Combined Synopsis-Solicitation-8-25-2025.pdf

Combined Synopsis/Solicitation

Title: Isotopes for isotopically labeling proteins for solution Nuclear Magnetic Resonance (NMR) investigation.

Notice ID: 75N94025Q00198

Posted Date: August 25, 2025

Response Date: August 29, 2025

Product Service Code: 6505-Drugs and Biologicals

NAICS Code: 325412 – Pharmaceutical Preparation Manufacturing, size 1,300 employees

CONTRACTING OFFICE ADDRESS:

The Department of Health and Human Services, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Office of Acquisitions, 6710B Rockledge Drive, Rockville, MD 20892.

DESCRIPTION:

This is a combined synopsis/solicitation for commercial products or services prepared in accordance with the format in FAR 12.6 (Streamlined Procedures for Evaluation and Solicitation for commercial items) as applicable, and as supplemented with additional information included in this notice. This acquisition will be processed in accordance with FAR Part 13 – Simplified Acquisition Procedures (SAP) for Certain Commercial Products and Services. This announcement constitutes the solicitation; quotes are being requested and a separate written solicitation will not be issued. This solicitation number is 75N94025Q00198 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2025-04 (May 12, 2025).

The North American Industry Classification (NAICS) Code is 325412 and the business size standard is 1,300 employees.

This solicitation is NOT set aside for total small businesses.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) on behalf of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) intends to award a Firm Fixed Price (FFP) purchase order through full and open competition to fulfill this requirement.

STATEMENT OF NEED:

1.0 PURCHASE ORDER TITLE

Isotopes for isotopically labeling proteins for solution Nuclear Magnetic Resonance (NMR) investigation.

2.0 BACKGROUND

Structure/function studies of proteins, protein/protein complexes and protein complexes with other molecules (large like DNAs and RNA’s or small, like potential drug molecules) almost always requires proteins to be uniformly 13C/15N labeled, and most of the time proteins also need to be perdeuterated. To express these kinds of proteins, expressing media need 15N ammonium chloride and glucose in the form of 13C, 13C/deuterated and just deuterated as nitrogen and carbon sources and requires the medium prepared in D2O instead of H2O.

3.0 OBJECTIVE

The objective of this acquisition is to acquire isotopically labeled proteins.

4.0 CONTRACTOR REQUIREMENTS

The Contractor shall be responsible for the procurement and packaging of raw materials with the following items:

• 13C-glucose (CDLM-3813-10): 100 grams packaged in bottles of 2 grams each (i.e.

50 bottles).

• Deuterated glucose (DLM-2062-20): 100 grams. The product may be packaged in bottles of 5 grams each (i.e. 20 bottles) however the preferred packaging is in bottles of 2 grams each for a total of 50 bottles)

• 13C/deuterated glucose: 100 grams. The product may be packaged in bottles of 5 grams each (i.e. 20 bottles) however the preferred packaging is in bottles of 2 grams each for a total of 50 bottles)

• 15N ammonium chloride (NLM-467-50): 500 grams in bottles of either 10 grams each (i.e. 50 bottles) or 50 grams each (i.e. 10 bottles).

5.0 Task Areas

5.1 Task Area 1 – Delivery

Contractor shall deliver the described isotopes by October 2025 or no later than 30-days after receipt of award (ARO).

5.2 Task Area 2 –

Contractor shall arrange for shipment to the below specified location no later than 30 days after receipt of award (ARO).

National Institutes of Health, NIDDK, Building 5 Room B2-38 9000 Rockville Pike, Maryland 20892.

6.0 PURCHASE ORDER TYPE

This purchase order will be a firm fixed price.

7.0 PERIOD OF PERFORMANCE

Contractor shall deliver the described isotopes by October 30, 2025, or no later than 30-days after receipt of award (ARO).

8.0 PAYMENT TERMS

Payment will be made in one lump sum, in accordance with NIH Invoicing Instructions with

IPP.

9.0 REVIEW AND ACCEPTANCE

The Project Officer, Alternate Project Officer, or the Project Officer Supervisor will inspect delivery, installation, and/or testing to ensure the products provided conform with contract requirements. Invoices will be reviewed and approved by the program officer and or the Contracting Officer Representative (COR).

10.0 PROJECT OFFICER

The following Project Officer will represent the Government for the purpose of this Purchase Order:

TBD

BASIS FOR AWARD AND EVALUATION

Evaluation of quotes will be conducted in accordance with FAR 13.106-2 (b)(3) procedures.

The Government intends to award a Firm-Fixed-Priced Purchase Order from this solicitation to the responsible Offeror who provides the quote most advantageous to the Government.

The Government may reject any quote that is evaluated to be non-compliant with the solicitation requirements, unreasonably high or low in price, or reflects a failure to comprehend the requirement. The Government reserves the right to make no award if quotes do not meet the requirements of this solicitation.

Award will be made to the contractor providing the most advantageous quote to the government, technical factors and cost/price considered.

Vendors will be evaluated on their capabilities to provide the product to the specifications described in the Contractor Requirements section.

SUBMISSION & GENERAL INSTRUCTIONS

This Request for Quotation (RFQ) does not commit the Government to pay any cost for preparation and submission of a quote. In addition, the Contracting Officer is the only individual who can legally commit to the expenditure of public funds in connection with this proposed acquisition. By submitting a quote in response to this solicitation, it is understood that your organization’s quote shall become a part of the official contract file. The Government is not responsible for locating or securing any information which is not identified in the quote.

Quotes must contain a statement to the effect that the offer is valid for a period of at least 30 days from the date of receipt by the Government.

All responsible sources may submit a quotation, which if timely received, shall be considered by the agency.

Quote submittal must also include the following:

• All submittals must include a completed FAR Provision 52.204-24, 52.204-26 and 52.213-3 unless already completed in the System for Award Management (SAM). If already provided in the vendor’s SAM.gov profile, and do not conflict with the requirements as stated in this solicitation, please provide a statement to the effect of “Provisions 52.204-24, 52.204-26 and 52.213-3 are complete and accurate per our SAM.gov registration dated 00/00/0000.

• All attachments must be in Microsoft Word or Adobe Portable Format (PDF).

• All correspondence must have Notice ID “75N94025Q00198” included in the subject line.

The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications – Commercial Products and Commercial Services (May 2024) (Deviation Feb 2025) with its offer. The provisions of FAR Clause

52.212-1 Instructions to Offerors – Commercial Items; FAR Clause 52.212-2, Evaluation – Commercial Items - FAR Clause 52.212-4, Contract Terms and Conditions – Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders – Commercial Products and Commercial Services (Jan 2025) (Deviation Feb 2025); FAR Clause 52.204-8 Annual Representations and Certifications (Jan 2025) (Deviation Feb 2025) – Deviation for Simplified Acquisitions apply to this acquisition.

Note: The contractor/offeror must provide a completed copy of FAR 52.204-24, "Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment" with their quote in response to this solicitation. The clauses are available in full text at http://www.acquisition.gov/far/

Note: In order to receive an award, contractor must have an active registration in www.sam.gov for all awards and shall continue to have an active registration until time of award, during performance, and through final payment. Failure to maintain an active SAM registration can jeopardize the award or result in non-payment. Lack of valid registration in SAM will make an offeror ineligible for award.

The offeror must include their Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size.

Note: “System updates may lag policy updates. The System for Award Management (SAM) may continue to require entities to complete representations based on provisions that are not included in agency solicitations, including 52.223-22, Public Disclosure of Greenhouse Gas Emissions and Reduction Goals— Representation, and paragraph (t) of 52.212-3, Offeror Representations and Certifications—Commercial Products and Commercial Services. Agencies will not consider or use these representations. Entities are not required to, nor are they able to, update their entity registration to remove these representations in

SAM.”

QUOTATION SUBMITTAL

Quotations submitted in response to this solicitation must be submitted via email no later than Friday, August 29, 2025, by 10:00 AM Eastern Standard Time to the point of contact listed below:

Name: Usha Raman Contracting Officer Email: ramanu2@mail.nih.gov

Note: It’s the Offeror’s responsibility to read the RFQ and all related documents carefully.

Additionally, it is the Offeror’s responsibility to ensure/verify the Government receives its http://www.acquisition.gov/far/ http://www.sam.gov/ mailto:ramanu2@mail.nih.gov submission on or before the date/time specified. The Government reserves the right to not accept any late quotes. Please do not wait until the deadline to submit your quotation.

LIST OF ATTACHMENTS:

Attachment 1 – Visit NIH Vendor Memo

Attachment 2 – FAR 52.212-3 (MAY 2024) [(DEVIATION FEB 2025)]

Attachment 3 – FAR 52.212-5 (JAN 2025) [(DEVIATION FEB 2025)]

Attachment 4 – FAR 52.223-23 (MAY 2024) [(DEVIATION FEB 2025)]

Attachment 5 – NIH Invoicing Instructions with IPP (MAR 2023)