36C24126Q0748.docx
DOCX document 24 KB Posted
- Attached to
- Q301--Zymo Epigenome Sequencing Services Federal contract opportunity
- Solicitation number
- 36C24126Q0748
About this file
This is a Special Notice documenting the Department of Veterans Affairs' intent to award a sole source contract to Zymo Research Corporation for epigenome sequencing services. The VA Bedford Healthcare System intends to procure Reduced Representation Bisulfite Sequencing (RRBS) services for DNA methylation profiling of 269 post-mortem human choroid plexus tissue samples. The statement of work includes sample handling and quality control assessment, bisulfite conversion, library preparation with QC assessment, sequencing at approximately 30 million read pairs per sample, and downstream analysis including raw data alignment, methylation calling, and genome browser track generation.
The sole source award is justified because the existing dorsolateral prefrontal cortex methylation dataset was previously generated entirely by Zymo Research Corporation for the same VA research study, and introducing a second laboratory for the choroid plexus tissue analysis would create an unresolvable technical confound that would compromise the scientific validity of the planned cross-tissue comparison. Zymo Research Corporation is identified as the only vendor capable of generating comparable data using the same laboratory, personnel, and protocols. A prior Sources Sought Notice (36C241-26-AP-4037) did not identify alternative vendors meeting the requirement. The contracting office is located in West Haven, Connecticut (ZIP code 06516), with Point of Contact Chelsea Cortright. The response deadline is August 21, 2026, at 11:00 a.m. Eastern Time. The Product Service Code is Q301 (Biological/Medical Research), NAICS code 541714 applies with a 1,000-employee size standard, and the contract will be firm-fixed-price. No solicitation will be posted to SAM.gov given the sole source procurement authority under RFO 6.103-1.
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Text version
Special Notice Special Notice
| SUBJECT* |
| Zymo Epigenome Sequencing Services |
GENERAL INFORMATION
| CONTRACTING OFFICE’S ZIP CODE* |
| 06516 |
| SOLICITATION NUMBER* |
| 36C24126Q0748 |
| RESPONSE DATE/TIME/ZONE |
| 08-21-2026 11:00am EASTERN TIME, NEW YORK, USA |
| ARCHIVE |
| 60 DAYS AFTER THE RESPONSE DATE |
| RECOVERY ACT FUNDS |
| N |
| PRODUCT SERVICE CODE* |
| Q301 |
| NAICS CODE* |
| 541714 |
| CONTRACTING OFFICE ADDRESS |
| Department of Veterans Affairs |
Network Contracting Office 1 (NCO-1) Contracting (90C) 950 Campbell Avenue West Haven CT 06516
POINT OF CONTACT*
Contract Specialist Chelsea Cortright Chelsea.Cortright@va.gov
ADDITIONAL INFORMATION
AGENCY’S URL
URL DESCRIPTION
| AGENCY CONTACT’S EMAIL ADDRESS |
| chelsea.cortright@va.gov |
| EMAIL DESCRIPTION |
| chelsea.cortright@Va.gov |
DESCRIPTION
Notice of intent to award a sole source contract. This is not a solicitation.
The Department of Veterans Affairs intends to negotiate a sole source contract with:
ZYMO RESEARCH CORPORATION
17062 Murphy Avenue Irvine, California 92614, United States
MNUYHHMKG8N9
This is not a solicitation. The Department of Veterans Affairs, VA Bedford Healthcare System intends to award a sole source, firm-fixed-price contract to Zymo Research Corporation for Reduced Representation Bisulfite Sequencing (RRBS) services for DNA methylation profiling of 269 post-mortem human choroid plexus tissue samples.
Description of Supplies/Services: RRBS services on 269 post-mortem human choroid plexus tissue samples, including sample handling and QC assessment, bisulfite conversion, library preparation and QC assessment, sequencing (~30 million read pairs per sample), and raw data alignment, methylation calling, and genome browser track generation.
This requirement supports an ongoing VA research study requiring DNA methylation data from choroid plexus tissue that is directly comparable, at the laboratory-batch level, to an existing dorsolateral prefrontal cortex methylation dataset previously generated in its entirety by Zymo Research Corporation for the same study. Introducing a second laboratory to generate the choroid plexus data would create a vendor-of-origin technical confound that is inseparable from the biological comparison the study is designed to detect, and this confound cannot be reliably resolved through statistical correction after the fact. Zymo Research Corporation is the only vendor that can generate this data using the same laboratory, personnel, and protocol as the existing dataset, thereby preserving the scientific validity of the planned cross-tissue comparison.
The contractor will provide the required services. Since the intent is to procure this on a sole source basis, no solicitation will be posted to Contracting Opportunities SAM.gov. A Sources Sought Notice (36C241-26-AP-4037) was previously posted for this requirement; responses received did not identify a source able to meet this specific requirement without introducing the technical confound described above.
The authority for this action is RFO 6.103-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy the Agency's Requirements.
The NAICS code is 541714. The size standard is 1,000 employees. The PSC is Q301.
Interested persons may contact the Contract Specialist by email at Chelsea.cortright@Va.gov regarding this procurement. The determination to conduct a competitive procurement based on responses to this notice is solely within the discretion of the Contracting Officer.
Response must be received by 8/21/26 NLT 11:00am EST.
| *= Required Field |
| Special Notice |
Special Notice
File details come from the government source that posted it. Updated .