D_24_003081_Purchase_Description 6.24.24.pdf

Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

PURCHASE DESCRIPTION

1. Statement of Need and Purpose:

The National of Mental Health (NIMH) Section on Behaviorial Neuroscince (SBN) requires the acquisition of a wireless fiberphotometry.

Current approaches into investifgations of brain circuits and systems require detailed analyses of neuronal circuit dynamics in freely moving animals with neurotransmitter specificity. Wireless approaches to data recording allow animals freedom of movement and are easier to combine with other testing equipment. Projects being pursued by multiple members of the Section on Behavioral Neuroscience (SBN) require the acquisition of a ready to use (turnkey) wireless fiber photometry (FP) system. Fiber photometry allows measuring of neural activity via Calcium and neurotransmitter-specific sensors. There are two wired FP systems already in use at SBN and two more wireless

FP systems will complement the existing FP systems as well as expand SBN’s members ability of recording neuronal activity in a larger set of behavioral tests. Wireless

FP system is especially suitable for work with non-human primates.

2. Background Information and Objective: Fiber photometry is a neuronal imaging technique used to monitor neuronal activity of specifically targeted cell populations. Fiber photometry uses excitation light from implanted fiber optics to record fluorescent activity of genetically encoded Calcium or neurotransmitter-specific indicators in neuronal populations that fluoresce in the presence of Calcium ions or neurotransmitter molecules. This imagining can be used at the same time that behavioral or electrophysiology experiments are being conducted giving a better understanding of the underpinning of brain function and its role in animal behavior in freely moving animals.

Due to SBN's growing integration of fiber photometry into their standard experimental paradigms and expansion into work with non-human primates, two new wireless FP systems are required. These systems will complement two existing wired FB systems, but allow neuronal data recording in experimental settings where animals are jumping and moving in the vertical direction, as non-human primates tend to do. In such conditions a wireless FP is needed to avoid large movement-related artifacts in the recorded data and to prevent damage of the FP equipment.

3. Generic Name of Product: Wireless Fiber Photometry System.

4. Purchase Description:

Wireless Fiber Photometry System:

(2) TeleFiph-set

TeleFipho Standard Set includes:

TTeleFiT 1x TeleFipho Transmitter Headstage, Version 11-30-2016-1 FAR Part 11—Describing Agency Needs

TeleFiCharger 1x TeleFipho Charger, TeleFiC-l-d 3x TeleFipho Cannula, TeleFiTool 1x Insertion Tool for TeleFipho, TeleFiDummy 1x TeleFipho Dummy Headstage (E59.100.00)

(2) TeleFiMP TeleFipho Metal Plate Antenna For stabilized, long distance transmission type,

(1) TeleFi Screw 150 Set screw for TeleFit headstage. Qty: 150(E59.01.01),

(1) Shipping and Handling S&H (111.201.91)

5. Salient characteristics

The Wireless Fiber Photometry System requires the following salient characteristics:

• Compatible with the two existing wired FB systems

• Allow neuronal data recording in experimental settings where animals are jumping and moving in the vertical direction.

• Wireless to avoid large movement-related artifacts in the recorded data and to prevent damage of the FP equipment.

• Wireless transmission, no cords that impede animal’s movement and introduce movement artifacts in the recorded signal.

• Can be used for both rats and marmosets in the lab and contains a small headstage good for mice, rats, marmosets, etc.

6. Quantity:

• Two (2) sets of each of the TeleFipho-set

• Two (2) sets of theTeleFiMP and one set of TeleFi Screww set

7. Delivery Date: The desired lead time is 3 to 4 weeks after the purchase is received.

Delivery address (Ship to):

Denis Matrov

National Institute of Mental Health (NIMH)

Building 35A, Room 2D-802

35A Convent Dr

Bethesda , MD 20892

United States of America

Phone: 301-451-9219

8. Period of Performance: N/A. Standard manfufacturer warranty with purchase

9. Option(s): N/A