36C24526Q0665_1.docx
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- Solicitation number
- 36C24526Q0665
About this file
This is a Presolicitation Notice from the Department of Veterans Affairs Network Contracting Office (NCO) 05 announcing an upcoming solicitation for the preparation and characterization of specialized liposomal formulations for experimental rheumatoid arthritis treatment. The VA intends to issue a Request for Quote or Request for Proposal (specific type to be determined) for research-grade liposomes incorporating patented joint-targeting technologies. The solicitation number is 36C24526Q0665, with a response date of July 31, 2026, at 9:00 AM Eastern Time. The work falls under NAICS code 325412 (Pharmaceutical Preparation Manufacturing) and Product Service Code AJ13 (R&D-Biomedical, Advanced Development), with the place of performance at the contractor's facility or laboratory.
The contractor must demonstrate capability in custom nanoparticle or liposome formulation using sponsor-specified lipid systems, peptide or ligand functionalization of nanoparticle surfaces, drug encapsulation with documented efficiency, analytical characterization (particle size, zeta potential, PDI, drug loading), LC-MS/MS or HPLC drug quantification, and delivery of research-grade formulations for non-GLP exploratory studies with Certificates of Analysis. All proprietary technical specifications, including the patented lipid composition and ART2 peptide functionalization process, will be released only after execution of a Confidential Disclosure Agreement (CDA) with the VA Technology Transfer Program. The contracting office is located in Perry Point, Maryland (ZIP 21902), with Contracting Officer Robert O'Keefe Jr. serving as the point of contact. Vendors should monitor SAM.gov for formal solicitation release, and the VA will not reimburse any costs associated with responding to this presolicitation notice.
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Presolicitation Notice
Presolicitation Notice
| SUBJECT* |
| Liposome Preparation for Experimental Rheumatoid Arthritis treatment |
GENERAL INFORMATION
| CONTRACTING OFFICE’S ZIP CODE* |
| 21902 |
| SOLICITATION NUMBER* |
| 36C24526Q0665 |
| RESPONSE DATE/TIME/ZONE |
| 07-31-2026 9am EASTERN TIME, NEW YORK, USA |
| ARCHIVE |
| 60 DAYS AFTER THE RESPONSE DATE |
SET-ASIDE
| PRODUCT SERVICE CODE* |
| AJ13 |
| NAICS CODE* |
| 325412 |
| PLACE OF PERFORMANCE |
| Contractor's facility / laboratory |
| POSTAL CODE |
| 20422 |
| COUNTRY |
| USA |
CONTACT INFORMATION
| CONTRACTING OFFICE ADDRESS |
| Department of Veterans Affairs |
VA Maryland Health Care System Contracting Officer (90C) P.O. Box 1000, Bldg. 101, Room 26 Perry Point MD 21902
POINT OF CONTACT*
Contracting Officer Robert O'Keefe Jr.
robert.okeefejr@va.gov
ADDITIONAL INFORMATION
| AGENCY’S URL |
| https://www.va.gov/maryland-health-care/locations/baltimore |
| URL DESCRIPTION |
| homepage |
AGENCY CONTACT’S EMAIL ADDRESS
EMAIL DESCRIPTION
DESCRIPTION
PRE‑SOLICITATION NOTICE
Department of Veterans Affairs Network Contracting Office 05 (NCO 05) Joint‑Targeted Drug Delivery Approach for Arthritis Therapy – Liposome Preparation NAICS: 325412 — Pharmaceutical Preparation Manufacturing PSC: AJ13 — R&D—Biomedical, Advanced Development
**IMPORTANT** Upon completion of market research and release of the solicitation, selected vendors will be required to sign a Confidential Disclosure Agreement (CDA) prior to receiving proprietary materials and full technical specifications.
1. Announcement
The Department of Veterans Affairs, Network Contracting Office (NCO) 05, intends to issue a solicitation for the preparation and characterization of specialized liposomal formulations incorporating patented joint‑targeting technologies. This notice serves as a Pre‑Solicitation Notice only and is issued in accordance with FAR 5.204.
This notice is not a request for quotes or proposals, and no responses are required at this time.
2. Summary of Requirement
The forthcoming solicitation will seek a qualified contractor capable of producing research‑grade liposomes utilizing:
• A patented lipid composition
• A patented joint‑targeting peptide (ART2)
• Encapsulation of an anti‑arthritis drug
• Standard physicochemical characterization of nanoparticle/liposome systems
This work supports VA‑owned intellectual property associated with an experimental drug‑delivery system intended for arthritis therapy. Full technical details, including lipid composition, ratios, and ART2 functionalization methods will be released only after completion of a Confidential Disclosure Agreement (CDA) with the VA Technology Transfer Program.
3. Anticipated Contractor Capabilities
The forthcoming solicitation will require vendors with demonstrated capability in:
• Custom nanoparticle or liposome formulation using sponsor‑specified lipid systems
• Peptide or ligand functionalization of nanoparticle surfaces
• Drug encapsulation and documentation of encapsulation efficiency
• Analytical nanoparticle characterization (particle size, zeta potential, PDI, drug loading)
• LC‑MS/MS or HPLC drug quantification
• Delivery of research‑grade formulations for non‑GLP exploratory studies
• Production of Certificates of Analysis (COA) for liposomal drug systems
4. Security and Intellectual Property Restrictions
The lipid composition and ART2 peptide functionalization process are proprietary and patented by the VA.
Distribution of proprietary information will require:
• Execution of a Confidential Disclosure Agreement (CDA) with the VA Technology Transfer Program prior to release of any technical specifications.
5. Solicitation Release Information
The formal solicitation (Request for Quote or Request for Proposal) is expected to be posted on SAM.gov. The solicitation will include:
• Detailed performance requirements
• Instructions to offerors
• Evaluation criteria
• CDA instructions for accessing proprietary specifications Vendors are responsible for monitoring SAM.gov for updates.
6. Point of Contact
Contracting Officer: Robert O’Keefe Jr.
Email: robert.okeefejr@va.gov
No phone inquiries will be accepted. All questions will be addressed after formal solicitation issuance.
7. Disclaimer
This Pre‑Solicitation Notice does not constitute a solicitation. It does not request proposals or quotes and does not obligate the Government to award a contract. The VA will not reimburse any costs associated with preparation or submission of information in response to this notice.
**IMPORTANT** Upon completion of market research and release of the solicitation, selected vendors will be required to sign a Confidential Disclosure Agreement (CDA) prior to receiving proprietary materials and full technical specifications.
Presolicitation Notice
Presolicitation Notice
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