UNSPSC 51111610: Methotrexate

This classification denotes a folate antagonist and dihydrofolate reductase inhibitor with the molecular formula C20H22N8O5, a preparation that US FDA regulates as an active ingredient or moiety under Unique Ingredient Identifier YL5FZ2Y5U1, chemically known as poly(imino((1s)-1-carboxy-4-oxo-1,4-butanediyl)), alpha-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-omega-hydroxy- but generally known as methotrexate, which bears US NIH Compound Identifier 4112.

UNSPSC 51111610 Methotrexate is a Commodity code covering the procurement of this specific immunosuppressant and chemotherapy pharmaceutical agent by state and local health agencies. State and local governments buy methotrexate primarily through pharmacy benefit programs, health plan procurement, and direct-to-manufacturer channels serving employee and retiree populations covered by self-insured government health plans and Medicaid programs. The recent activity under this code reflects a shift toward direct contracting models that bypass traditional pharmacy benefit managers and group purchasing organizations, with vendors expected to support negotiated net pricing without rebates and to implement value-based or outcomes-based payment arrangements.

State health agencies—specifically state health and human services commissions—represent the primary issuing bodies soliciting under this code. The Texas Health and Human Services Commission posted a Request for Information (RFI HHS0017013) on April 3, 2026, seeking vendor capabilities for implementing a Therapeutic Pharmacy Initiative Direct-to-Manufacturer Prescriptions program. The RFI targets vendors with experience in direct contracting for self-insured employers and government health plans, flexibility in negotiated net pricing models, and capacity to serve multiple government jurisdictions. The solicitation represents exploratory market intelligence rather than a formal competitive procurement; no award values, budget ranges, or binding timelines are specified, and the state intends to use vendor responses to develop detailed procurement specifications and implementation timelines for subsequent formal solicitations. Activity under this code remains limited to the Texas procurement.