SON - BioAssemblyBOT - NOI SS.docx

STATEMENT OF NEED (SON)

TITLE

Purchase of One (1) Advanced Solutions Life Sciences BioAssemblyBOT 200 Cell DIVE Automation Workstation

BACKGROUND

The Thoracic and GI Malignancies Branch (TGMB), National Cancer Institute, National Institutes of Health, conducts research in the treatment of lung cancer, a disease with a very low response and survival rate. The discovery of new therapeutic targets and more effective immunotherapies requires an extraordinary deep understanding of complex interactions in the tumor microenvironment.

Traditional investigation methods, such as flow cytometry and low-plex histology, lack the ability to measure cells, mediators, and the microbiota simultaneously while also collecting critical spatial information.

To deepen the investigations of these complex interactions, TGMB requires the upgrade of a hyperplexed immunofluorescence imager, Cell DIVE (Leica Microsystems Inc.), with a BioAssemblyBOT 200 Cell DIVE automation workstation (Advanced Solutions Life Sciences, LLC). This robotic component will significantly increase experimental efficiency and accuracy in staining procedures. In addition, the bioprinting capabilities of this component will enable TGMB to create disease models for drug discovery.

TYPE OF ORDER

This shall be issued as a Firm Fixed-Price Purchase Order.

SPECIAL ORDER REQUIREMENTS

PRODUCT FEATURES/SALIENT CHARACTERISTICS

The following minimum product features/characteristics are required for the automated workstation:

1. Must be compatible with Leica Cell DIVE imager: the automated workstation which contains a robotic arm, liquid transfer pipettes, and plate holder. The size is around 42.9 x 36.8 x 72.2 inch.

2. Must be able to process 15 slides at a time in the Leica Cell DIVE ClickWell Coverslip-free slide holder.

3. Must be able to perform pipetting to add solutions at microliter level to Leica Cell DIVE ClickWell.

4. Gentle mix solutions in Cell DIVE ClickWell glass slide holder

5. Control software needs to communicate with the Leica Cell DIVE imager’s control program without further modification.

6. Able to use multiple different tools in a single workflow.

7. The robotic arm and the universal tool adapter can be adjusted to work for transporting Cell DIVE ClikcWell glass slide holder or adding reagents into the holder.

8. Must have an enclosure suited to connect with the Leica Cell DIVE imager

9. Must have four-axis robot to autonomously conduct all workflow steps without user interaction

10. Workflow, including slide holder transportation, adding/removing/mixing reagents, can be adjusted in different combination sequences

11. Capable of bioprinting three-dimensional tissue models and of bioprinting on living tissue

1.1 DELIVERY / INSTALLATION

The Contractor shall deliver all supplies FOB Origin no later than 90 days after receipt of order (ARO). Upon delivery, the Contractor shall notify the respective NCI Technical Point of Contact, TBD at award [Chen Zhao, 41 Center Dr, Bldg 4, Rm 109, 301-646-8331, chen.zhao@nih.gov], to schedule installation dates and times. Installation shall occur within one (1) business day of delivery and shall be performed by, or under the direct supervision of, an Original Equipment Manufacturer (OEM) certified technician. Equipment shall be delivered to and installed at the following address:

NIH, Bldg. 41, Room D702A, 41 Medlars Drive, Bethesda, MD 20892

Note that access to the NIH campus is restricted. As such all Contractor personnel will be required to access campus via designated entrances where they are subject to security screening. Also, due to the current COVID-19 Pandemic there maybe additional access restrictions. Please refer to the NIH Security and Access site for more details: (www.nih.gov/about-nih/visitor-information/campus-access-security).

responsible in the event charges are not included in the quote.

• Installation charges must be included in the quote.

4.3 WARRANTY

The Contractor shall warrant that any instruments, equipment, components, or other supplies (“Supplies”) procured by this purchase are free of defects in design, material, or manufacture for a minimum of 12-months from date of installation.

The Contractor shall warrant that all consumables or expendable parts are free of defects in design, material, or manufacture for a period of at least 90 calendar days from date of acceptance by the Government.

Supplies which are repaired or replaced shall be warranted for the remainder of the initial warranty period or for 90-days – whichever is greater. 2-months of Technical Support shall be included in the warranty.

4.4 INSPECTION AND ACCEPTANCE

Pursuant to FAR clause 52.212-4, all work described in the SOW to be delivered under this purchase order is subject to final inspection and acceptance by an authorized representative of the Government. The authorized representative of the Government is the NCI Technical Point of Contact:

TPOC: TBD

The TPOC is responsible for inspection and acceptance of all services, materials, or supplies to be provided by the Contractor.

Regardless of format, all digital content or communications materials produced as a deliverable under this purchase order, shall conform to applicable Section 508 Standards to allow Federal employees and members of the public with disabilities to have access to and use of information and data that is comparable to the access to and use of information and data by Federal employees or by members of the public who are not individuals with disabilities. Remediation of any materials that do not comply with the applicable Section 508 requirements as set forth below, shall be the responsibility of the Contractor.

HHS guidance regarding accessibility of documents can be found at:

https://www.hhs.gov/web/section-508/accessibility-checklists/index.html

Federal Government-wide guidance regarding accessibility of documents can be found at https://www.section508.gov/, including the documents describing the preferred method of authoring and testing documents produced in Microsoft Word 2013 or later, Microsoft Excel, and files formatted as PDF.

4.5 TRAINING

The Contractor shall provide one (1) day training session for up to four (4) NCI staff at the location of delivery. Training shall take place within seven (7) days of equipment installation and shall be facilitated by a factory-trained product specialist. Training shall include an overview of setup approaches, maintaining instrument settings, establishing operational voltages, and software usage for custom instrument configurations, as well as a demonstration of the performance. All training expenses, including materials and or travel expenses, shall be included in the quoted price.

PAYMENT

Payment shall be made after delivery/installation and acceptance of the equipment by the TPOC under this order.

The following clause is applicable to all Purchase Orders, Task or Delivery Orders, and Blanket Purchase Agreement (BPA) Calls: Prompt Payment (Jan 2017) FAR 52.232-25. Highlights of this clause and NIH implementation requirements follow:

I. Invoice Requirements

A. An invoice is the Contractor's bill or written request for payment under the contract for supplies delivered or services performed. A proper invoice is an "Original" which must include the items listed in subdivisions 1 through 12, below, in addition to the requirements of FAR 32.9. If the invoice does not comply with these requirements, the Contractor will be notified of the defect within 7 days after the date the designated billing office received the invoice (3 days for meat, meat food products, or fish, and 5 days for perishable agricultural commodities, dairy products, edible fats, or oils) with a statement of the reasons why it is not a proper invoice. (See exceptions under II., below.) Untimely notification will be considered in the computation of any interest penalty owed the Contractor.

1. Vendor/Contractor: Name, Address, Point of Contact for the invoice (Name, title, telephone number, e-mail and mailing address of point of contact).

2. Remit-to address (Name and complete mailing address to send payment).

3. Remittance name must match exactly with name on original order/contract. If the Remittance name differs from the Legal Business Name, then both names must appear on the invoice.

4. Invoice date.

5. Unique invoice #s for all invoices per vendor regardless of site.

6. NBS document number formats must be included for awards created in the NBS: Contract Number; Purchase Order Number; Task or Delivery Order Number and Source Award Number (e.g., Indefinite Delivery Contract number; General Services Administration number); or, BPA Call Number and BPA Parent Award Number.

7. Unique Entity Identifier (UEI) which is in the System for Award Management (SAM) and replaces the Dun & Bradstreet Data Universal Numbering System (DUNS) number.

8. Federal Taxpayer Identification Number (TIN). In those rare cases where a contractor does not have a UEI number or TIN, a Vendor Identification Number (VIN) must be referenced on the invoice. The VIN is the number that appears after the contractor’s name on the face page of the award document.

9. Identify that payment is to be made using a three-way match.

10. Description of supplies/services that match the description on the award, by line billed.*

11. Freight or delivery charge must be billed as shown on the award. If it is included in the item price do not bill it separately. If identified in the award as a separate line item, it must be billed separately.

12. Quantity, Unit of Measure, Unit Price, Extended Price of supplies delivered or services performed, as applicable, and that match the line items specified in the award.*

NOTE: If your invoice must differ from the line items on the award, please contact the Contracting Officer before submitting the invoice. A modification to the order or contract may be needed before the invoice can be submitted and paid.

Shipping costs will be reimbursed only if authorized by the Contract/Purchase Order. If authorized, shipping costs must be itemized. Where shipping costs exceed $100, the invoice must be supported by a bill of lading or a paid carrier's receipt.

B. The Contractor shall submit invoices to the Department of Treasury’s Invoice Processing Platform (IPP) at https://www.ipp.gov with a copy to the approving official as directed below.

The Contractor shall submit a copy of the electronic invoice to the following Approving Official (Purchasing Agent) and Technical Point of Contact:

Approving Official: Purchasing Agent

TBD: Name Email

Technical Point of Contact

B. Determination of interest and penalties due will be made in accordance with the provisions of the Prompt Payment Act, as amended, the Contract Disputes Act, and regulations issued by the Office of Management and Budget.

IV. PROVIDING ACCELERATED PAYMENT TO SMALL BUSINESS SUBCONTRACTORS, FAR 52.232-40 (November 2021)

(a) Upon receipt of accelerated payments from the Government, the Contractor shall make accelerated payments to its small business subcontractors under this contract, to the maximum extent practicable and prior to when such payment is otherwise required under the applicable contract or subcontract, after receipt of a proper invoice and all other required documentation from the small business subcontractor.

(b) The acceleration of payments under this clause does not provide any new rights under the Prompt Payment Act.

(c) Include the substance of this clause, including this paragraph (c), in all subcontracts with small business concerns, including subcontracts with small business concerns for the acquisition of commercial products or commercial services.

(End of Clause)

V. HHSAR 352.232-71 Electronic Submission of Payment Requests (February 2, 2022)

(a) Definitions. As used in this clause— Payment request means a bill, voucher, invoice, or request for contract financing payment with associated supporting documentation. The payment request must comply with the requirements identified in FAR 32.905(b), ‘‘Content of Invoices’’ and the applicable Payment clause included in this contract.

(b) Except as provided in paragraph (c) of this clause, the Contractor shall submit payment requests electronically using the Department of Treasury Invoice Processing Platform (IPP) or successor system. Information regarding IPP, including IPP Customer Support contact information, is available at www.ipp.gov or any successor site.

(c) The Contractor may submit payment requests using other than IPP only when the Contracting Officer authorizes alternate procedures in writing in accordance with HHS procedures.

(d) If alternate payment procedures are authorized, the Contractor shall include a copy of the Contracting Officer’s written authorization with each payment request.

(End of Clause)