UNSPSC 51452304: Nitisinone

This classification denotes an enzyme inhibitor with the molecular formula C14H10F3NO5, a preparation that US FDA regulates as an active ingredient or moiety under Unique Ingredient Identifier K5BN214699, chemically known as 1,3-cyclohexanedione, 2-(2-nitro-4-(trifluoromethyl)benzoyl)- but generally known as nitisinone, which bears US NIH Compound Identifier 115355. European Medicines Agency schedules Nitisinone in its eXtended EudraVigilance Medicinal Product Dictionary or XEVMPD under Index SUB09313MIG.

World Health Organization schedules nitisinone in its Anatomical Therapeutic Chemical (ATC) Classification. As of Q4 2014, NITISINONE remains the US FDA Preferred Term for this commodity. Nitisinone bears US NLM identifiers UMLS ID C0173083 and NCI Concept Code C61862. SMILES: FC(F)(F)C1CC([N](=O)O)C(C(=O)C2C(=O)CCCC2=O)CC1.

UNSPSC 51452304 Nitisinone is a Commodity code nominally designating a specific pharmaceutical compound, but the recent state and local opportunities tagged under it show little alignment with that scope. The four most recent solicitations posted since January 2026 span naloxone procurement (opioid overdose reversal), therapeutic pharmacy initiatives for direct-to-manufacturer prescription programs, general medical and first aid supplies for emergency response, and multi-source generic pharmaceuticals and OTC products through cooperative purchasing — none of which directly address nitisinone, a rare-disease treatment for hereditary tyrosinemia. The mismatch suggests that state and local procurement offices are using this code as a catch-all for pharmaceutical acquisitions rather than applying it to the specific active pharmaceutical ingredient it nominally describes, or that the code has been misapplied in tagging these opportunities.

The issuing bodies span state health agencies (Texas HHS Commission), county health departments (Seminole County, Florida), municipal fire and rescue services (City of Tampa), and multi-state cooperative purchasing alliances (Minnesota Multistate Cooperative Purchasing Alliance, MMCAP, serving state and local governments across Minnesota and Oregon). Recent activity appears concentrated in Florida and Minnesota, with secondary interest in Texas. Representative recent opportunities include Seminole County's IFB for 1,900 units of naloxone and 800 safe drug deactivation systems annually (due July 26, 2023), the City of Tampa's IFB for medical and first aid supplies to the Fire Department Rescue Division totaling an estimated $700,000 with a certified Small Local Business Enterprise set-aside (due March 13, 2026), and MMCAP's RFP for generic multi-source pharmaceuticals and OTC products through authorized wholesalers (due March 26, 2026). The code shows active procurement volume but little current relevance to nitisinone-specific solicitations; vendors targeting this code should expect to compete for broader pharmaceutical supply contracts rather than specialty rare-disease medications.