36C25923Q0409.docx

Sources Sought Notice Sources Sought Notice

GENERAL INFORMATION

SET-ASIDE

Network Contracting Office

NCO 19

6162 South Willow Drive, Suite 300 Greenwood Village CO 80111

POINT OF CONTACT*

Noaa Lanotte Contract Specialist Noaa.Lanotte@va.gov 303-712-5794

NCO19Services1@va.gov

PLACE OF PERFORMANCE

ADDRESS

Rocky Mountain Regional VAMC

Eastern Colorado Health Care System

1700 N. Wheeling Street

Aurora CO

ADDITIONAL INFORMATION

DESCRIPTION

REQUEST FOR INFORMATION / SOURCES SOUGHT SYNOPSIS

The Department of Veterans Affairs Network Contracting Office (NCO) 19, Rocky Mountain Acquisition Center (RMAC) is issuing this sources sought notice as a means of conducting market research to identify parties having an interest in, and the resources to support this requirement for Synthesis and Testing of novel antibiotic compounds for the Rocky Mountain Regional VA Medical Center at 1700 N. Wheeling St, Aurora CO 80045. The result of this market research will contribute to determining the method of procurement. The applicable North American Industry Classification System (NAICS) code assigned to this procurement is 541714 - Research and Development in Biotechnology (except Nanobiotechnology), Small Business Size Standard: 1,000 Employees.

This is a request for information and sources only, which may or may not lead to a future solicitation! This is not a solicitation. This request for capability information does not constitute a request for proposals; submission of any information in response to this market survey is purely voluntary; the government assumes no financial responsibility for any costs incurred. Contractor shall provide all labor, parts, supplies and equipment necessary to perform Synthesis and Testing of novel antibiotic compounds for research study shall include but are not limited to:

Lead Optimization of a Novel Antibacterial Agent Targeting DksA in Gram-negative Pathogens

· Task 1: Synthesis of 23 analogs of lead compound #23 at 10-25 mg scale, following the general scheme shown below.

· Subtask 1.1: Modifications at the left-hand side (LHS): 11 compounds, harboring alternate 5-membered heteroaryl moieties.

· Subtask 1.2: Modifications at the right-hand side (RHS): 6 compounds, introducing substitutions and heteroaryl moieties.

· Subtask 1.3: Modifications in the linker region: 6 compounds, introducing heteroatoms in the linker or modifications of the amide bond.

· Task 2: Primary microbiological profiling.

· Subtask 2.1 The spectrum of activity of the compounds will be determined via testing of the minimum inhibitory concentration (MIC) using a panel of bacterial strains composed of mostly Gram-negative bacteria but also including some Gram-positives to monitor off-target activity.

· Subtask 2.2 Plasma protein binding of active compounds will be assessed by MIC testing in the presence of human serum or albumin).

· Subtask 2.3 Non-specific membrane lysis effects will be assessed via equine erythrocyte (hemolysis) assay.

BASED ON THE RESPONSES TO THIS SOURCES SOUGHT NOTICE, THIS REQUIREMENT MAY BE SET-ASIDE FOR SMALL BUSINESSES OR PROCURED THROUGH FULL AND OPEN COMPETITION, and multiple awards MAY be made. Telephone inquiries will not be accepted or acknowledged, and no feedback or evaluations will be provided to companies regarding their submissions. SUBMISSION INSTRUCTIONS: If your organization can provide these services and is interested in this opportunity, please respond to Noaa Lanotte, Contract Specialist, Department of Veterans Affairs, NCO 19, 6162 South Willow Drive, Suite 300, Greenwood Village, Colorado 80111 or via e-mail at Noaa.Lanotte@va.gov and NCO19Services1@va.gov with a statement describing your capabilities. The capability statement shall include a point of contact, complete mailing address, telephone number, email address, and state the company’s business size status and should address this specific requirement, with appropriate documentation supporting claims of organizational and staff capability. Please be as thorough as possible in your submission. Requests for copies of a solicitation will not be honored or acknowledged. The deadline for responses is Thursday, April 20, 2023 at 10:00 AM Mountain Time.

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