RFP 75N95022R00108_Amendment 01.pdf

(x)

75N95022R00108 x x copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted ; or (c) By separate letter or electronic communication which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE

RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR

OFFER. If by virtue of this amendment you desire to change an offer already submitted , such change may be made by letter or electronic communication, provided each letter or electronic communication makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

x

NIA

Bethesda, MD 20892-7511 National Institute on Aging National Institutes of Health

NIDA-EXEC

Bethesda, MD 20892-7511 National Institute on Drug Abuse National Institutes of Health

13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

12. ACCOUNTING AND APPROPRIATION DATA (If required) is not extended.is extended, Items 8 and 15, and returning _______1____

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended , by one of the following methods: (a) By completing

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

FACILITY CODE CODE

10B. DATED (SEE ITEM 13)

10A. MODIFICATION OF CONTRACT/ORDER NO.

9B. DATED (SEE ITEM 11)

11/22/2022

9A. AMENDMENT OF SOLICITATION NO.

CODE

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

To All Potential Offerors

7. ADMINISTERED BY (If other than Item 6)CODE 6. ISSUED BY

PAGE OF PAGES

4. REQUISITION/PURCHASE REQ. NO.3. EFFECTIVE DATE

12/19/2022

2. AMENDMENT/MODIFICATION NO.

5. PROJECT NO. (If applicable)

1. CONTRACT ID CODE

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

CHECK ONE A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority) appropriation data, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

E. IMPORTANT: Contractor is not is required to sign this document and return __________________ copies to the issuing office.

ORDER NO. IN ITEM 10A.

16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

Fred Ettehadieh, Contracting Officer

15A. NAME AND TITLE OF SIGNER (Type or print)

15C. DATE SIGNED 16B. UNITED STATES OF AMERICA

Fred Ettehadieh

15B. CONTRACTOR/OFFEROR 16C. DATE SIGNED

12/19/2022 (Signature of person authorized to sign) (Signature of Contracting Officer)

STANDARD FORM 30 (REV. 11/2016)

Prescribed by GSA FAR (48 CFR) 53.243

Previous edition unusable

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

PURPOSE: Responses to Questions relevant to responding to this solicitation have been included in the continuation pages.

**SEE CONTINUATION PAGES**

ALL OTHER TERMS AND CONDITIONS OF THE SOLICITATION REMAIN UNCHANGED

Except as provided herein, all terms and conditions of the document referenced in Item 9 A or 10A, as heretofore changed, remains unchanged and in full force and effect .

RFP Number: 75N95022R00108 Page 2 of 4 Amendment No. 01

Responses to Questions relevant to responding to this solicitation have been included below.

1. Question: Would the Government consider an extension to the due date of proposals?

1. Response: See Amendment 01, which includes the new proposal due time and date: 4:00 pm local time on 1/17/2023.

2. Question: Specify all “days” that are currently not specified either be business or calendar days for the purpose of clear and mutual understanding and expectations.

2. Response: In accordance with FAR 2.101, Day means, unless otherwise specified, a calendar day.

3. Question: Per this section of the SOW, Task Area 2, the Government is requesting that the colony must be re-derived from frozen embryos. Is the government providing frozen embryos to support the contract? The offeror is already cryopreserving embryos, are we able to utilize those embryos? How many embryos are in storage, and where is the storage located other than in the contractor’s site(s)?

At what stage of development are the embryos? Has the Government conducted any invivo QC? It would be helpful for offeror to know that information to have an idea of the possible pup yield rate.

3. Response: The frozen embryos to be used for rederivation are currently being generated and cryopreserved by Charles River under a separate contract. Approximately 1400 F344 and 600 Brown Norway embryos are being cryopreserved, which should yield 100 F344 and 50 Brown Norway offspring post-rederivation.

4. Question: Proposed Task Order Number 1 SOW, Section III. Task Order Scope, Section B. states, the numbers of breeding rats to be maintained shall be at a level that permits the addition of male and female weanling rats to the aging colony at the rate required for each colony segment as described herein (Contract SOW Task Area 3):

STRAIN SEX TOTAL ENTERED

- RFP

TOTAL ENTERED -

Current

F344 Male 650 575

F344 Female 450 275

BN Male 60 60

BN Female 20 45 – Every 3rd Month

F344B

N F1

Male 365 365

F344B

N F1

Female 250 150

Clarify the total entries per month as the requested and current entries are different.

4. Response: The numbers in the solicitation are correct. They are different from the current entry levels.

5. Question: SECTION E - INSPECTION AND ACCEPTANCE; page 10. Provide the full address.

RFP Number: 75N95022R00108 Page 3 of 4 Amendment No. 01

5. Response: Full address will be specified in the resultant contract.

6. Question: Cost- reimbursement clauses on page 36. Assumption is made that at the time of award only those General Clauses applicable to the type of organization of the successful offeror will apply.

Please confirm.

6. Response: Confirmed

7. Question: ARTICLES I. 2 & 3 Authorized Substitution of Clauses:

Assumption is made that FAR 52.215-2 Alt II, and FAR 52.249-5 will not be substituted when the successful offeror is not an educational or other non-profit institution.

Request that FAR 52.216-15 be removed as it is not applicable.

Request that FAR 52.227-14 be the applicable clause, not its Alternate IV.

Assumption is made that FAR 52.230-5 will be removed when not applicable.

Request FAR 52.239-1 Privacy or Security Safeguards, be removed as the scope of work is not for information technology.

Request that the changes clause applicable shall be FAR 52.243-2 Alternate I.

7. Response: FAR 52.239-1 Privacy or Security Safeguards is removed from this solicitation. The other ones will remain since this is a full and open competition solicitation and it is unknown whether an educational or non-profit institution will receive the award.

8. Question: TYPE OF CONTRACT AND NUMBER OF AWARDS; Level of Effort, page 54. Confirm this is not an LOE type contract, and that this paragraph is for informational purposes only.

8. Response: Confirmed.

9. Question: GENERAL INSTRUCTIONS; page 55. Confirm that only electronic submittal of this proposal is required?

9. Response: Confirmed.

10. Question: Alternate I (October 2010) of FAR Clause 52.215-20, Requirements for Certified Cost or Pricing Data and Data Other than Cost or Pricing Data (October 2010). As prescribed in 15.408(l)(and see 15.403-5(b)(1)), substitute the following paragraph (b)(1) for paragraph (b)(1) of the basic provision: Confirm that Alternate IV of this clause is applicable to this program. We presume cost or pricing data is not required pursuant to FAR 15.403-1 (c) (1) with the assumption that this is a full open competition.

10. Response: Certified Cost or Pricing Data is required. Refer to the Solicitation page 72, item C. and the Solicitation page 48, Attachment 14, Certified of Current Cost or Pricing Data.

11. Question: ENHANCING REPRODUCIBILITY THROUGH RIGOR AND TRANSPARENCY; page 71.

Stated requirement: “The offeror shall demonstrate compliance with the NIH Policy on enhancing Reproducibility through Rigor and Transparency as described in NIH Guide Notice NOT- OD-15-103.

Specifically, the offeror shall describe in its technical proposal the information described below”: - There

RFP Number: 75N95022R00108 Page 4 of 4 Amendment No. 01 was no information provided that preceded the statement. Please provide the content that should have followed.

11. Response: ENHANCING REPRODUCIBILITY THROUGH RIGOR AND TRANSPARENCY language will remain as is. Copied from the solicitation page 71 “The offeror shall demonstrate compliance with the NIH Policy on enhancing Reproducibility through Rigor and Transparency as described in NIH Guide Notice

NOT- OD-15-103.”