B. SOW_CellMosaic.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

STATEMENT OF WORK (SOW)

GENERAL INFORMATION

Title of Project:

Synthesis of ‘961 for National Center for Advancing Translational Sciences (NCATS), Early Translation

Branch (ETB)

Statement of Need and Purpose:

NCATS is in need of a large quantity of the less active enantiomer (‘961) of lead NNMT inhibitor ‘960 for animal studies.

Background Information and Objective:

The National Institutes of Health (NIH) is the nation’s leading medical research agency and the primary

Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people’s health and save lives.

The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of

Health (NIH), whose mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

The Early Translation Branch aims to uncover new small-molecule probes for disease targets and advance the process of therapeutic development through a collaborative research model. Its teams have expertise in assay biology, high-throughput screening, medicinal chemistry, cheminformatics and data science to complement the disease-area expertise of external collaborators.

The lead inhibitor ‘960 from the NNMT program is being evaluated in multiple efficacy, pharmaceutics and toxicity studies with a constant need for more materials. This contract will help synthesize 100 g of

‘961, the less active enantiomer of ‘960, for use as a control in all studies.

Period of Performance:

12 months ARO.

SCOPE OF WORK

General Requirements:

Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the

Government as needed to perform the Statement of Work below:

Specific Requirements:

- Delivery of 100 g of ‘961 with QC indicating >99% purity.

- 100 g of final product by weight and supplied in one bottle.

LEVEL OF EFFORT:

Scientist and/or technician with experience in compound synthesis.

GOVERNMENT RESPONSIBILITIES

NCATS will share existing protocols for the synthesis that has been executed in 4-5 g scale.

DELIVERY OR DELIVERABLES

Delivery of 100 g of ‘961 with QC indicating >99% purity.

REPORTING REQUIREMENTS

periodic progress reports in monthly and ad hoc meetings and email.

OTHER CONSIDERATIONS

Travel:

N/A

Key Personnel:

Information System Security Plan:

Data Rights:

FAR 52.227-17, Rights in Data- Special Works

Section 508—Electronic and Information Technology Standards:

Publications and Publicity:

Contractor shall not publish any information without informing NCATS. All information is confidential and NCATS will solely determine date for publication or publicity or patenting.

Confidentiality of Information:

All information shared between NCATS and contractor is confidential. The time or method for publication will be determined by NCATS.