Pharmacology and Toxicology for Therapeutics Program (PTTP)
Ended Master IDIQ Awarded
- Federal agency
-
National Institutes of Health
- Awardees
- 2
- Task orders
- 18
- Obligated
- $18,726,239
Vehicle facts
- Opportunity
-
- NIHNINDS1601 Solicitation number
- Agency
-
- National Institutes of Health Department of Health and Human Services
- Combined task order value
-
- $18,726,239 Current, with exercised options
- $25,620,349 Potential, with all options
- Last date to order 100% complete
- Shared ceiling 11% used
- $174,470,000.00
IDV award and task order details come from SAM.gov/FPDS.
About this vehicle
The National Institutes of Health awarded a Master IDIQ to the National Institute of Neurological Diseases and Stroke on September 13, 2016, to procure pharmacokinetics, toxicology, and safety assessment services for therapeutic candidates, with ordering authority expiring September 12, 2026—approximately one month remaining.
The vehicle is nearing the end of its lifecycle with minimal recent ordering momentum. Eighteen task orders have been awarded since inception, but activity has declined sharply: only one order was issued in 2023, and none since. The most recent task order was awarded July 3, 2023. Combined task-order potential value stands at $25.8 million, with $19 million obligated (73% of potential). Sri International dominates the vehicle, holding 15 of 18 orders representing $24 million in combined potential value; Southern Research Institute holds the remaining 3 orders valued at $1.8 million combined.
Task orders span pharmacokinetic studies in rodent and non-rodent models, IND-enabling GLP toxicology assessments, dose-range-finding studies, and management and operations support. Pricing models vary across cost-plus-fixed-fee, cost-no-fee, labor-hour, and firm-fixed-price arrangements. Notable task orders include a continuous rodent and non-rodent pharmacokinetic assessment to Sri International (ceiling $7.3 million, obligated $2.5 million) and IND-enabling GLP toxicology follow-on work (ceiling $503,901, fully obligated).
Funding splits between the National Institute of Neurological Diseases and Stroke (11 orders, $15.4 million combined potential value) and the National Institute on Drug Abuse (7 orders, $10.5 million combined potential value). All 18 task orders carry no set-aside designation, indicating unrestricted competition.
With only one month of ordering authority remaining and no task orders issued since July 2023, pursuit of this vehicle is not viable for new work. Sri International's overwhelming concentration and the vehicle's imminent expiration make this a watch vehicle only, unless successor IDIQs are anticipated to follow under NIH.
Description
The National Institute of Neurological Diseases and Stroke (NINDS), National Institutes of Health (NIH) has awarded a Master IDIQ for services to assess the pharmacokinetics, toxicology and safety of promising candidates to support their eventual use as therapeutics.
IDV awards
| Awardee | IDV award | Awarded |
|---|---|---|
| Southern Research Institute | HHSN271201600007I | |
| Sri International | HHSN271201600006I |
Latest task orders
Show all 18
Top awardees by obligations
| Rank | Awardee | Obligated | Share |
|---|---|---|---|
| 1 | Sri International | $17,062,451 | 91% |
| 2 | Southern Research Institute | $1,663,788 | 9% |
Top funding agencies by obligations
| Rank | Funding agency | Obligated | Share |
|---|---|---|---|
| 1 | Department of Health and Human Services | $18,726,239 | 100% |
Obligations by fiscal year
| Fiscal year | Obligated |
|---|---|
| FY2026 | -$225,506 |
| FY2025 | -$141,054 |
| FY2024 | $1,149,075 |
| FY2023 | $1,760,450 |
| FY2022 | $1,868,897 |
| FY2021 | $1,198,143 |
| FY2020 | $4,445,852 |
| FY2019 | $4,517,667 |
| FY2018 | $2,854,746 |
| FY2017 | $1,089,034 |
| FY2016 | $208,935 |
Show all 11
Quick answers
What is the PTTP contract vehicle?
Pharmacology and Toxicology for Therapeutics Program (PTTP) is an indefinite delivery, indefinite quantity (IDIQ) contract vehicle run by National Institutes of Health (Department of Health and Human Services), awarded on September 13, 2016.
Which companies hold PTTP?
2 companies hold PTTP's IDV awards, one each. The latest went to Southern Research Institute on September 13, 2016. The awardees whose task orders obligated the most are Sri International and Southern Research Institute.
How much has been spent through PTTP?
18 task orders have been placed under PTTP, obligating $18,726,239.
What is the shared ceiling of PTTP?
PTTP's shared ceiling is $174,470,000; its task orders have used 11% of it.
Which agencies use PTTP the most?
The departments whose task orders under PTTP obligated the most are Department of Health and Human Services ($18,726,239).
How much was obligated through PTTP in fiscal year 2025?
Task orders under PTTP obligated -$141,054 in fiscal year 2025.
On GovTribe
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