Attachment 1 -PET CT Product Description (PD).pdf

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Institute of Mental Health, Molecular Imaging Branch requests to purchase a PET/CT scanner for the non-human primate PET (Positron Emission Tomography) imaging program.

2. Background Information and Objective:

Animal models play an important role in the translational research for drug development.

The mission of Molecular Imaging Branch is to develop various imaging probes for the brain to study psychiatric disorders in human. The efficacy of all novel radiotracers will have to be tested in vivo in animals before they get applied to human.

The Molucular Imaging Branch acquired two microPET Focus preclinical scanner in 2006. Both scanners have reached their end of life as the vendor will discontinue their support to all microPET scanners by December 31, 2020. In order to continue our research mission, the Molecular Imaging Branch seeks to acquire a human PET/CT scanner to replace the Focuses.

With the technology advance, current human PET/CT scanners have more than adequate resolution to image nonhuman primates, as the Molecular Imaging Branch has already been using the human PET/CT in Clinical Center PET Department to perform whole body monkey scans for the past few years. Because of the high demands for human studies and concerns about cross species contamination in the PET Department, it is recommended that we obtain our own scanner for the animal imaging program, continuing the same set-up.

3. Generic Name of Product:

PET/CT scanner

4. Purchase Description:

• PET/CT scanner

• Five additional years extended warranty in addition to the one-year standard warranty which comes with the purchase

• A software upgrade that includes dynamic list mode acquisition and retrospective histogramming which allows flexible manipulation of the dynamic data

5. Salient characteristics

1. The PET scanner shall have a transaxial field-of-view (FOV) of ~ 70 cm or larger and an axial FOV > 15 cm.

2. The bed shall be able to handle patient load up to 225 kg with table speed range 0.1- 200 mm/sec and positioning accuracy < 0.5 mm.

3. The PET scanner shall use fast detector materials such as the LSO scintillator with coincidence time window < 5 nsec.

4. The PET scanner shall support static as well as multiple bed acquisition in 3D for whole body imaging.

5. The PET scanner shall support time-of-flight (TOF) acquisition with timing resolution < 600 psec.

6. The PET scanner shall be able to run two simultaneous reconstruction (e.g., AC and NAC) while acquiring data.

7. The PET scanner shall include a 3D image-based scatter correction.

8. The PET scanner shall include Fourier rebinning (FORE) + filtered back projection (FBP) for fast image reconstruction.

9. The PET scanner shall offer 3D iterative reconstruction (e.g., OSEM) to push for higher image resolution.

10. The PET scanner is required to achieve: 1) a transverse resolution (FWHM) of ~ 4 mm at the center of FOV and ~ 5 mm at 10 cm from the axial center; 2) an axial resolution (FWHM) of ~ 5 mm at the center of FOV and ~ 6 mm at 10 cm from the axial center; and 3) a slice thickness of 2 mm or less.

11. The PET scanner should achieve a sensitivity of > 6 cps/kBq. Peak NEC and peak true rate should be > 90 kcps (@ < 26 kBq/cc) & > 310 kcps (@ < 53 kBq/cc);

Effective sensitivity, effective peak NEC and effective peak true rate should be > 16 cps/kBq, > 220 kcps (@ < 26 kBq/cc) and > 780 kcps (@ < 53 kBq/cc) respectively.

12. Reconstruction time for 3D-OSEM per bed position (180x180 matrix, 81 plnes) shall be faster than 20 sec without TOF information and 25 sec with TOF information.

13. The PET scanner shall support dynamic acquisition that includes:

• list mode acquisition, offline histogramming and reconstruction

• retrospective histogramming in any arbitrary frame durations of 3 sec or greater

• maximum of 100 frames defined by available disk space

• whole body (multi-bed) dynamic support of up to 25 passes.

• the ability to reconstruct and sum multiple passes to generate a static image

• PET dynamic speed function which provides online replay/reconstruction capabilities during list mode acquisition, improving dynamic imaging throughput

14. High performance CT shall have a scan field of 70 cm or larger, be capable of acquiring 16 or more slices per rotation with rotation time of 1.5 sec or less – completing a whole-body scan of rhesus macaque with 1 mm slice thickness in < 1 min (image reconstructed).

15. Typical CT image uniformity shall be ± 2 HU ( ± 4 HU max.).

16. The system shall support, both CT & PET, DICOM image viewer and export.

17. Training shall include at least 32 hours of onsite training after the installation of the

PET/CT.

18. Contractor shall include an acceptance test following The National Electrical Manufacturers Association performance standard by an independent inspector.

6. Quantity:

One (1) PET/CT scanner

7. Delivery: The contractor shall deliver and install the equipment within 270 days after receipt of order. The equipment shall be delivered and installed in coordination with the Contracting Officer’s Representative (COR). The contractor shall provide certified and factory trained technicians to perform on-site setup and installation, the equipment shall be delivered and installed at 49/B1A67, Convent Drive, Bethesda, MD 20814 between the hours of 8:00am and 5:00pm, Bethesda Md Eastern Standard Time

8. Training:

Contractor shall provide a 4-day on-site training session for staff members within two (2) weeks of equipment installation or when requested by the COR. Training shall be arranged in coordination with the Contracting Officer’s Representative (COR). The contractor shall provide certified and factory trained technicians for on-site training.

9. Warranty/Service:

Contractor shall warrant the equipment for six (6) years covering parts and labor as follow;

• Standard warranty for a minimum of twelve (12) months from the date of acceptance at no additional cost.

• Options for Extended service warranty for a period of sixty (60) months following the standard warranty.

Standard warranty and extend service warranty shall include software upgrades, yearly on-site service maintenance. All services performed on the equipment shall be provided by certified and factory trained technicians.

10. Government’s Responsibilities

Government shall remove current equipment before installation

11. Period of Performance: Six (6) years as follow;

• Base Period – Standard warranty

• Five (5) Option Periods -Extended warranty coverage for services and maintenance support.

12. Options: Five (5) Option Periods for extended warranty coverage for service and maintenance support.