25-001407 PD Final.doc

PURCHASE DESCRIPTION

1. Statement of Need and Purpose: The purpose of this acquisition is to purchase a Vibrating Microtome for micro slicing autopsied brain tissues to prepare samples for microscopy analysis.

2. Background Information and Objective:

The National Institute on Aging (NIA) Center for Alzheimer’s Disease and Related Dementias (CARD) works to understand the pathological basis of neurodegenerative diseases. The purpose of the Vibrating Microtome is for the preparation of autopsied brain tissue slices for microscopy analysis to support neurodegenerative disease research within the Center for Alzheimer’s Disease and Related Dementias.

3. Generic Name of Product: Vibrating Microtome

4. Purchase Description:

5. Salient characteristics All deliverables required under this contract shall be packaged, marked, and shipped in accordance with Government specifications. At a minimum, all deliverables shall be marked with the contract number and Contractor name. The Contractor shall guarantee that all required materials shall be delivered in immediate usable and acceptable condition.

Vibrating microtome instrument must be able to provide the following features.

· Capable of slicing tissues, with ≤ 1µm Z-axis deflection

· Include its own z-axis calibration unit

· Include z-axis blade adjust minimizer

· Include blade holder angle to user requirement

· Include set start and stop position from blade travel

· Ability to deploy re-usable zirconium-ceramic blades or stainless-steel blades.

· Include demountable electronically controlled thermo-electric tissue bath cooler

· Capable of adding an optional LED light accessory and scope

· A section thickness step size of 0.001 mm

· A bath table rise & fall speed of 1.0 mm/sec maximum

· A maximum of 19 mm (vertical) travel of bath table

· A minimum cutting head advance speed of -4.0 mm/sec (-1.00 during slicing).

· A maximum cutting head advance speed of +4.0 mm/sec (+1.00 during slicing)

· A cutting head retraction speed of 4.0 mm/sec

· A maximum of 40 mm travel of cutting head.

· A minimum of 50 Hz blade oscillation frequency.

· A maximum of 120 Hz (amplitude dependent) Blade oscillation frequency.

· A frequency step size of 5 Hz

· A minimum blade oscillation amplitude of 0.5 mm (nominal)

· A maximum blade oscillation amplitude of 2.5 mm (nominal)

· An amplitude step size of 0.25 mm (nominal)

· A controlled blade advance at 10microns per sec

· Capable of manual or automatic operation

· Capable of auto programming by storage of first slicing

· Exterior dimensions no larger than 410mm Width x 400mm Depth x 270mm Height (excluding light source and microscope)

· Weight no larger than 33Kg

6. Quantity:

One (1) Vibrating Microtome

One (1) Stainless Steel Blade

7. Delivery Date: 12 months ARO

8. Period of Performance: N/A

9. Option(s): N/A

Version 11-30-2016-1

FAR Part 11—Describing Agency Needs

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