Human Laboratory Paradigms

The Human Laboratory Paradigms Master Indefinite Delivery/Indefinite Quantity (IDIQ) contract vehicle, awarded by the National Institutes of Health (NIH), specifically the National Institute on Alcohol Abuse and Alcoholism (NIAAA), is designed to support research on alcohol use disorder (AUD) through human laboratory studies. The contract enables the development of a clinical research network capable of conducting multiple scientific paradigms on non-treatment seeking alcohol use disorder individuals. These studies aim to examine the potential impact of promising alcoholism therapeutic compounds, serving as a critical translation mechanism between pre-clinical findings and potential clinical trials.

The task orders under this vehicle consistently involve human laboratory paradigms testing, with values ranging from approximately $5,000 to $391,000 and typical durations of 1-3 years. Prime contractors have included prestigious research institutions such as Brown University, Yale University, and the Medical University of South Carolina, all of which have conducted research for NIH agencies including the National Institute of Child Health and Human Development and the National Institute on Alcohol Abuse and Alcoholism. The task orders are consistently issued as cost no-fee delivery orders, with no specific set-aside designations, indicating open competition among qualified research institutions. Performance locations appear to be primarily at the universities' research facilities, with a focus on conducting specialized alcohol use disorder research protocols.