High throughput toxicokinetics (httk)
Ended Indefinite Delivery Contract Awarded Last action
- Contract number
- 140D0420D0003
- Awardee
-
Cyprotex US LLC UEI YNGLSAF57T14
- Awarding agency
-
Interior Business Center
Office of Policy Management and Budget, Department of the Interior
- Task orders
- 7 $2,907,365 obligated
Award facts
- Opportunity
-
- High Throughput Toxicokinetics (HTTK) Pre-Solicitation · 140D0420R0008 · Posted Nov 26, 2019
- High-Throughput Toxicokinetics (HTTK) Award Notice · Posted May 1, 2020
- High-Throughput Toxicokinetics (HTTK) Solicitation · Posted Dec 23, 2019
- High Throughput Toxicokinetics (HTTK) Special Notice · Posted Nov 26, 2019
- Combined order value
- $2,907,365 Current and potential, with all options
- Last date to order 100% complete
- IDV ceiling 22% used
- $13,000,000.00
- Award type
- Single award
- Who can order
- Only the awarding agency
- Funding agency
- Office of Research and Development Headquarters Offices, Environmental Protection Agency
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Set-aside
- No set-aside
- Competition
- Full and Open Competition · 2 offers Negotiated Proposal / Quote
- Pricing
- Firm Fixed Price
- Legislative mandates
-
- Other statutory authority
- Service Contract Inventory FAR subpart 4.17
Award details come from SAM.gov/FPDS.
About this IDV
The Environmental Protection Agency's Office of Research and Development awarded a single-award Indefinite Delivery Indefinite Quantity contract valued at $13 million to Cyprotex US LLC on May 6, 2020, with an ultimate completion date of May 5, 2025. This contract supports the EPA's High Throughput Toxicokinetics program, which enables the agency to rapidly and cost-effectively generate toxicokinetic data on industrial chemicals and environmental contaminants. Cyprotex, a foreign-owned contract research organization headquartered in Framingham, Massachusetts and performing work from its East Watertown, Massachusetts facility, specializes in predictive toxicology and absorption, distribution, metabolism, and excretion research services. The contract was awarded without small business set-aside designation, reflecting Cyprotex's competition based on its specialized scientific capabilities. No set-aside provisions have been applied to any subsequent delivery orders issued under this vehicle.
Under this IDIQ contract, the EPA has issued multiple firm-fixed-price delivery orders totaling over $3.5 million to date, including Task Order #7 valued at $451,818 (awarded December 23, 2024; completion December 29, 2025), a $362,208 order (awarded December 1, 2023; completion January 30, 2025), a $133,690 order (awarded April 20, 2022; completion April 24, 2023), a $92,988 task order (awarded February 13, 2023; completion August 12, 2024), a $64,963 order (awarded January 10, 2022; completion January 9, 2023), a $44,744 order (awarded February 12, 2024; completion February 11, 2025), and an initial $1.756 million task order (awarded May 6, 2020; completion May 5, 2021). Cyprotex's deliverables include comprehensive in vitro assay testing encompassing cytochrome P450 inhibition assays, Caco-2 permeability assessments, network formation assays, and toxicokinetic testing methodologies to evaluate chemical absorption, distribution, metabolism, and potential ecological impacts, supporting the EPA's mission of protecting human health and the environment through data-driven chemical risk assessment.
Task orders
| Task order | Ordering agency | Obligated | Awarded |
|---|---|---|---|
| High throughput toxicokinetics (httk) - task order #7 | Interior Business Center (DO) | $451,818 | |
| EPA -toxicokinetic testing | Interior Business Center (DO) | $44,744 | |
| EPA -toxicokinetic testing | Interior Business Center (DO) | $362,208 | |
| High throughput toxicokinetics (httk) task order #4 | Interior Business Center (DO) | $92,988 | |
| Kwaa TBD EPA -toxicokinetic testing | Interior Business Center (DO) | $133,690 | |
| EPA -toxicokinetic testing | Interior Business Center (DO) | $64,963 | |
| High throughput toxicokinetics (httk) | Interior Business Center (DO) | $1,756,954 |
Transactions
| Action | Obligated | Date |
|---|---|---|
| Close Out | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Supplemental Agreement for work within scope | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Supplemental Agreement for work within scope | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Original award | $0 |
Show all 11
Quick answers
Who was awarded contract 140D0420D0003?
140D0420D0003 was awarded to Cyprotex US LLC by Interior Business Center (Office of Policy Management and Budget) on May 6, 2020.
How much is contract 140D0420D0003 worth?
Orders under 140D0420D0003 have obligated $2,907,365. 140D0420D0003's own ceiling is $13,000,000.
How many orders have been placed under contract 140D0420D0003?
7 orders have been placed under 140D0420D0003, the latest on December 30, 2024.
Which agency awarded contract 140D0420D0003?
Interior Business Center (Office of Policy Management and Budget) awarded 140D0420D0003, with funding from Office of Research and Development (Headquarters Offices).
Who can order from contract 140D0420D0003?
140D0420D0003 is a single award indefinite delivery contract. Only the awarding agency can place orders on it.
Was contract 140D0420D0003 competed?
The extent of competition for 140D0420D0003 was full and open competition. The government received 2 offers.
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