Pharmacology and Toxicology for Neurotherapeutics Program (PTNP)

The Pharmacology and Toxicology for Neurotherapeutics Program (PTNP) is a Master Indefinite Delivery/Indefinite Quantity (IDIQ) contract awarded by the National Institute of Mental Health (NIMH) to support preclinical drug development for nervous system disorders. The contract provides comprehensive pharmacological and toxicological research services, focusing on in vitro and in vivo studies that assess the safety, pharmacokinetics, and potential therapeutic properties of experimental neurological compounds. This vehicle enables the systematic evaluation of drug candidates through a range of scientific assessments designed to support Investigational New Drug (IND) enabling studies.

The task orders under this IDIQ consistently involve specialized pharmacological research, with most being Cost Plus Fixed Fee or Cost Plus Award Fee contracts. Typical task orders range from $50,000 to approximately $2 million, with performance periods typically spanning 12-24 months. Frequent research activities include rodent and non-rodent pharmacokinetic assessments, brain level determinations, toxicology studies, metabolite identification, and cardiovascular safety evaluations. While multiple research institutions appear to participate, Southern Research Institute and SRI International are prominently represented in the task order awards. None of the task orders utilized small business set-asides, and the contracts appear focused on advanced scientific research supporting neurotherapeutic drug development across various National Institutes of Health (NIH) programs.