PHO - ARPA-H-SN-24-103.pdf

ARPA-H-SN-24-103

SPECIAL NOTICE:

PROACTIVE HEALTH OFFICE (PHO)

INNOVATIVE SOLUTIONS OPENING (ISO)

VIRTUAL PROPOSERS’ DAY

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH

PROACTIVE HEALTH OFFICE

SPECIAL NOTICE (SN): ARPA-H-SN-24-103

OPPORTUNITY ARPA-H PROACTIVE HEALTH OFFICE

EVENT Proactive Health Office Innovative Solutions Opening Virtual Proposers’ Day

EVENT DATE 2PM ET ON April 9th, 2024

REGISTRATION DEADLINE 5PM ET on April 5th, 2024

REGISTRATION WEBSITE https://solutions.arpa-h.gov/PHO

REGISTRATION POC arpa-h_pho_iso@arpa-h.gov

TECHNICAL POC Wade Shen, Director, Proactive Health Office

PROPOSERS’ DAY

The Advanced Research Projects Agency for Health (ARPA-H) is hosting a virtual Proposers’ Day in support of the Proactive Health Office (PHO) Innovative Solutions Opening (ISO). The virtual Proposers’ Day will be held on Tuesday, April 9th, 2024, from 2:00pm to 3:00pm Eastern Time (ET). Advance registration is required (registration link:

https://solutions.arpa-h.gov/PHO).

PROPOSERS’ DAY GOALS

1. Introduce the ARPA-H PHO goals and vision to the research community.

2. Clarify the logistics of an ARPA-H program generally as well as PHO-specific objectives.

3. Review and collect relevant questions which will be maintained in a frequently asked questions (FAQ) document available on the ARPA-H website (https://arpa-h.gov/).

BACKGROUND ON THE ARPA-H PROACTIVE HEALTH OFFICE

Despite huge advances in the development of novel medical therapies, Americans still live with poor health outcomes and suffer from the ill-effects of disease. Current medical research and the medical delivery system in the United States focus primarily on the reactive treatment of illnesses, despite the fact that many diseases or their ill-effects are preventable.

The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that

1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of Americans throughout their lives, and 3) that system-level innovations are required for delivery of proactive health effectively.

Interested parties should submit their ideas to the PHO ISO maintained at SAM.gov (https://sam.gov/opp/53707a1538994e7d9ed8df8e5ee95ed1/view).

https://solutions.arpa-h.gov/PHO mailto:arpa-h_pho_iso@arpa-h.gov https://solutions.arpa-h.gov/PHO https://arpa-h.gov/ https://sam.gov/opp/53707a1538994e7d9ed8df8e5ee95ed1/view

ARPA-H PROACTIVE HEALTH OFFICE POTENTIAL INTEREST AREAS

Example interest areas include, but are not limited to:

Novel prevention, detection and prophylactic treatment methods for disease:

• Novel and scalable methods for early detection of disease and illness including the use of low/no cost sensing modalities.

• Prophylactic approaches to prevention of diseases and harmful disease outcomes.

• Methods for continuous and widespread sensing of health state and early disease indicators that can be deployed at population-scale.

Population-level approaches to increase the adoption of prevention and wellness behaviors :

• Early indicators of disease and pre-disease states and measures associated with proactive health outcomes that are both inexpensive and effective.

• Low-cost, high-uptake mental health resiliency and mindfulness building methods for individuals.

• Methods to inform and educate individuals about healthy behaviors including lifestyle and preventative medical measures.

• Methods that incentivize individuals to adopt and maintain healthy behaviors.

• Novel approaches to increasing individual healthspan and independence even in the absence of disease.

System innovation for the delivery of proactive health outcomes:

• Novel, robust and predictive surrogates for long-term health outcomes with associated epidemiological models.

• Valuation models for long-term treatment effects for vaccination, screening and other public health interventions.

• New funding and delivery models for preventative interventions.

REGISTRATION INFORMATION

Participants must register in advance through the registration website (https://solutions.arpa-h.gov/PHO). The deadline to register for the virtual Proposers’ Day is no later than 5PM ET on Friday, April 5th. Attendees will receive an email with the webinar link after registering.

The event is only open to registered potential proposers and is closed to the general public and media.

EVENT FORMAT

The virtual Proposers’ Day will include presentations by ARPA-H, including technical presentations covering the PHO strategy as well as an informational session during which the Mission Office Director and an Agreements Officer will respond to questions that are submitted in advance. A tentative agenda follows.

https://solutions.arpa-h.gov/PHO

AGENDA

2:00-2:30 PM ET: Introductions and PHO Office overview

2:30-3:00 PM ET: Questions & Answers (Q&A) session

ADMINISTRATIVE

All administrative and technical questions regarding the ARPA-H PHO ISO Virtual

Proposers’ Day event should be submitted via https://solutions.arpa-h.gov/PHO.

This special notice is issued solely for information and potential new project planning purposes; the notice does not constitute a formal solicitation for proposals nor solution summaries (abstracts). Any proposals or solution summaries received in response to this notice will be discarded.

Attendance is voluntary and is not required to submit a proposal to subsequent ARPA-H

PHO solicitations (if any). ARPA-H will not reimburse costs incurred in responding to this

Special Notice. Respondents are advised that ARPA-H is under no obligation to acknowledge receipt of any information received or provide feedback to respondents with respect to any information submitted under this Special Notice.