SON _NanoString (Draft).pdf

STATEMENT OF NEED (SON)

1.0 TITLE

Brand Name NanoString CosMx Spatial gene expression library preparation kits (6K)

2.0 BACKGROUND

The Department of Health and Human Services, National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research’s (CCR), Spatial Tumor Biology Section of the Cancer Data Science Laboratory (CDSL) focuses on tumor heterogeneity and tumor evolution with the goal of improving early detection and therapeutics for liver cancer. It is well known that cellular functions are closely related to the spatial context of the cells. Thus, resolving the spatial information of tumor cells and immune cells would be critical to understand tumor heterogeneity and tumor evolution. The CDSL to date has used NanoString’s CosMx SMI platform for the assessment of spatial information of tumors due to its ability to profile the expression of ~6,000 genes with an additional layer of spatial information. To continue these research efforts and to ensure scientific comparability of research results, the CDSL requires additional CosMx SMI platform reagents.

3.0 TYPE OF ORDER

This is a Firm Fixed-Price Purchase Order.

4.0 SPECIAL ORDER REQUIREMENTS

4.1 PRODUCT FEATURES/SALIENT CHARACTERISTICS

The Contractor shall provide the following items:

Item Description Qty 1 CMx RNA Inst Buffer Kit, Med 4 2 CMx RNAse Inhib, 2 sl Kit 4 3 CMx Slide Prep Kit, FFPE RNA 2 4 CMx Hs Univ Cell Seg Kit, RNA 2 5 CMx Hs CD68 Marker Kit, RNA 2 6 CMx Hs 6K Discovery RNA Panel 2 7 CosMx SMI Flow Cell, 4 sld 2 8 CMx Cleaning Tray Kit 4 9 CMx RNA 6Kplx 2sl Img Tray Kit 3 10 S&H 1 - 8 Kits / Slides 1

5.0 DELIVERY

Delivery of specified items shall be delivered within thirty (30) calendar days of the purchase order award. All shipping/handling shall be F.O.B Destination, and pricing shall be included in the quote.

The supplies shall be delivered to the Technical Point of Contact (TPOC), TBD at award, at the following address:

NIH/NCI/CDSL

9000 Rockville Pike Bethesda, MD 20892

5.1 DELIVERY GUIDEANCE

The Contractors shall communicate and follow instructions from the Technical Point of Contact (TPOC) to coordinate delivery.

The Contractor shall direct all courier and delivery services – including those not operated by the Contractor (e.g. FedEx, USPS, UPS) – to follow the instructions in this section.

All companies delivering to the NIH main campus must comply with Commercial Vehicle Inspection Facility (CVIF) access procedures. Upon arrival, the CVIF will provide a list of buildings and loading docks to delivery personnel.

Deliveries will be logged in at the loading dock, and the loading dock contractor or Government personnel will attempt to contact the TPOC listed on the package. In the event that the TPOC is unable to accept the package, the delivery shall not be left at the loading dock station. The delivery must be returned to the Contractor, and the Contractor must coordinate with the TPOC to deliver on another date at no additional cost.

Deliveries can only be made between 6:00 a.m. and 4:00 p.m. EST, Monday – Friday, excluding federal holidays.

6.0 WARRANTY

In addition to the Implied warranty contained in FAR Clause 52.212-4, quoters are encouraged to provide express warranties. The warranty shall at a minimum ensure that all items conform to the seller’s specifications provided for a period of ninety (90) days after delivery, or until the expiration date listed on individual products. Should items not conform to the specifications provided with the product, the vendor shall provide for a 1:1exchange of the same product at no additional cost to the Government. The warranty shall not exclude or limit the Governments rights for an Implied warranty as established in the terms and conditions of clause 52.212-4.

7.0 INSPECTION AND ACCEPTANCE

Pursuant to FAR Clause 52.212-4, all items to be delivered in relation to this Purchase Order are subject to final inspection and acceptance by an authorized representative of the Government. The authorized representative of the Government is the TPOC who is responsible for inspection and acceptance of all services, materials, or supplies to be provided by the Contractor.

8.0 TECHNICAL POINT OF CONTACT

The Technical Point of Contact (TPOC) is responsible for inspection and acceptance of all items/services in relation to this requirement and will serve as the Governments primary point of contact throughout the duration of the requirement. All efforts must be coordinated with this individual. The TPOC for this requirement is:

TBD (upon award)

Note: The TPOC has limited authority as defined within this Statement of Need. They do not have the authority to commit or obligate Government funds or make changes to the terms and conditions of the purchase order. As such, any changes to the purchase order must be performed by a warranted Government Contracting Officer with appropriate delegated authority to do so.