Production Assistance for Cellular Therapies - Cell Processing Facilities (PACT-CPF)

The Production Assistance for Cellular Therapies - Cell Processing Facilities (PACT-CPF) is a master Indefinite Delivery/Indefinite Quantity (IDIQ) contract awarded by the National Heart, Lung, and Blood Institute (NHLBI) to support advanced cellular therapy research. The contract focuses on developing clinical manufacturing protocols and producing novel somatic cell therapies for pre-clinical studies in support of Investigational New Drug (IND) applications. Specifically, the program aims to fund up to eight geographically dispersed Cell Processing Facilities (CPFs) and one Coordinating Center in the United States, with the objective of advancing cellular therapy research in regeneration, tissue repair, and targeted treatments for serious diseases.

The task orders under this IDIQ consistently involve cell manufacturing, process development, and research support services for various cellular therapy initiatives. Prime contractors have included nonprofit research institutions such as Beckman Research Institute of the City of Hope, University of Miami, University of Minnesota, Baylor College of Medicine, and H. Lee Moffitt Cancer Center. Typical task order values range from approximately $150,000 to $1.5 million, with performance periods generally spanning 12-24 months. The contracts are predominantly cost-no-fee and do not utilize small business set-asides, indicating full and open competition. Performance locations are primarily in states with significant medical research infrastructure, including California, Florida, Texas, and Minnesota. The funding source is consistently the National Institutes of Health's National Heart, Lung, and Blood Institute, supporting research into cellular therapies for cardiovascular, blood-related, and other serious medical conditions.