A02-PWS Artificial Intelligence for IDT.pdf

JUN 24

Performance Work Statement (PWS) (Includes associated Performance Requirements Summary (PRS))

PERFORMANCE WORK STATEMENT (PWS)

Artificial Intelligence (AI) for Infectious Disease Threats Indefinite Delivery Indefinite Quantity

(IDIQ)

for Walter Reed Army Institute of Research (WRAIR), Experimental Therapeutics (ET) Branch

02 August 2024

Part 1 General Information

1. General: This is a non-personal service(s) contract under which the personnel rendering the service(s) are not subject, either by the contract’s terms or by the manner of its administration, to the supervision and control usually prevailing in relationships between the Government and its employees.

1.1 Description of Services/Introduction: This is a non-personal service(s) contract to provide Artificial Intelligence (AI)/Machine-Learning (MI) services for known targets for various infectious disease threats.

1.2 Background: The Walter Reed Army Institute of Research (WRAIR) provides unique research capabilities and innovative medical solutions to a range of Force Health Protection and Readiness challenges currently facing United States (U.S.) Service Members, along with threats anticipated during future operations.

Through both times of peace and war, infectious diseases have killed, sickened, and disabled far more Service Members than bombs and bullets. WRAIR has created a model of vaccine and therapeutic development that is unique, nimble, and responsive to dynamically evolving infectious disease threats of military importance. WRAIR, with its unparalleled expertise, facilities, and international network, has developed many vaccines and drugs in use today by military and civilian medicine around the globe.

The Experimental Therapeutics (ET) Branch is a drug discovery and development enterprise created to protect military personnel from death, disease, and injury and meet Department of Defense (DoD) mission requirements. While its historical focus has been radioprotection and parasitic disease, ET applies its core competencies of medicinal, synthetic, and analytical chemistry as well as clinical pharmacology to all therapeutic areas within the Medical Research and Development Command's (MRDC’s) portfolio.

ET has a 75-year legacy of excellence in small molecule drug development, with over 65 Investigational New Drug (IND) applications submitted to the U.S. Food and Drug Administration (FDA). ET is a world leader in malaria drug development—every malaria prophylaxis drug was either created by ET scientists or transited ET test systems on its way to FDA approval. In the last decade, ET established a robust antibacterial product development effort in response to the Presidential Initiative to Combat Antibiotic Resistant Bacteria (CARB).

Within the last four years, ET pivoted toward the antiviral space in response to the COVID-19 pandemic as well as other Army Requirements such as filoviruses, flaviviruses, and other emerging threats.

1.3 Scope/Period of Performance:

1.3.1 Scope: The Contractor shall provide non-personal service(s). This shall include providing all personnel, equipment, supplies, facilities, tools, materials, supervision, and other items necessary to perform services as described in the Performance Work Statement (PWS) and associated contract documents, except for those items specified in Part 3 Government Property (GP) and Services. The Contractor shall perform to the standards and Acceptable Quality Levels (AQLs) identified in this PWS and associated contract documents.

1.3.2 Period of Performance:

The period of performance for this requirement shall be 01 February 2025 – 31 January 2026.

1.4 Objectives: The objective of this contract is to establish a Task Order (TO) contract off of an Indefinite Delivery Indefinite Quantity (IDIQ) contract for AI/ML in silico screening of candidate drug compounds against known targets for infectious disease threats of interest.

The contractor will screen multimillions of approved and novel compounds against multiple targets to be identified by the Government to identify and develop drug-like ligands. The contractor will utilize ML decision tree algorithms for potent compound identification followed by evaluation of potential toxicity, off-target effects and potential structure based metabolic liabilities. Once these hits are predicted, ET chemists will synthesize them for validation in cellular assays.

1.5 General Information:

1.5.1 Quality Control Plan (QCP):

The Contractor’s existing quality assurance system shall be utilized In Accordance With (IAW) Federal Acquisition Regulation (FAR) 12.208 (A.001).

1.5.1.1 Analysis of quality control and timeliness of submittals (i.e., deliverables) shall be provided to the Contracting Officer’s Representative (COR) within 30 days upon completion of each option period or TO (A.002).

1.5.1.2 The Contractor shall inform the COR of issues or potential issues that might affect the performance within 48 hours of identifying those issues. Verbal reports shall be followed up by written reports within two days (A.003).

1.5.2 Quality Assurance: The Government will evaluate the Contractor’s performance under this contract IAW the Quality Assurance Surveillance Plan (QASP). This plan is primarily focused on what the Government must do to ensure that the Contractor has performed IAW the performance standards. It defines how the performance standards will be applied, the frequency of surveillance, and the AQLs (performance thresholds).

1.5.3 Recognized Holidays: The following provides information on recognized holidays for the purpose of the PWS. If submittal of any documentation (e.g., deliverables, submittals, etc.) deadlines fall on a holiday, the closest work day prior to the holiday will apply as the deadline for submittal.

1.5.3.1 U.S. Holidays: Work shall not be performed on U.S. federally recognized holidays occurring during the normal workweek unless otherwise directed by the Contracting Officer (KO). When a U.S. holiday occurs on a Saturday or a Sunday, the holiday is observed on the preceding Friday or following Monday, respectively.

New Year’s Day January 1st M. L. King Memorial Day 3rd Monday in Jan Presidents’ Day 3rd Monday in February Memorial Day last Monday in May Juneteenth June 19th Independence Day July 4th Labor Day 1st Monday in September Columbus Day 2nd Monday in October Veteran’s Day November 11th Thanksgiving Day 4th Thursday in November Christmas Day December 25th

1.5.3.2 Host Nation Holidays: Reserved.

1.5.4 Operating Hours: The Government facility office hours, facility operating hours, and the Contractor support hour requirements often coincide, however, they may differ. Please refer to the following.

1.5.4.1 Government Facility Office Hours: The Government facility office hours occur between the hours of 0845 and 1430 EST, Monday through Friday, except U.S. Holidays identified in paragraph 1.5.3.1 above or when the Government facility is closed due to local or national emergencies, administrative closings, or similar Government directed facility closings.

1.5.4.2 Government Facility Operating Hours: Reserved.

1.5.4.3 Contractor Support Hours: The Contractor shall provide support during the same hours as the supported Government organization. The Contractor shall maintain an adequate workforce at all times, for the uninterrupted performance of all tasks defined within this PWS when the Government facility is not closed for the above reasons. When hiring personnel, the Contractor shall keep in mind that the stability and continuity of the workforce is essential. For other than firm fixed price contracts, the Contractor will not be reimbursed when the Government facility is closed for the above reasons.

1.5.4.3.1 Contractor Work Plan: The Contractor shall prepare and maintain a work plan.

The plan, as a minimum, shall identify regularly scheduled work (to include location, work to be completed, timeline, etc.). The Contractor’s proposed work plan shall be submitted to the KO via the COR for review within 10 days after date of contract award. The Government will review and either accept or return their comments to the Contractor within 10 days. The Contractor shall then have three days to submit a final work plan. Any proposed change to the accepted final work plan is required to be resubmitted via the COR for review and acceptance by the KO at a minimum 30 days prior to implementation. The timeline noted above shall apply for review and acceptance for proposed changes (A.004).

1.5.5 Training Holidays: Reserved.

1.6 Place of Performance: The work to be performed under this contract will be performed at the Contractor’s facilities.

1.7 Security Requirements: The following information is provided on security related matters.

1.7.1 Security Program: Reserved.

1.7.2 Personnel Security Clearance Requirements: Reserved.

1.7.3 Installation Access: Reserved.

1.7.3.1 Installation Pass Log: Reserved.

1.7.3.2 Individual Termination or Expiration of Employment: Reserved.

1.7.3.3 Contract Termination or Cancellation: Reserved.

1.7.3.4 Common Access Cards and Common Access Cards Log: Reserved.

1.7.4 Background Checks: Reserved.

1.7.5 Physical Security: The Contractor shall safeguard all Government equipment, information, and property provided for Contractor use. At the close of each work period, Government facilities, equipment, and materials shall be secured IAW the Army Physical Security Program, Army Regulation (AR) 190-13.

1.7.6 Operations Security Requirements: Reserved.

1.7.7 Key Control: Reserved.

1.8 Post Award Conference/Periodic Progress Meetings: The Contractor shall attend any post award conference convened by the contracting activity or contract administration office IAW FAR Subpart 42.5. The KO, COR, and other Government personnel, as appropriate, may meet periodically with the Contractor to review the Contractor's performance.

At these meetings the KO will apprise the Contractor of how the Government views the Contractor's performance and the Contractor shall apprise the Government of problems, if any, being experienced. Appropriate action shall be taken to resolve outstanding issues. These meetings shall be at no additional cost to the Government.

The Contractor shall attend, participate in, and furnish input to scheduled and unscheduled meetings, conferences, and briefings that relate to the functions and services herein as required by the Government to provide effective communication and impart necessary information. The Contract Manager or designated representative shall attend meetings as requested by the Government. Meeting attendees shall at times include Contractor managerial, supervisory, and other personnel knowledgeable of the subject matter. Meetings may start or end outside of regular duty hours.

1.9 Contracting Officer’s Representative (COR): Refer to Part 2 of this PWS for the definition of a COR. As determined by the KO, a COR will be appointed and identified by letter of designation, a copy of which will be provided to the Contractor by the KO. The designation letter states the responsibilities and limitations of the COR, especially with regard to changes in cost or price, estimates, or changes in delivery dates. The COR is not authorized to change any of the terms and conditions of the resulting order. The COR monitors all technical aspects of the contract and assists in contract administration. The COR is not authorized to obligate the Government. If the work is not written in the contract, the COR is not authorized to request new work. The COR is authorized to perform the following functions: assure that the Contractor performs the technical requirements of the contract, perform inspections necessary in connection with contract performance, maintain written and oral communications with the Contractor concerning technical aspects of the contract, issue written interpretations of technical requirements, including Government drawings, designs, specifications, monitor Contractor's performance and notifies both the KO and Contractor of any deficiencies, coordinate availability of GP, and coordinate site entry of Contractor personnel.

1.10 Key Personnel: Reserved.

1.11 Identification of Contractor Employees: Reserved.

1.12 Contractor Travel: Reserved.

1.13 Other Direct Costs (ODCs): Cost type Contract Line Item Numbers (CLINs) under this contract will be invoiced as Other Direct Costs (ODCs). The Contractor shall manage and account for all costs associated with requirements labeled as ODCs, not to exceed the price ceiling listed in this contract.

1.13.1 Invoices: The contractor shall submit invoices monthly to Wide Area Work Flow (WAWF) with sufficient documentation to provide certification of invoice.

The contractor is responsible for properly preparing and forwarding to the appropriate Government official, the invoice and receiving report for payment. The contractor shall attach back up information to receiving reports for ODCs.

Backup information for ODCs shall list all elements of costs. All ODCs exceeding $3,000 requires the contractor to conduct appropriate competition and obtain approval from the COR prior to purchase. Equipment purchases are not authorized under this contract. The Wide Area Workflow – Receipt and Acceptance application is the required method of submission.

Where applicable, contractor will include additional ODC invoice details as required per protocol for any volunteer payments in support of this PWS.

1.14 Data Rights: The Government has unlimited rights to all documents and materials produced under this contract. All documents and materials, to include the source codes of software, produced under this contract shall be Government owned and are the property of the Government with all rights and privileges of ownership and copyright belonging exclusively to the Government. These documents and materials may not be used or sold by the Contractor without written permission from the KO. All materials supplied to the Government shall be the sole property of the Government and may not be used for any other purpose. This right does not abrogate any other Government rights.

1.15 Non-Disclosure Requirements: Performance under this contract may require the Contractor to access data and information proprietary to a Government agency, another Government Contractor, or of such nature that its dissemination or use other than as specified in this work statement would be adverse to the interests of the Government or others. The Contractor and Contractor personnel, shall not divulge or release data or information developed, or obtained under performance of this PWS, except to authorized Government personnel or upon written approval of the KO. The Contractor shall not use, disclose, or reproduce proprietary data, which bears a restrictive legend, other than as specified in this PWS. All documentation showing individual names or other personal information shall be controlled and protected under the provisions of the Privacy Act of 1974, Public Law 93-579, 5 United States Code (U.S.C.) Section 552a.

1.15.1 Non-Disclosure Statements: The Contractor shall provide signed non-disclosure agreements to the Government no later than 30 days prior to commencement of work under the contract. Disclosure of information by Contractor personnel may result in removal of Contractor personnel from performance under this contract (A.005).

1.16 Protection of Government and Contract Information: Per Public Use Notice of Limitations stated by Defense Imagery Management Operations Center and contained at www.dimoc.mil/resources/limitations/, the Contractor shall not cite any information (e.g., contract information, pictures, locations, etc.) obtained through this contract on any hard copy or digital marketing tools to include its company website.

1.17 Organizational Conflict of Interest (OCI): Contractor and subcontractor personnel performing work under this contract may receive, have access to or participate in the http://www.dimoc.mil/resources/limitations/ development of proprietary or source selection information (e.g., cost or pricing information, budget information or analyses, specifications or work statements, etc.) or perform evaluation services which may create a current or subsequent Organizational Conflict of Interest (OCI) as defined in FAR Subpart 9.5. The Contractor shall notify the KO immediately whenever it becomes aware that such access or participation may result in any actual or potential OCI and shall promptly submit a plan to the KO to avoid or mitigate any such OCI. The Contractor’s OCI mitigation plan will be determined to be acceptable solely at the discretion of the KO. In the event the KO unilaterally determines that any such OCI cannot be satisfactorily avoided or mitigated, the KO may affect other remedies as he or she deems necessary, including prohibiting the Contractor from participation in subsequent contracted requirements which may be affected by the OCI (A.006).

1.18 Phase In /Phase Out Period: Reserved.

1.19 Safety: Reserved.

1.20 Environmental Compliance: Reserved.

1.21 Required Training: Reserved.

1.22 Authorization to Perform Services in Foreign Countries: Reserved.

1.23 Notice to Proceed: Reserved.

1.24 Electromagnetic Compatibility Directive: Reserved.

1.25 Government Property (GP) and Services: Reserved.

1.26 Conventional Forces Europe (CFE) Treaty Verification Inspection: Reserved.

PART 2

DEFINITIONS & ACRONYMS

2. Definitions and Acronyms

2.1 Definitions: Although not inclusive of every term used within this PWS, the following provides a list of definitions used throughout this PWS and commonly used in the acquisition field.

Contracting Officer – means a person with the authority to enter into, administer, and/or terminate contracts and make related determinations and findings on behalf of the Government. Note: The only individual who can legally bind the Government.

Contracting Officer's Representative (COR) – As defined in Defense Federal Acquisition Regulation Supplement (DFARS) 202.101, means an individual designated and authorized in writing by the KO to perform specific technical or administrative functions. DoD Instruction (DoDI) 5000.72, Part II Definitions states the following when defining a COR: “Defined in subpart 202.101 of Reference (f). Any individual delegated responsibilities pursuant to subpart 1.602-2 of Reference (e), regardless of local terminology, must be certified IAW this instruction. For example, local terminology can be COR, KO’s technical representative, technical point of contact, technical representative, alternate COR, administrative COR, assistant COR, line-item manager, task order manager, quality assurance personnel, quality assurance evaluator, or COR management.” In addition, AR 70-13, Chapter 2, paragraph 2-2g, states, in part, the following when providing other surveillance support personnel to assist the COR when needed, “…These other surveillance support personnel may serve as on-site representatives of the COR in performance of actual contract surveillance if they meet all COR requirements and have been appointed by the KO as alternate CORs.”

Contractor – means a supplier or vendor awarded a contract to provide specific supplies or service to the Government. The term used in this contract refers to the prime.

Contractor-acquired Property - means property acquired, fabricated, or otherwise provided by the Contractor for performing a contract and to which the Government has title.

Day – means, unless otherwise specified, a calendar day.

Defective Service – means a service output that does not meet the standard of performance associated with the PWS.

Deliverable – means anything that can be physically delivered, but may include non-manufactured things such as meeting minutes or reports.

Government-Furnished Property – As reflected in FAR 52.245-1, Government-furnished Property “means property in the possession of, or directly acquired by, the Government and subsequently furnished to the Contractor for performance of a contract. Government-furnished property includes, but is not limited to, spares and property furnished for repair, maintenance, overhaul, or modification. Government-furnished property also includes contractor-acquired property if the contractor-acquired property is a deliverable under a cost contract when accepted by the Government for continued use under the contract.

Government Property (GP) - means all property owned or leased by the Government. GP includes both Government-furnished and Contractor-acquired property. GP includes material, equipment, special tooling, special test equipment, and real property. GP does not include intellectual property and software.

Property Administrator - means an authorized representative of the KO appointed IAW agency procedures, responsible for administering the contract requirements and obligations relating to GP in the possession of a Contractor.

High Level Objective (HLO) – means a key overarching result-based objective for a project necessary to achieve the project’s vision. HLOs are similar to Level 2 in a Work Breakdown Structure. Each HLO may contain several statements to flesh out the areas necessary to meet the objective.

Physical Security – means that part of security concerned with physical measures designed to safeguard personnel; to prevent unauthorized access to equipment, installations, material, and documents; and to safeguard against espionage, sabotage, damage, and theft.

Quality Assurance – (or Government contract quality assurance) means the various functions, including, inspection, performed by the Government to determine whether a Contractor has fulfilled the contract obligations pertaining to quality and quantity.

Quality Assurance Surveillance Plan (QASP) – means the key Government-developed surveillance process document, and is applied to Performance-Based Service Contracting (PBSC). The QASP is used for managing Contractor performance assessment by ensuring that systematic quality assurance methods validate that Contractor quality control efforts are timely, effective, and are delivering the results specified in the contract or TO. The QASP directly corresponds to the performance objectives and standards (i.e., quality, quantity, timeliness) specified in the PWS. It provides specific details on how the Government will survey, observe, test, sample, evaluate, and document Contractor performance results to determine if the Contractor has met the required standards for each objective in the PWS. The QASP, with very few if any exceptions, is an internal to Government document.

Quality Control – means all necessary measures taken by the Contractor to assure that the quality of an end product or service shall meet contract requirements.

Statement – means the specific results-based activities required to satisfy HLOs. A statement contains a result, the context of the statement, and the required action(s). Statements focus on “what” is to be accomplished; however, they are not prescriptive in describing “how” the outcome is to be achieved. Each HLO may have several statements to flesh out the areas necessary to meet the objective. Statements are similar to Level 3 in a Work Breakdown Structure.

Subcontractor – means one that enters into a contract with a prime Contractor. The Government does not have privity of contract with the subcontractor.

Work Day - The number of hours per day the Contractor provides services IAW the contract.

Work Week - Monday through Friday, unless otherwise specified.

2.2 Acronyms: Although not inclusive of every term used within this PWS, or that may be included in an acquisition, the following provides a list of acronyms commonly used in the acquisition field.

AI Artificial Intelligence ANN Artificial Neural Network AQL Acceptable Quality Level AR Army Regulation CARB Combat Antibiotic Resistant Bacteria CLIN Contract Line Item Number COR Contracting Officer’s Representative DFARS Defense Federal Acquisition Regulation Supplement DoD Department of Defense DoDI Department of Defense Instruction ET Experimental Therapeutics FAR Federal Acquisition Regulation FDA Food and Drug Administration FTE Full Time Employee FY Fiscal Year GP Government Property HLO High Level Objective IAW In Accordance With IDIQ Indefinite Delivery Indefinite Quantity IND Investigational New Drug KO Contracting Officer ML Machine-Learning MRDC Medical Research and Development Command MS Microsoft OCI Organizational Conflict of Interest ODC Other Direct Cost PBSC Performance-Based Service Contracting PDF Portable Document Format PRS Performance Requirements Summary PWS Performance Work Statement QASP Quality Assurance Surveillance Plan QCP Quality Control Plan SAM System for Award Management SCR Service Contract Report

TO Task Order U.S. United States U.S.C. United States Code WAWF Wide Area Work Flow WRAIR Walter Reed Army Institute of Research

PART 3

GOVERNMENT PROPERTY (GP) AND SERVICES

3. Government Property (GP) and Services

3.1 Services: Reserved.

3.2 Facilities: Reserved.

3.3 Utilities: Reserved.

3.4 Equipment: Reserved.

3.5 Special Tooling and Test Equipment: Reserved.

3.6 Materials: Reserved.

3.7 Training: Reserved.

3.8 Common Access Cards: Reserved.

PART 4

CONTRACTOR FURNISHED ITEMS AND SERVICES

4. Contractor Furnished Property and Services

4.1 General: Reserved.

4.2 Secret Facility Clearance: Reserved.

4.3 Materials: Reserved

4.4 Vehicles and Equipment: Reserved.

4.5 Background Checks: Reserved.

PART 5

SPECIFIC TASKS

5.1 Basic Services: The Contractor shall provide services by screening multimillions of approved and novel compounds against multiple targets to be identified by the Government to identify and develop drug-like ligands. The Contractor shall utilize ML decision tree algorithms for potent compound identification followed by evaluation of potential toxicity, off-target effects and potential structure based metabolic liabilities. Once these hits are predicted, ET chemists will synthesize them for validation in cellular assays.

5.2 Tasks: Tasks consist of the following:

5.2.1 The Contractor shall train the Artificial Neural Network (ANN) using known pathogen-specified inhibitor and targets identified in literature.

5.2.1.1 The Contractor shall identify, evaluate, and select pathogen-specified protein crystal structures.

5.2.1.2 The Contractor shall create 3D models of inhibitor candidates and dock into pathogen-specified protein targets.

5.2.2 The Contractor shall perform a supercomputer-based virtual screen for new pathogen-specified small molecule scaffolds, based on the ML algorithm.

5.2.2.1 The Contractor shall port the ANN system to a high-performance supercomputer or performer’s local computing facility.

5.2.2.2 The Contractor shall screen a specified number of candidates from commercial libraries with ANN for predicted pathogen-specified inhibition and rank.

5.2.2.3 The Contractor shall provide a hit-list of potential inhibitor compounds for procurement and testing by WRAIR in an assessment report. The draft report will be due 10 days after experiment completion, and the final version will be due within 3 days of receipt of Government comments on draft (A.007).

5.2.3 The Contractor shall submit monthly progress reports once per month every month for the duration of a TO describing the progress made during the month and the current status of the project (A.008).

5.3 Service Contract Reporting

5.3.1 System for Award Management (SAM) Service Contract Report (SCR): The Contractor shall report ALL Contractor labor hours (including subcontractor labor hours) required for performance of services provided under this contract for the WRAIR via a secure data collection site. The Contractor is required to completely fill in all required data fields through the following web address: www.sam.gov. Reporting inputs will be for the labor executed during the period of performance during each Government Fiscal Year (FY), which runs from October 1 through September 30. While inputs may be reported any time during the FY, all data shall be reported no later than October 31 of each calendar year. Contractors may direct questions to the help desk by clicking “View Assistance for SAM.gov” which is located at the top of the SAM.gov website. From there, you can the select “Contact Our Service Desk” which will allow you to contact SAM.gov directly. If contract period of performance ends prior to September 30, the Contractor has 30 calendar days from end date of the contract to complete the SAM SCR requirement (A.009).

Steps for Submitting a Service Contract Report (SCR)

1. Go to www.sam.gov and log in.

2. Select Entity Registrations and then select SCR.

3. SAM displays your entities which have service contracts and meet the reporting criteria.

Select View by entity to see the service contracts for each entity.

4. Next, select Add for the service contract against which you want to create a SCR. Each service contract which meets the FAR Subpart 4.1703 reporting thresholds is displayed.

5. You will be taken to the Complete SCR page. SAM displays the contract details and allows you to report. You are required to enter the following information:

• Total Amount Invoiced: Total dollar amount invoiced for services performed during the previous Government FY under the contract (this amount should include the prime and any subcontract amount).

• Prime Contractor Hours Expended: Prime contractor direct labor hours expended on the services performed during the previous Government FY. The amount you enter is automatically divided by 2,080 hours to calculate a Full Time Employee (FTE) equivalent, displayed under the Prime Contractor Hours Expended as Prime Contractor FTEs.

6. Report any required Tier 1 subcontractor information by selecting the Add Tier 1 Subcontract Information button.

7. When you are ready to submit the report, select Submit. This saves your report and returns you to the Select Service Contract page where you can create other SCRs or edit an existing SCR.

Steps for Editing a Submitted Report

1. Follow steps 1-4 above. Any previously submitted SCR will have a View/Edit button instead of an Add button.

2. Select View/Edit. You will be able to view the current SCR, edit available fields, and resubmit the record. You can also delete previously entered information altogether.

STD: All information provided by the Contractor shall be accurate, complete, and not exceed suspense dates noted in corresponding paragraph above.

AQL: 100% Compliant http://www.sam.gov/

PART 6

APPLICABLE PUBLICATIONS

6. Applicable Publications (Current Editions): The following publications, manuals, regulations, etc. are mentioned in this PWS and are listed below.

6.1.1 Defense Federal Acquisition Regulation Supplement (DFARS) 202.101

6.1.2 DoD Instruction (DoDI) 5000.72

6.1.3 AR 70-13, Chapter 2, paragraph 2-2g

6.1.4 Privacy Act of 1974

6.1.5 Public Law 93-579

6.1.6 5 United States Code (U.S.C.) Section 552a

PART 7

ATTACHMENT AND TECHNICAL EXHIBIT LISTING

7. Attachment and Technical Exhibit List

7.1 Technical Exhibit A – PRS

7.2 Technical Exhibit B – Deliverables Schedule

TECHNICAL EXHIBIT A

Performance Requirements Summary (PRS)

PERFORMANCE

OBJECTIVE

STANDARD PERFORMANCE

THRESHOLD

ACCEPTABLE

QUALITY LEVELS

(AQLs)

METHOD

OF

SURVEILL

ANCE

PRS#1 –

Identification, evaluation, and selection of protein crystal structures -

PWS # 5.2.1.1

The Contractor shall identify, evaluate, and select pathogen-specified protein crystal structures.

No avoidable delays of more than 1 week

100% inspection

Frequency:

Monthly Progress Reports

PRS#2 – Candidate docking into protein targets -

PWS #5.2.1.2

The Contractor shall create 3D models of inhibitor candidates and dock into pathogen-specified protein targets.

95% of experiments shall be satisfactorily completed.

Experiments completed unsatisfactorily shall be reworked.

100% inspection

Frequency:

Monthly Progress Reports

PRS#3 – ANN

porting - PWS 5.2.2.1

The Contractor shall port the ANN system to a high-performance supercomputer or performer’s local computing facility.

No avoidable delays of more than 1 week

100% inspection

Frequency:

Monthly Progress Reports

PRS#4 – Candidate screening - PWS 5.2.2.2

The Contractor shall screen a specified number of candidates from commercial libraries with ANN for predicted pathogen-specified inhibition and rank.

95% of experiments shall be satisfactorily completed.

Experiments completed unsatisfactorily shall be reworked.

100% inspection

Frequency:

Monthly Progress Reports

PRS #5 – SCR-

PWS 5.3

The Contractor shall completely fill in all the information in the format using the following web address www.sam.gov The contractor shall provide the estimated total cost (if any) incurred to comply with this reporting requirement.

Zero deviation from Standard

100% Inspection

Reporting period shall be the period of performance not to exceed 12 months ending September 30 of each government FY and must be reported by 31 October of each calendar year. If contract period of performance ends prior to September 30, the contractor has 30 days from end date of the contract to complete the SCR requirement.

TECHNICAL EXHIBIT B

DELIVERABLES SCHEDULE

Deliverable Frequency # of Copies Medium/Format Submit To A.001

Quality Control Plan (QCP)

(Para 1.5.1)

Draft QCP due within 10 days of award;

final QCP due within 30 days of receipt of Government comments

Proposed changes due NLT 30 days prior to anticipated change and implementation

1 Electronic document (Microsoft (MS) Word, MS Excel, or Portable Document Format (PDF))

COR

A.002

Analysis of Quality Control and Timeliness of Submittals

(Para 1.5.1.1)

Due within 30 days upon completion of each option period or Task Order

1 Electronic document (MS Word, MS Excel, or PDF)

COR

A.003

Performance Issues or Potential Issues Report

(Para 1.5.1.2)

Verbal report due within 48 hours of identifying potential issues; written report due within 2 days thereafter

1 Electronic document (MS Word, MS Excel, or PDF)

COR

A.004

Contractor Work Plan

(Para 1.5.4.3.1)

Draft due within 10 days after contract award; final work plan due within 3 days of receipt of Government comments on draft

Proposed changes thereafter due 30 days prior to implementation of proposed changes

1 Electronic document (MS Word, Excel, or

PDF)

COR

A.005

Non-Disclosure Agreements

(Para 1.15.1)

30 days before commencement of work under the contract

1 Electronic document (MS Word, MS Excel, or PDF)

COR

A.006

Due immediately when Contractor

1 Electronic document (MS

COR

Deliverable Frequency # of Copies Medium/Format Submit To OCI Mitigation Plan

(Para 1.19) becomes aware that such access or participation may result in an actual or potential OCI

Word, Excel, or

PDF)

A.007

Assessment Report

(Para 5.2.2.3)

Draft due within 10 days after experiment completion. Final version due within three days of receipt of Government comments on draft.

1 Electronic document (MS Word, Excel, or

PDF)

COR

A.008

Monthly Progress Report

(Para 5.2.3)

Due once per month every month for the duration of the task order

1 Electronic document (MS Word, Excel, or

PDF)

COR

A.009

SCR

(Para 5.3)

NLT 31 October each calendar year and within 30 calendar days from the end date of the contract

1 Electronic document (MS Word or Excel &

PDF)

www.sam.gov