Attachment 1 PD_Tecan_CustomEVO150_PD_LC220201002401.pdf

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Purchase Description Statement of Need and Purpose:

Background Information and Objective:

Generic Name of Product:

Purchase Description:

Salient Characteristics:

Quantity:

Delivery Date:

Period of Performance:

Option(s):

9.0.0.2.20101008.1.734229

The concepts of throughput and cycle time are of great significance to translational scientists as they endeavor to increase experimental capacity while reducing the therapeutic discovery and development timeline in an effort to rapidly bring more treatments to patients. The development of an efficient method for the transfer of compounds from Medicinal Chemistry to Compound Management (CoMa) enables a faster turnaround between small molecule synthesis and biological assays. The compound workflow consists of 5 stages (synthesis, purification, processing, registration, and storage) each comprised of multiple steps. The ACC is responsible for purification, processing, and registration and has created the SMART Centralized Sample Purification and Processing Platform where internally synthesized compounds progress from sample submission to CoMa in only 5 days (2 days for purification, 2 days for processing, and 1 day for registration). The rationale is that by having the ACC conduct the majority of sample purifications the medicinal chemists are afforded more time to focus on synthesizing compounds and thus establishing a streamlined compound synthesis workflow, which is more efficient and productive.

Column chromatography is a single-sample-at-a-time process often making purification a major bottleneck in the medicinal chemistry pipeline. Despite this fixed parameter, advancements can be made with instrumentation, automation, methods development, and systems integration to create the most efficient purification workflow possible. The ACC has designed the FluidCore automated purification system as our solution for the technological problem of sample throughput. The ACC worked with Tecan on the design and development of an innovative and custom sample management and fraction collection platform built around the Tecan Freedom EVO150 liquid handling system. This custom Tecan Freedom EVO150 utilizes a dual arm fraction collection bed capable of accommodating a wide range of sample vessels, which can be arranged in a variety of configurations. The FluidCore system consists of the custom Tecan Freedom EVO150 platform connected with Waters analytical and purification LC instrumentation creating a single platform for automated purification. By developing the FluidCore automated purification system, current manual steps of the workflow will be replaced with automated protocols. The integrated Waters analytical UPLC-MS will be used to analyze pre-purification samples for automated method development. The Waters preparative LCMS will then use this method for purification of the sample where individual fractions are dispensed into containers on the custom Tecan Freedom EVO150 fraction collection bed followed by automated fraction analysis by the analytical UPLC-MS. Performance of all these processes within the same platform in an automated fashion will improve operational efficiency and reduce the cycle time for a compound to go from synthesis to plating in an effort to accelerate the drug discovery process. The custom Tecan Freedom EVO150 liquid handling platform is required as it is the core component of the ACC FluidCore automated purification system.

1. us10294 - LCMS Purification EWS

With the following custom configuration:

a. Freedom EVO150

i. 10641150 - Freedom EVO 150 Base Unit, includes 1 year warranty; QTY: 1

ii. 10643121 - Deck, 150, Stainless Steel; QTY: 1

iii. 30097461 - Safety Shield Set, Closed, Freedom EVO 150, Grey; QTY: 1

iv. 10619674 - System Liquid Container, 30L; QTY: 2

v. 10619820 - Waste Liquid Container, 30L, Freedom EVO; QTY: 2

vi. CER - Cutout for waste chute; QTY: 1

b. Arm #1- 8-Channel Liquid Handling Arm

i. 10642102 - Liquid Handling Arm (LiHa), 8-tip; QTY: 1

ii. 30019983 - Tubing, Interconnect, required for each Liquid Channel; QTY: 8

iii. 30019982 - Tubing, Pipette, Standard Volume, FEP, 2.5mm x 1.5mm, Length 3.1M; QTY: 8

iv. 10619426 - Syringe, 2500μL, XP diluters, flat cap; QTY: 8

v. 30029016 - FastWash Dual Pump, Upgrade Kit, Standard Tubing, 2 LiHa System; QTY: 1

vi. 10613001 - Wash Station, LiHa, Standard, Freedom EVO; QTY: 1

vii. 10643050 - Tip, Standard, Non-adjustable, PTFE Coated, includes Lock Nut; QTY: 4

viii. 30019984 - Disposable Tip Cone Assembly, Standard; QTY: 4

c. Arm #2- 8-Channel Liquid Handling Arm

i. 10642005 - Second Liquid Handling Arm (LiHa), 8-tip; QTY: 1

ii. 30019983 - Tubing, Interconnect, required for each Liquid Channel; QTY: 8

iii. 30019982 - Tubing, Pipette, Standard Volume, FEP, 2.5mm x 1.5mm, Length 3.1M; QTY: 8

iv. 10619426 - Syringe, 2500μL, XP diluters, flat cap; QTY: 8

v. 10613001 - Wash Station, LiHa, Standard, Freedom EVO; QTY: 1

vi. 10643050 - Tip, Standard, Non-adjustable, PTFE Coated, includes Lock Nut; QTY: 4

vii. 30019984 - Disposable Tip Cone Assembly, Standard; QTY: 4

d. Robotic Gripper Arm

i. 30013045 - Robotic Manipulator Arm (RoMa), extended z-rail; QTY: 1

ii. 30017037 - RoMa Fingers, Standard Length, set of 2; QTY: 1

iii. CER - Deck Cut Out; QTY: 1

iv. CER - Shelf on deck for tube racks; QTY: 1

e. Diluter, Valve and Tubing for LCMS Loading

i. CER - Diluter; QTY: 2

ii. CER - Valve System; QTY: 2

iii. CER - Tubing; QTY: 2

iv. CER - Control Board; QTY: 2

f. Vacuum for Tube Evacuation

i. 30119213 - US Valve Isolation 2-Way; QTY: 2

ii. 30045068 - Vacuum Pump, Chemically Resistant, Te-VacS External Vacuum Option; QTY: 2

iii. 30098066 - Silencer for KNF Vacuum Pump; QTY: 2

iv. 30031385 - Bottle Set, Standard, for Vacuum Filtration, HydroFlex; QTY: 1

v. CER - Tubing and Fittings; QTY: 1

g. Robotic Gripper Arm

i. 30013045 - Robotic Manipulator Arm (RoMa), extended z-rail; QTY: 1

ii. 30017037 - RoMa Fingers, Standard Length, set of 2; QTY: 1

iii. CER - Deck Cut Out; QTY: 1

iv. CER - Shelf on deck for tube racks; QTY: 1

h. Diluter, Valve and Tubing for LCMS Loading

i. CER - Diluter; QTY: 2

ii. CER - Valve System; QTY: 2

iii. CER - Tubing; QTY: 2

iv. CER - Control Board; QTY: 2

i. Six Way Valve and Dispenser for Flasks

i. 30079442 - Valve, 6-Way, Large Volume; QTY: 1

ii. 30012177 - Tubing, 6-Way Valve; QTY: 1

iii. CER - Dispenser system for flasks; QTY: 1

j. Computer and Software

i. 10615150 - EVOware Standard Software, EVO 100, 150, and 200; QTY: 1

ii. 30158027 - Computer, Desktop, Windows 10 Professional; QTY: 1

iii. 30123658 - Monitor, Touchscreen, LCD, Planar; QTY: 1

iv. 30024944 - Keyboard and Mouse, Wireless; QTY: 1

v. CER - Virscidian Driver for HPLC control and analysis; QTY: 1

vi. CER - LCMS EVOware Driver; QTY: 1

vii. CER - SPT Labtech Receiver Driver; QTY: 1

k. Worktable Carriers

i. 30097475 - DiTi Carrier , LiHa, 3-Position with Waste Site, includes DiTi Waste Chute and Cover, Silver; QTY: 1

ii. 30013061 - Microplate Carrier, 4-Position, Landscape, Low Profile; QTY: 6

iii. CER - MTP Tube Racks; QTY: 24

iv. CER - Flask locator under x rail; QTY: 1

v. CER - Mounting and access for SPT Labtech Receiver rear and left side; QTY: 2

2. 30001582 - Installation & Software Overview

a. LW Labwerx In-house setup, testing, acceptance testing, installation

3. 30001572 - Shipping and Handling