75N94025Q00116.Combined Synopsis Solicitation.pdf

COMBINED SYNOPSIS / SOLICITATION WORKFORM

(1) Action Code: Combined Synopsis/Solicitation

(2) Date: 6/30/2025

(3) Year: 2025

(4) Contracting Office Zip Code: 20892

(5) Project Service Code: 6640 – LABORATORY EQUIPMENT AND SUPPLIES:

(6) Contracting Office Address:

6710B Rockledge Drive Bethesda, MD 20892

(7) Subject/Title: Acquisition of an H-Cube Mini System

(8) Proposed Solicitation Number: 75N94025Q00116

(9) Closing Response Date: 7/14/2025

(10) Contact Point: Amber Harris

(11) Contract Award and Solicitation Number: TBD

(12) Contract Award Dollar Amount: TBD

(13) Contract Line Item Number(s): TBD

(14) Contractor Award Date: TBD

(15) Contractor Name: TBD

(16) Description: (Background)

(i) “This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested and a written solicitation will not be issued.”

(ii) The solicitation number is 75N94025Q00116 and the solicitation is issued as a Request for Quote (RFQ).

(iii) The solicitation document, the incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2025-04 Effective June 11, 2025.

(iv) The associated NAICS code is 334516, Other Scientific and Technical Consulting

Services, and the small business size standard is 1,000. The acquisition is being conducted in accordance with the procedures of FAR Part 12 and FAR Part 13.

(v) The Contractor Requirements are listed below:

1.0 PURCHASE ORDER TITLE

Acquisition of an H-Cube Mini System

2.0 BACKGROUND

The NIDDK is involved in the discovery and development of new molecules with medicinal value or for applications to diagnostics. Some of these molecules have the potential to become therapeutics or to be used as important components in diagnostic applications that signal the presence of disease. Applications in either area are of great benefit to human health and thus to NIDDK's mission. Research conducted in NIDDK involves synthesis and purification of biologically active molecules called thyclotides.

This purchase is urgently needed to obtain new instrumentation required to synthesize thyclotides, specifically the monomeric units used to build thyclotides. Each thyclotide must be individually made, and without this instrument the lab won't be able to perform research on the properties of thyclotides..

3.0 OBJECTIVE

The objective of this requirement is to procure a ThalesNano Nanotechnology Inc. H- Cube Mini Plus Continuous flow hydrogenation reactor. This is required in order for the NIDDK to synthesize thyclotide molecules in Dr. Appella's Lab NIDDK/DIR/LBC/SBMS;

this request is for existing research that began prior to 1/20/25. This acquisition is being conducted using the authority at FAR 52.211-6 Brand Name or Equal.

4.0 SALIENT / REQUIRED FEATURES AND SPECIFICATIONS

The following product features/characteristics are required for this requirement:

A specialized H-cube mini system with continuous flow hydrogenation reactor is needed to synthesize thyclotide molecules. A dedicated H-cube mini system that can synthesize thyclotides and can use protocols to make thyclotides. The Contractor shall provide a certified engineer to service the instrumentation when problems arise while fixing the interface between the instrument and the computer. The Contractor shall also provide guidance to help avoid problems in the future.

Software associated with the H-Cube Mini Plus shall have a warrantee of 12 months after installation.

Description Quantity H-Cube Mini Plus 1 70 mm CatCart holder and cup with replacement tube SS

30x4 mm (2.5% Pd + 2.5% (6-pieces-kit)Pt)/C

30x4 mm 10%Pd/C (6-piece-kit) 3

4.1 TRAINING

The manufacture shall provide installation and new user training. Training will be concurrent with installation and will be coordinated with the NIDDK POC.

5.0 PURCHASE ORDER TYPE

This Purchase Order is to be a firm fixed price.

6.0 PERIOD OF PERFORMANCE AND PAYMENT BREAKDOWN

Delivery Within 90 Days of Award

Payment will be made Monthly in Arrears.

7.0 INSPECTION AND ACCEPTANCE

The Project Officer or the Project Officer Supervisor will perform inspection and acceptance of materials and services to be provided. For equipment orders, inspection and acceptance will be done AFTER All materials are unpacked, installed, and test run for operation. Receiving will be completed no later than 7 days following date of Delivery.

Acceptance and Delivery will be complete once the signed packing slip is provided to the Vendor.

Inspection and acceptance will be performed at the place of installation –

The National Institutes of Health, NIDDK, 9000 Rockville Pike, Bethesda, Maryland 20892.

For services, invoices will be approved by the Project officer and or COR according to payment terms in the resultant purchase order.

(vi) The provision at FAR clause 52.212-1, Instructions to Offerors – Commercial Items, applies to this acquisition.

30x4 mm 10%Pt/C (6-piece-kit) 1 30x4 mm 20% Pd(OH)2/C (6-piece-kit) 3 30x4 mm 5% Pd/C (6-piece-kit) 3 30x4 mm 5% Pd/CaCO3 (poisoned withlead) (6-pieces-kit)

30x4 mm 5% Pt/C (6-pieces-kit) 1 30x4 mm Amberlyst 36 resin (6-pieces-kit)

30x4 mm Raney Nickel (6-piece-kit) 1 30x4 mm Tetrakis (TPP)-palladium 6 Remote installation 1 Shipping and handling 1

(vii) The provision at FAR clause 52.212-2, Evaluation – Commercial Items, is applicable.

Award will be made to the contractor providing the most advantageous quote to the Government. Technical factors and price considered with technical factors outweighing price.

Specifically, the following technical factors will be evaluated:

i. The vendor will be evaluated on their quoted product meeting the specifications under section 4.0 SALIENT / REQUIRED FEATURES AND SPECIFICATIONS.

ii. The Offeror should note that the evaluation criteria listed in order of importance are:

A. Technical – The services proposed by the vendor meets the requirements in the SOW

B. Cost/Price

The technical factors are as follows:

The evaluation will be based on the demonstrated capabilities of the prospective Offeror in relation to the needs of the project as set forth in the Statement of Work. The merits of the proposal will be evaluated carefully and will be deemed Acceptable or Unacceptable. The proposal must document the feasibility of successful implementation of the requirements of the Statement of Work. The Offeror must submit information sufficient to evaluate the proposal based on the detailed factors listed in section 4.0 SALIENT / REQUIRED FEATURES AND

SPECIFICATIONS.

Evaluation Criteria Acceptable Unacceptable

Technical The services proposed by the vendor meet the requirements in the SOW

Summary Overall Rating (Overall Risk)

Cost/Price Offerors will be evaluated based upon cost/price completeness and accuracy to determine the validity of the price, realism, reasonableness, and risk.

Technical Evaluation Rating Definitions

(viii) FAR clause 52.212-3, Offeror Representations and Certifications – Commercial Items, is applicable. An offeror shall complete only paragraphs (b) of this provision if the offeror has completed the annual representations and certificates electronically via http://www.acquisition.gov If an offeror has not completed the annual representations and certifications electronically at the System for Award Management (SAM) website, the offeror shall complete only paragraphs (c) through (p) of this provision.

(x) FAR clause at 52.212-4, Contract Terms and Conditions – Commercial Items, applies to this acquisition.

(xi) FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders – Commercial Items, applies to this acquisition. Including the following clauses and Prohibitions:

i. FAR 52.204-8, Annual Representations and Certifications (JAN 2025)

(DEVIATION FEB 2025)

ii. 52.204-10, Reporting Executive Compensation and First-Tier

Subcontract Awards

iii. 52.209-6, Protecting the Government’s Interest When Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment

iv. 52.209-9, Updates of Publicly Available Information Regarding

Responsibility Matters

v. 52.211-6 Brand Name or Equal

vi. FAR 52.212-3, Offeror Representations and Certifications—Commercial

Products and Commercial Services (MAY 2024) (DEVIATION FEB 2025)

vii. FAR 52.212-5, Contract Terms and Conditions Required To Implement

Statutes or Executive Orders—Commercial Products and Commercial Services (JAN 2025) (DEVIATION FEB 2025)

viii. FAR 52.213-4, Terms and Conditions—Simplified Acquisitions (Other Than Commercial Products and Commercial Services) (JAN 2025)

(DEVIATION FEB 2025)

ix. 52.219-4, Notice of Price Evaluation Preference for HUBZone Small Business Concerns

x. 52.219-8, Utilization of Small Business Concerns

xi. 52.219-28, Post Award Small Business Program Representation

xii. 52.222-50 Combating Trafficking in Persons

xiii. FAR 52.223-1 Biobased Product Certification (MAY 2024) (DEVIATION

FEB 2025)

xiv. FAR 52.223-2 Reporting of Biobased Products Under Service and

Construction Contracts (MAY 2024) (DEVIATION FEB 2025)

xv. FAR 52.223-10 Waste Reduction Program (MAY 2024) (DEVIATION

FEB 2025)

Rating Definition Acceptable Proposal meets requirements and indicates an adequate approach and understanding of the requirements, and risk of unsuccessful performance is no worse than moderate.

Unacceptable Proposal does not meet requirements of the solicitation, and thus, contains one or more deficiencies, and/or risk of unsuccessful performance is unacceptable.

http://www.acquisition.gov/

xvi. 52.223-18, Encouraging Contractor Policies to Ban Text Messaging while Driving

xvii. FAR 52.223-23, Sustainable Products and Services (MAY 2024

(DEVIATION FEB 2025))

xviii. 52.225-13, Restrictions on Certain Foreign Purchases

xix. FAR 52.244-6, Subcontracts for Commercial Products and Commercial

Services (JAN 2025) (DEVIATION FEB 2025)

Additional Clauses:

i. 52.232-33, Payment by Electronic Funds Transfer— System for Award Management (OCT 2018) (31 U.S.C. 3332).

ii. 52.232-39, Unenforceability of Unauthorized Obligations

(xii) Additional Contract Requirements:

The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

One (1) copy of the response is required and must be in Microsoft Word or Adobe

PDF format using 11- point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested.

Vendor/Contractor Must be able to accept payments via IPP (Invoice Processing

Platform) The contractor may submit a request for an exception. See below for IPP, IPP helpdesk information and applicable Health and Human Services addendum clause.

INVOICING PROCESSING PLATFORM (IPP) In compliance with the Office of

Management and Budget (OMB) M-15-19 memorandum "Improving Government Efficiency and Saving Taxpayer Dollars through Electronic Invoicing" directing Federal agencies to adopt electronic invoicing as the primary means to disburse payment to vendors. Invoices submitted under any award resulting from this solicitation will be required to utilize the Invoice Processing Platform (IPP) in accordance with HHSAR 352.232-71, Electronic Submission and Processing of Payment Requests" IPP is a secure, web-based electronic invoicing system provided by the U.S. Department of the Treasury's Bureau of the Fiscal Service, in partnership with the Federal Reserve Bank of St. Louis (FRSTL). Respondents to this solicitation are encouraged to register an account with IPP if they have not already done so. If your organization is already registered to use IPP, you will not be required to re-register however, we encourage you make sure your organization and designated IPP user accounts are valid and up to date. The IPP website address is:

https://www.ipp.gov If you require assistance registering or IPP account access, please contact the IPP Helpdesk at (866) 973-3131 (M-F 8AM to 6PM ET), or IPPCustomerSupport@fiscal.treasury.gov Note: Should an Offeror feel that use of the IPP would be unduly burdensome, the response to this solicitation should include an explanation of this position for a determination by the contracting officer.

HHSAR 352.232-71 Electronic Submission of Invoice Payment Requests (Feb 2022) will apply when this requirement is solicited and awarded. As stated: (a) Definitions.

As used in this clause, Payment request means a bill, voucher, invoice, or request for contract financing payment with associated supporting documentation. The payment request must comply with the requirements identified in FAR 32.905(b), "Content of Invoices" and the applicable Payment clause included in this contract. (b) Except as provided in paragraph (c) of this clause, the Contractor shall submit payment requests electronically using the Department of Treasury Invoice Processing Platform (IPP) or successor system. Information regarding IPP, including IPP Customer Support contact information, is available at www.ipp.gov or any successor site. (c) The Contractor may submit payment requests using other than IPP only when the Contracting Officer authorizes alternate procedures in writing in accordance with HHS procedures. (d) If alternate payment procedures are authorized, the Contractor shall include a copy of the Contracting Officer's written authorization with each payment request. (END OF CLAUSE)

(xiii) The Defense Priorities and Allocations System (DPAS) and assigned rating are not applicable.

(xiv) Offers shall be submitted via email to amber.harris@nih.gov and must reference 75N94025Q00116 in the subject line.

(17) Place of Contract Performance:

National Institute of Health, NIDDK Bethesda MD 20892

(18) Set-aside Status: This requirement is not set aside for small business.

mailto:amber.harris@nih.gov