2- BOM POSTING.doc

Ambis sequence 2219307 Michael Goodwin mgoodwin@niaid.nih.gov 301-761-6321

STATEMENT OF WORK

1) BACKGROUND INFORMATION

The Tuberculosis Research Section (TRS) requires the use of a liquid chromatography mass spectrometer (LC-MS and LC-QqQ) to perform experiments in drug discovery, metabolomics, and microsomal stability, dereplication database, pharmacokinetics, structural determination, clinical serum levels and patient care. Many experiments are time sensitive in conjunction with efficacy studies in clinical trials and high throughput screening and requires prompt repair and maintenance upkeep of the Agilent 1100 LC with 1946DSL Mass selective detector and Agilent 11290 Infinity HPLC with 6460 Triple Quadrupole mass detector.

2) PURPOSE AND OBJECTIVES OF THE ACQUISITION

Should the system become inoperable without easy on-site user repair, the system will be nonfunctional while parts and labor are negotiated through AMBIS and available vendors. This will interrupt progress in TRS’s primary research functions.

3) CONTRACTOR REQUIREMENTS:

a) For the LC-MS system, the contractor shall;

i) Provide one preventive maintenance service visit a year that includes replacement of longlife DAD uv bulb and other PM replacement parts.

ii) 2 day response turnaround time for service call requests

iii) Telephone support for diagnosis and repair consultation

iv) Service contract price includes all travel, labor, and parts (except consumable items and items exposed to sample)

v) Service should cover the following components: Mass selective detector G1946D, binary pump G1312A, diode array detector G1315A, thermal column compartment G1316A, fluorimeter G1321A, control module G1323A, autosampler G1329A, thermostat G1330A, degasser G1322A, and chemstation software ver A 10.02

b) For the LC-QqQ system, the contractor shall;

i) provide one preventive maintenance service visit a year. Includes, but not limited to, inspection of system and pump oil; clean source; inspect filter; run diagnostic

ii) 2 day response turnaround time for service call requests

iii) Unlimited number of service calls. Unlimited telephone technical support

iv) Service contract price includes all travel, labor, and parts (except consumable items)

v) Service should cover the following components: G6460C triple quadrupole mass selective detector, G4220A 1290 pump, G1316C Thermal column compartment, G4226A autosampler, G1330B 1290 thermostat , and mass hunter software

4) CONTRACTOR SUPPLIED MATERIALS

service agreement with the above details in section 3 for a period of one year (estimated start time May 13, 2024 to May 12, 2025).

5) GOVERNMENT FURNISHED MATERIALS

Promptly send the contractor a copy of the purchase order or other receipt of funds.

6) REPORTING REQUIREMENTS AND DELIVERABLES

Supply repairs in the mail if user is to make repair.

7) INSPECTION AND ACCEPTANCE

Contact point and receiving of goods from NIH is Michael Goodwin, NIH employee of the Tuberculosis Research Section.