75N91024-CSS-6904112.pdf

75N91024-CSS-6904112 Page 1 of 7

GENERAL INFORMATION/CLASSIFICATION

Title: Brand Name or Equal: Meso Scale Discovery MESO QuickPlex SQ

120MM Reader Notice Type: Combined Synopsis / Solicitation Solicitation Number: 75N91024-CSS-6904112 Posted Date: 04/17/2024 Response Date: 04/26/2024 PSC Code: 6640 – Laboratory Equipment and Supplies NAICS Code: 334516 – Analytical Laboratory Instrument Manufacturing

ISSUED BY:

National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Acquisitions (OA)

DESCRIPTION:

The Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research (CCR) has a need for one (1) Meso Scale Discovery MESO QuickPlex SQ 120MM Reader.

This is a Combined Synopsis/Solicitation for commercial items, prepared in accordance with the format in Federal Acquisition Regulation (FAR) subpart 12.6, as supplemented with additional information included in this notice, and shall be processed in accordance with (FAR Part 13– Simplified Acquisition Procedures / FAR 13.5 - Simplified Procedures for Certain Commercial Products and Commercial Services). This announcement constitutes the only solicitation that will be provided in relation to the stated need contained herein. This solicitation is issued as a Request for Quote (RFQ) and includes applicable provisions and clauses in effect through FAR Federal Acquisition Circular (FAC) 2024-02 (12/22/2023).

The requirement’s suggested North American Industry Classification System (NAICS) code is 334516 – Analytical Laboratory Instrument Manufacturing with a size standard of 1000 Employees.

One Firm-Fixed-Priced award is anticipated to be made as a result of this solicitation.

***PLEASE REVIEW THE ATTACHED DOCUMENTS***

75N91024-CSS-6904112 Page 2 of 7

QUOTE SUBMISSION / EVALUATION (52.212-1 ADDENDA)

GENERAL INSTRUCTIONS

This Request for Quotation (RFQ) does not commit the Government to pay any cost for the preparation and submission of a quote. In addition, the Contracting Officer is the only individual who can legally commit the Government to the expenditure of public funds in connection with this proposed acquisition.

By submitting a quote in response to this solicitation, it is understood that your firm’s quote shall become a part of the official contract file. The Government is not responsible for locating or securing any information which the Quoter does not include or identify in their quotation.

QUESTION SUBMISSIONS

Please submit questions concerning this RFQ via email by no later than 12:00 P.M. EST on April 19, 2024 (04/19/2024) to the point of contact listed below:

Name: Miguel Diaz Contracting Officer Email: miguel.diaz@nih.gov

Note: Questions submitted by a method other than email will not be accepted. Any questions received after the specified cut-off time and date above will not be accepted or answered unless at the Contracting Officers discretion is deemed necessary. Additionally, all questions and answers of common interest will be provided to all prospective offerors via an amendment to the posting. All emails must include the Solicitation number “75N91024-CSS-6904112” in the subject line.

QUOTATION SUBMISSIONS (Note: Recommended Quote Submission template shown in Section

2.0 – BRAND NAME PRODUCTS on Page 5 of 6.)

Quotations submitted in response to this solicitation must be submitted via email no later than 12:00 P.M. EST on April 26, 2024 (04/26/2024) to the point of contract listed below:

Name: Miguel Diaz Contracting Officer Email: miguel.diaz@nih.gov

Quoters may submit more than one quote. If multiple quotes are provided, the Government will evaluate each quote separately. All quotations shall provide enough information for the Government to conduct a thorough evaluation of the quotes provided, and the quoter’s ability to fulfill the stated needs within this RFQ. All quoters must be registered in SAM.gov and be eligible for all awards (FAR 52.204-7 System for Awrad Management). Quoters that do not have an active SAM.gov registration with an eligibility for all awards will not be considered for award. At a minimum, all quotes shall include in the following:

1. Company Name

2. Point of Contact (POC) (including telephone and email address) for individuals authorized to commit on behalf of their organization. Including name, address, and telephone number of the offeror.

3. Company’s System for Award Management Unique Entity Identifier (UEI)

4. Socio-economic status (8(a), SDVOSB, VOSB, Woman-Owned, Other… etc.).

5. Provide product information such as brochures, manuals, etc. to demonstrate that the proposed equipment is:

mailto:miguel.diaz@nih.gov mailto:miguel.diaz@nih.gov

75N91024-CSS-6904112 Page 3 of 7

a. equal to or greater than the minimum required features/characteristics listed in Section 1.0

SPECIAL ORDER REQUIREMENTS.

b. the brand name equipment listed in Section 2.0 BRAND NAME PRODUCTS.

6. Provide any available pricing information including all discount terms. Include a statement to the effect that pricing is firm for a period of at least 60 days from the date of receipt thereof by the Government.

7. Terms of any Express Warranty.

8. Provide information pertaining to the origin of the equipment, and where it’s manufactured.

9. A completed copy of the representations and certifications at Federal Acquisition Regulation

(FAR) 52.212-3 (see FAR 52.212-3(b)) for those representations and certifications that the offeror shall complete electronically) (See attachment to the Combined Synopsis Solicitation).

10. A technical description of the items/services being offered in sufficient detail to evaluate compliance with the requirements in the solicitation. This may include product literature, or other documents, if necessary.

Note: It’s the Quoter’s responsibility to read the RFQ and all related documents carefully. Additionally, it is the Quoter’s responsibility to ensure/verify the Government receives its submission on or before the date/time specified above. The Government reserves the right to not accept any late quotes, any quote that does not provide items/services requested, or quotes that do not conform to the requirements of the RFQ. Please do not wait until the deadline to submit your quotation. Quotes submitted by any other means other than email will not be accepted. All emails must include the Solicitation number “75N91024-CSS-6826350” in the subject line.

BASIS FOR AWARD AND EVALUATION

An award shall be made to the firm that submits the Lowest Price Technically Acceptable (LPTA) quote that is technically acceptable in accordance with the required need outlined in the Statement of Need (SON). A technically acceptable quote is one in which the quoter(s) complies with the requirements in the (SON) and does not take exception, nor object to the terms of the RFQ. Quotes that are not technically acceptable will not be considered for award. The award will be made on an all or none basis.

The Government reserves the right to assess the lowest priced quote only. If the lowest priced quote is found to be technically unacceptable, the Government will then assess the second lowest priced quote and continue this process until an award can be made.

The Government intends to evaluate quotations and make an award without conducting “discussions.”

Quotes which merely offer to conduct services in accordance with the requirements of the Government's scope of work will not be eligible for an award. Therefore, the Quoter’s initial quote should contain the best terms from a price and technical standpoint. The Government reserves the right to request revisions that seek additional price discounts, revisions to the technical quote, or clarifications for aspects of the quote. If the Government seeks revisions or clarifications, the Government will provide a reasonable deadline for submission of those revisions/clarifications based on the complexity of the request. The Government reserves the right to request revisions or clarifications from only one or a select number of Quoters, if doing so would be in the public’s interest. The Government may reject any or all quotes if such action is in the public interest; accept other than the lowest quote; and waive informalities and minor irregularities in quotes received.

Prior to award the Government will require written concurrence from the contractor prior to issuance of an executed award.

75N91024-CSS-6904112 Page 4 of 7

This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use the information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s capability. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a synopsis and solicitation may be published. However, responses to this notice will not be considered an adequate response to a solicitation(s).

1.0 TITLE

75N91024-CSS-6904112 Page 5 of 7

Meso Scale Discovery MESO QuickPlex SQ 120MM Reader for performing immunoassays.

2.0 BACKGROUND

The Laboratory of Molecular Biology (LMB) conducts both preclinical and clinical studies developing antibody-based agents, such as immunotoxins, for the treatment of cancer. This research often requires measuring the amounts of these antibody-based agents in the serum or plasma of experimental animals or patients who are receiving treatment in the NIH Clinical Center. One ongoing project in LMB is studying the molecular response of Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia variant (HCLv) patients to the immunotoxin Moxetumomab pasudotox in order to understand mechanisms of treatment sensitivity and resistance. Resistance is often seen in conjunction with the development of antidrug antibodies (ADAs). Therefore, these studies require the measurements of both the immunotoxin drug and ADAs in patient blood.

Immunoassays are used to measure antibodies and antibody-based agents in various fluid samples, including serum and plasma. It is advantageous to use detection systems that are sensitive (able to detect very low levels of antibody), but it is also important that a wide range (from very low to very high) of antibody concentrations can be detected from the same sample.

Finally, it is useful to detect more than one type of antibody in the same sample, avoiding multiple separate assays (especially for precious/limited patient samples).

Electrochemiluminescence Detectors can fulfill each of these three functions.

2.1 BRAND NAME

The MESO QuickPlex SQ 120MM Reader is manufactured and sold solely by Meso Scale Discovery (MSD), a division of Meso Scale Diagnostics, LLC. of Rockville, MD. The instrument is compatible only with microwell plates and immunoassay kits sold by MSD and vice versa. MSD utilizes electrochemiluminescence to detect binding events on patterned arrays including protein drugs and antibodies. There are no other known technologies that enable multiplexed measurement using electrochemiluminescence for detection. There are no other known suppliers that provide an electrochemiluminescence detection system that is not reliant on beads or flow cells, which have a more restricted range of detection. The MSD platform is unique in its method for detection. MSD’s ECL detection utilizes proprietary SULFO-TAG™ labels that emit light upon electrochemical stimulation initiated at the electrode surfaces of MULTI-ARRAY® and MULTI-SPOT® microplates through biomolecular interactions between the analyte and labeled reporter at the surface.

2.2 OBJECTIVE

The MESO QuickPlex SQ 120MM Detector will be used for studying the molecular response of HCL and HCLv patient leukemic cells to Moxetumomab pasudotox treatment to understand mechanisms of treatment sensitivity and resistance. Resistance is often seen in conjunction with the development of antidrug antibodies (ADAs). Therefore, these studies require the measurements of both the immunotoxin drug and ADAs in patient blood. This instrument will also be used to measure the levels of antibody-based immunotoxin and ADAs in clinical samples from HCL and HCLv patients.

75N91024-CSS-6904112 Page 6 of 7

3.0 TYPE OF ORDER

This shall be a firm fixed price purchase order.

4.0 SPECIAL ORDER REQUIREMENTS

4.1 PRODUCT FEATURES/SALIENT CHARACTERISTICS

NCI requires an instrument that can detect electrochemiluminescence, measures multiple antibodies over a wide concentration range, and is small enough to reside on a benchtop. The MESO QuickPlex SQ 120MM Detector has been identified to fulfill these requirements.

The following product features/characteristics are required for this requirement:

• Small footprint, allowing the instrument to fit on a benchtop (space available is 24”x24”)

• Cooled scientific-grade CCD camera and precision lens assembly.

• Able to detect up to 10 different antibodies in a sample using chemiluminescence.

• Exhibits a wide dynamic range (>105) to detect low and high antibody levels from the same sample.

• High sensitivity, with limits of detection as low as 0.05-1 pg/ml

• Rapid read times to increase efficiency.

• Compatible with Meso Scale Diagnostics 96-well plates and QuickPlex plates

• Includes laptop with simple, fast, secure data analysis software.

• Low maintenance: no fluidics to clog and no daily or monthly user maintenance required.

5.0 BRAND NAME PRODUCTS.

5.1 The following Brand Name products have been identified to fulfill these requirements:

Item Product Description Product No. Qty Amount

1 MESO QuickPlex SQ 120MM Reader AI1AA-0 1 2 Shipping n/a 1

Total:

5.2 DELIVERY

Delivery shall be within ninety (90) calendar days of the purchase order award. All shipping/handling (including FOB) and delivery/installation fees shall be included in the quote.

Upon delivery, the Contractor shall notify the respective NCI Technical Point of Contact (TPOC) to schedule installation dates and times. Installation shall occur within one (1) business day of delivery and shall be performed by, or under the direct supervision of, an Original Equipment Manufacturer (OEM) certified technician. Equipment shall be delivered to and installed at the following address:

Delivery will be to the following address:

National Cancer Institute, NIH Building 37, Room 5124 37 Convent Drive Bethesda, MD 20892

75N91024-CSS-6904112 Page 7 of 7

6.0 INSPECTION AND ACCEPTANCE

Pursuant to FAR Clause 52.212-4, all items to be delivered in relation to this award are subject to final inspection and acceptance by an authorized representative of the Government. The authorized representative of the Government is the Technical Point of Contact (TPOC) who is responsible for inspection and acceptance of all services, materials, or supplies to be provided by the Contractor.

7.0 TECHNICAL POINT OF CONTACT

The Technical Point of Contact (TPOC) is responsible for inspection and acceptance of all work in relation to this requirement and will serve as the Governments primary point of contact throughout the duration of the requirement. All efforts must be coordinated with this individual.

Note: The TPOC has limited authority within the Statement of Work. They do not have the authority to commit or obligate Government funds or make changes to the terms and conditions of the purchase order. As such, any changes to the purchase order must be performed by a warranted Government Contracting Officer with appropriate delegated authority to do so.

The NCI Technical Point of Contact (TPOC) will be listed in any resulting purchase order.

9.0 PAYMENT

Payment shall be made after successful delivery, installation, training, and acceptance by the NCI Technical Point of Contact (TPOC).