Attachment 1 - Purchase Description.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) Neuroscience Unit requires a focused ultrasound system to conduct brain imaging in awake, freely-moving rodents in various behavioral conditions.

2. Background Information and Objective:

The NIDA IRP Mission is to conduct state-of-the-art basic, preclinical and clinical research on mechanisms that underlie substance use disorder, addiction and relapse.

Ultimately, we hope to translate these efforts into new methods for the prevention and treatment of substance use disorder highlighting the following: enhancing our research by taking advantage of our unique and outstanding strengths; increasing translational research and fortifying our clinical portfolio; strengthening our basic science with investment in technology; increasing Diversity and Inclusion at all levels; and prioritizing Trans-NIH initiatives and growing strong ties with other institutes.

NIDA conducts state-of-the-art neuropsychopharmacology research using preclinical models of drug addiction with translational relevance. NIDA has conducted brain imaging in anesthetized rodents with functional magnetic resonance imaging. NIDA now requires brain images in awake, freely-moving rodents. This approach will provide an unprecedented way of investigating whole-brain circuitries while rodents are engaging in drug-related behaviors. NIDA intends to test the effects of compounds that reduce drug seeking and taking while examining brain-wide activity. NIDA require a brand name or equal focused ultrasound system that is compatible with our recently procured PhenoSys JetBall Virtual Reality System. NIDA requires a focused ultrasound system that comes with devices and software for focused ultrasound brain imaging. NIDA also requires focused ultrasound to interfere with drug and brain interactions.

3. Name of Product: Focused Ultrasound System

4. Purchase Description: NIDA requires the following brand name or equal items and salient characteristics:

a. VANTAGE NXT 256 – MID FREQUENCY CONFIGURATION: PART NO.

K00006. Qty. 1

• Acquisition System - 256 Transmit channels / 256 Receive channels

• Optical PCI Express Cable

• Performance Host Controller - includes installation of PCI express adapter card. Installation of firmware and drivers; custom configuration of BIOS;

loading of VERASONICS software including HAL, VSX, example scripts and licenses; thorough testing of the entire configuration

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

• Image Reconstruction

• Synchronization Triggers

• One-year hardware manufacturing defect warranty starting from the delivery date– As set forth in the Master Agreement

b. Vantage NXT UTA 260-D: PART NO. P03167. Qty. 1

• Dual 260 pin transducer connector

c. Upgrade Vantage NXT 256 to HIFU Configuration: Qty. 1

Includes External HIFU power supply

d. Vantage NXT Extended Transmit Software License: PART NO. P03242. Qty. 1

e. L22-14vX Linear Array Transducer: PART NO. P01937. Qty. 1

Salient characteristics

Must be compatible with mice and rats Must perform real-time brain imaging Must provide focused ultrasound software Must allow customization for focused ultrasound settings

5. Delivery Date: Desired shall be made 12-16 weeks After Receipt of Order (ARO).

Delivery shall be made to:

Leandro Vendruscolo National Institutes of Health 251 Bayview Blvd.

BRC Room 08A723 Baltimore, Maryland 21224 United States