movement during surgical procedures.

• Modular design that allows flexibility in accommodating different sized rats/mices and brain sizes.

• Compatible with various accessories such as electrode holders, cannulas, and microdrives.

• Provides precise system for measuring the position of electrodes or other relative anatomical landmarks in the brain.

• User-friendly and easy to operate. Intuitive controls and adjustable mechanisms that simplify the alignment process, reducing the potential for errors.

6. Quantity: 1 of each item described in Section 4.

7. Delivery Date: Desired delivery date after receipt of order is 6 weeks.

8. Delivery Location: 251 Bayview Boulevard, Suite 200, BRC 07A025, Baltimore, MD 21224. The POC for this delivery is Sarah Sarsfield (sarah.sarsfield@nih.gov).

9. Period of Performance: Contractor shall warrant that the Equipment will be free from material defects for a period of twelve (12) months from the date of delivery. All service performed on this equipment shall be provided by certified and factory trained technicians. Technicians shall have the ability to diagnose the systems on site via remote access. Contractor shall provide any required replacement components due to malfunctions on-site. All travel and labor necessary to repair the instrument and all parts are provided by the vendor at no cost to the customer.