Statement_of_Work.doc

STATEMENT OF WORK

Development of Mass Spectral Libraries of Natural Products

I. BACKGROUND

The National Institute of Standards and Technology (NIST), Material Measurement Laboratory (MML), Biomolecular Measurement Division (BMD) in Gaithersburg, MD is responsible for the development of chemical databases to accomplish NIST’s mission to carry out collection, compilation, critical evaluation, publication and sale of standard reference data in accordance with Public Law 90-396. 90th Congress, H.R. 6279, July 11, 1968.

Chemical databases provide standard reference data for laboratories, both within NIST and to the worldwide scientific community. The Mass Spectrometry Data Center (MSDC), a component of the BMD, is responsible for the development of the NIST/NIH/EPA Mass Spectral Library (Mass Spectral Library) (http://www.nist.gov/srd/nist1a.cfm) and the Automated Mass Spectral Deconvolution and Identification System (AMDIS) (http://chemdata.nist.gov/dokuwiki/doku.php?id=chemdata:amdis).

The development of the Mass Spectral Library and AMDIS includes analyzing data generated by gas chromatography – mass spectrometry (GC-MS) methods.

II. OBJECTIVES/PURPOSE

The Contractor shall assist in the development of AMDIS and the Mass Spectral Library by analyzing data generated by GC-MS.

III. SPECIFIC REQUIREMENTS

Task AUTONUMLGL \* Arabic \e : The Contractor shall examine data from GC-MS experiments that have been previously collected by the MSDC. The Contractor shall focus on data that has been collected using samples prepared from various natural products, including standard reference materials (SRMs) from urine, essential oils, and plant extracts. The goal of such examination shall be to identify the recurrent unidentified spectra (RUS) that repeat across the spectra collected for the natural products.

Task AUTONUMLGL \* Arabic \e : The Contractor shall examine the RUS identified in Task 1 and select high quality spectra as set forth in “The critical evaluation of a comprehensive mass spectral library”, published in the Journal American Society for Mass Spectrometry, 1999, vol. 10, p, 287-299. For the selected spectra, the Contractor shall create data files of the RUS and retention indices in the AMDIS format (http://chemdata.nist.gov/dokuwiki/lib/exe/fetch.php?media=chemdata:amdis.pdf).

Task AUTONUMLGL \* Arabic \e : The Contractor shall perform testing on the AMDIS software to identify errors in the program. Once identified, the Contractor shall correct those errors in the software.

Task AUTONUMLGL \* Arabic \e : The Contractor shall perform quality control on the Mass Spectral Library to ensure that the data meets the quality standards set forth in “The critical evaluation of a comprehensive mass spectral library”, published in the Journal American Society for Mass Spectrometry, 1999, vol. 10, p, 287-299. The Contractor shall also test the software that runs the Mass Spectral Library to identify errors.

Task AUTONUMLGL \* Arabic \e : The Contractor shall prepare and provide a Monthly Status Report (MSR) to the Technical Point of Contact (TPOC) via e-mail. The MSR, at a minimum, shall include (1) a summary of the work performed on each task and (2) future work to be performed on each task. The Contractor shall provide the MSR in MS Word Format, NLT the 10th day of each month after award.

Task AUTONUMLGL \* Arabic \e a. The Contractor shall travel to and attend the following conferences:

(https://www.imss.nl/imsc.html) Rio de Janeiro, Brazil

Task 6b. The Contractor shall prepare and present a poster on RUS in natural products at the ASMS conferences defined in Task 6a.

The Contractor shall provide a draft of each of the posters to the NIST TPOC for review and comment, NLT two weeks prior to the start date of each conference. The Contractor shall implement any requested revisions to each poster prior to presenting.

IV. TRAVEL

All travel shall occur in support of and in accordance with this Statement of Work. All travel shall occur in accordance with the Federal Travel Regulation. All allocable, allowable, and reasonable travel expenses will be reimbursed in accordance with the Federal Travel Regulation.

V. PLACE OF PERFORMANCE

All services shall be performed at NIST’s, Gaithersburg, MD campus during normal business hours, which are Monday through Friday, 7:00 a.m. to 7:00 p.m., with the exception of Federal holidays or other official closures.

VI. PERIOD OF PERFORMANCE

Period of Performance

Base: 9/13/2018 – 9/12/2019

Option Period: 9/13/2019 – 9/12/2020

VII. GOVERNMENT FURNISHED PROPERTY, DATA AND/OR INFORMATION

Any property, data and/or information provided by the Government during performance remains the property of the Government and shall be surrendered to the Government upon completion or termination of this requirement. Likewise, all deliverables generated under this requirement remain the property of the Government.

Post award, the Government will provide the Contractor with all equipment and tools needed in the performance of this requirement. The Government will also furnish the Contractor with an office, furnished with a desk, chair, computer, and a telephone. The Contractor will be granted access to the Mass Spectral Library, AMDIS, and all scientific data of the Mass Spectrometry Data Center.

Space used by the Contractor during performance of services may be used for other purposes during their absences. Items of clothing, personal effects, or equipment cannot be secured by NIST during their absence. The Government will not incur any liability for theft, damage to, or loss of such personal items.

VIII. DELIVERABLES

The Contractor shall perform in accordance with the foregoing task requirements and is responsible for successfully providing all corresponding deliverables as included in the table below. The Contractor shall submit deliverables to the TPOC via e-mail.

Travel to 67th ASMS Conference in Atlanta, GA Option Period:

Travel to 68th ASMS Conference in Houston, TX Travel to 23rd IMSC in Rio de Janeiro, Brazil

June 1-4, 2020

TBD, 2020

67th ASMS Conference Poster Option Period:

68th ASMS Conference Poster

PowerPoint

IX. PERFORMANCE REQUIREMENTS SUMMARY

The Contractor shall submit deliverables to the NIST TPOC via e-mail. The TPOC will provide comments via e-mail on each deliverable within 14 calendar days from receipt if revisions are required. The Contractor shall make any needed changes to each deliverable, and submit each revised deliverable via e-mail, within 14 calendar days from receipt of comments from the TPOC.

X. ATTACHMENT

“The Critical Evaluation of a Comprehensive Mass Spectral Library”, published in the Journal American Society for Mass Spectrometry, 1999, vol. 10, p, 287-299.

XI. CONTRACTOR’S MINIMUM QUALIFICATIONS

The Key Personnel shall have: 1.) B.S., M.S., or Ph.D. degree in Chemistry or Physics with a minimum of 20 credits in physics and/or chemistry, 2.) A minimum of 5 years of experience in analyzing GC-MS data files, 3.) A minimum of 5 years of experience of developing mass spectra libraries and deconvolution software, 4.) A minimum of 3 years of experience in programming in C++, and 5.) A minimum of 2 years of experience identifying RUS.

Education completed in foreign colleges or universities may be used to meet the minimum educational requirement. The Contractor must demonstrate that the foreign education credentials are at least equivalent to the minimum educational requirements above.

XII. GENERAL INFORMATION

Safety: The Contractor is responsible for knowing and complying with NIST safety policies as set forth in the NIST Laboratory Safety Manual, which will be provided to the Contractor within two weeks of the date of the award.

Security: NIST is a restricted campus. An identification badge is required for access for entry into buildings and is shown to the armed Security Police when entering the campus.

Identification Badges: The Contractor shall comply with NIST identification and access requirements. The Contractor is responsible for absences due to expired identification and access documents. The Contractor shall wear a visible identification badge provided by the NIST Security Office. The badge must show the full name, title, and if required by NIST, the words “Contractor” in front. The Contractor shall turn in the NIST identification badge and vehicle pass to the TPOC or Contracting Officer (CO) upon termination of their services under this award.

Vehicle Registration: The Contractor shall register their vehicle(s) with the NIST Security Office to gain access to the campus. A valid driver’s license, Government-furnished civilian ID, proof of insurance and current registration must be presented to the NIST Security Office, at which time a NIST vehicle pass will be issued. The pass shall be displayed as instructed by the NIST Security Office. The Contractor shall follow NIST procedures for removal and turn-in of the vehicle pass upon termination of services under this award.

Media Inquiries: The Contractor shall not respond to any media inquiries. Any inquiries from the media shall be immediately relayed to the TPOC and/or CO. There shall be no interviews, comments, or any other response without the knowledge and approval of the NIST Director.

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