Attachment 1-Purchase Description.pdf
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- Advanced Synthesis Workstation with selected probes, accessories, and service related to COVID-19 research
- Solicitation number
- CSS_75N95022Q00350
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Purchase Description Statement of Need and Purpose:
Background Information and Objective:
Generic Name of Product:
Purchase Description:
Salient Characteristics:
Quantity:
Delivery Date:
Period of Performance:
Option(s):
9.0.0.2.20101008.1.734229
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| Include a general narrative of the need of the requirement and the desired results.: This requisition is to purchase an Advanced Synthesis Workstation with selected probes, accessories, and service for the Biological & Chemical Development Group within Therapeutic Development Branch (TDB) in Division of Pre-Clinical with Innovation (DPI) at NCATS. |
| Include a brief history of the requirement, the importance of the requirement, and the overall program objectives.: Process Analytical Technology (PAT) is a manufacturing methodology for high value chemicals and pharmaceuticals. PAT measures key quality and performance indicators in raw materials, in-process materials and processes in real-time. A well designed PAT-based process is stable, ensuring that the critical parameters and indicators remain within pre-described limits to ensure product quality and process safety. PAT is applicable to many standard operations performed in chemical processes, including reaction monitoring and crystallization procedures. |
The system with selected probes can precisely control the reaction parameters such as temperature, pressure, airflow, pH, and provide the real time inline/online analytical results on the reaction transformation, particle size and in-situ imaging, and fundamentals of the thermochemistry and kinetics of a reaction. With more projects coming from the APP program, the system will help us to accelerate process development work and identify the critical quality contributors for a process. The benefits of incorporating this equipment include, improved product quality and uniformity, process cost reduction, enhanced process and product safety, eliminates/minimizes product re-work, speeds process cycle, facilitates regulatory acceptance and compliance, and overall creates a robust process that results in manufacturing of product that is right the first time.
| Specify the generic name of the component or system, e.g., freezer, microscope, cell sorter, etc.: Advanced Synthesis Workstation |
| Specify 1) trade name; 2) product’s brand name; 3) manufacturer's name; 4) model, type, catalog, and/or part number(s.): Advanced Synthesis Workstation for Chemical and Process Development with probes, accessories, and service. |
| Specify the significant, essential physical, functional, performance, or material element(s) (the distinguishing characteristic) of a product, system, component, or service required. Specify the functions that a system or component must perform to meet the Government’s objectives. Include required levels of performance, features or characteristics of the system or component that are essential to meet the government’s objectives. Specify the Government’s minimum acceptable standards.: |
1. Allows users to control a broad range of reaction parameters, such as temperature, pH, stirring speed or reagent addition with high precision;
2. All experimental data is recorded automatically, and can be evaluated further and exported into other applications;
3. Capability to incorporate in-line reaction monitor probes i.e. IR and in situ calorimetry;
4. Incorporates touchscreen to allow for reaction parameters to be controlled and data and trends displayed.
5. Ability to program for over 24 hour control of temperature, dosing, pH, and mixing.
6. A task sequence programmed on the touchscreen to enable unattended operation.
7. Ability to run reactions and crystallizations at any temperature from -40°C to 180°C without an ice bath or cryostat.
8. Overhead stirring
9. Dimensions and weight suitable to allow for benchtop useage: (WxDxH) 42 x 36 x 28 cm, 20KG
| Specify quantity. : Qty 1-Advanced Synthesis Workstation bundle 1 and 2 |
| Specify desired delivery date after receipt of order (30-60 days.): 30 work days after receipt of this award. |
| Specify period of performance for software license, warranty, or maintenance agreements.: Installation and first year warranty and service coverage and support on system, probes, and software. |
| Specify if options for additional quantities or options to extend the term of the contract for service agreements.: 2nd and 3rd year maintenance plan on equipment. |
File details come from the government source that posted it. Updated .