RFP_75N94025R00007-Amendment_1_6-18-2025_FINAL_signed_0001.pdf

OMB No.: 0990-0115

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

PAGE

OF PAGES

2. AMENDMENT/MODIFICATION NO.

3. EFFECTIVE DATE

06/18/2025

4. REQUISITION/PURCHASE

REQ. NO.

5. PROJECT NO. (if applicable)

6. ISSUED BY CODE

7. ADMINISTERED BY (If other than Item 5) CODE

National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development Contracts Management Branch 6710B Rockledge Drive

BETHESDA MD 20892

8. NAME AND ADDRESS OF CONTRACTOR (No., street, city, county, State and ZIP Code)

The Jackson Laboratory 600 Maine St.

Bar Harbor, Maine 04609-1500

9A. AMENDMENT OF SOLICITATION

NO.

RFP 75N94025R00007 X

9B. DATED (SEE ITEM 11)

05/27/2025

10A. MODIFICATION OF

CONTRACT/ORDER NO.

CODE 9N885

FACILITY CODE

10B. DATED (SEE ITEM 13)

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

The above numbered solicitation is amended as set forth in item 14. The hour and date specified for receipt of Offers is extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning __1___ copy of the amendment in your business proposal; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (if required)

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

A. THIS CHANGE ORDER IS ISSUED PURSUANT TO FAR 52.243-2. THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT

ORDER NO. IN ITEM 10A.

B.THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b) and Contract ARTICLE B.4.

C.THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D.OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor _X_ is not, _ is required to sign this document and return _ copy in your business proposal to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

PURPOSE: Provide Amendment 001 as part of the RFP to remove Section III. Technical Specifications – C. Repository Maintenance, Breeding and Distribution 5.e. in its entirety.

DUE DATE: July 11, 2025, 4:30 PM Local Time (Eastern Standard Time (EST) (Unchanged).

All terms and conditions of the solicitation referenced in 9A and 9B, remain unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)

16A. NAME AND TITLE OF CONTRACTING OFFICER

Noor F. Shakeel

Contracting Officer

15B. CONTRACTOR/OFFEROR

BY ______________________________________________

(Signature of person authorized to sign)

15C. DATE SIGNED

16B. UNITED STATES OF AMERICA

BY ________________________________________

(Signature of Contracting Officer)

16C.DATE

SIGNED

June 18, 2025 RFP: 75N94025R00007 Amendment 001

Request for Proposal No. 75N94025R00007

“Repository of Mouse Models for Down Syndrome”

Amendment 001

Purpose: To remove the following section from the RFP in its entirety:

III. TECHNICAL SPECIFICATIONS

C. REPOSITORY MAINTENANCE, BREEDING and DISTRIBUTION

The Contractor shall maintain the "Repository of Mouse Models for Down Syndrome" (or "Mouse Repository") as elaborated below.

5. Distribute the animal models to qualified investigators approved by the NICHD.

e. The Contractor shall report the distribution of all mice each quarter and shall include the following information for each shipment of mice in the quarterly distribution and progress report. This report shall include, by task, a brief statement of the project’s progress during the preceding quarter; problems encountered and proposed solutions; initiatives scheduled; and an accounting of costs by subtask, project, and personnel. In addition, the distribution shall be described as follows:

Date of Investigator Request, Investigator’s e-mail, Investigator’s Name, Institution, Address, Phone number, Fax number, Federal Grant number, Federal Contract Number, Name of the strain of mice requested, Number of mice requested, Genotype, Sex, Breeding Pairs, Strain Name, Brief explanation of research project, Relevant Recent Publications indicating mouse strains studied, Investigator optimal delivery date, Pick-Up Information, Actual date shipped, and the Category that reflects the source of investigator funding (Federally-funded, not Federally-funded, or commercial). In addition, for each distribution, the Contractor shall identify whether the investigator works within the U.S. or at a foreign site, a list of new strains received or made available to investigators, and a summary of relevant investigator publications. This information will be maintained in the existing comprehensive Laboratory Information Management System (LIMS) for tracking, cataloguing, and documenting the quality and integrity of mice strains as well as the genotypes and phenotypes of mice, as well as updates on characterization of mouse strains. This is an existing system with descriptors added to the existing system for tracking and reporting. A computer system is not being developed under this contract.

The remainder of this Request for Proposal (RFP) remains unchanged until further notice.

END OF AMENDMENT