Project Grant S15OD042592
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University $250,000 on September 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire an ASFA Spotter V6.7 HE automated liquid handling system for the Vanderbilt Institute of Chemical Biology High-Throughput Screening Core Facility. The equipment addresses a critical bottleneck in scaling organoid and other three-dimensional culture models for...
- The National Heart, Lung, and Blood Institute awarded $2.609 million to Vanderbilt University Medical Center on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the pathophysiological mechanisms of mitochondrial cyclophilin D acetylation in vascular dysfunction and hypertension through September 29, 2028. The project will define cell-specific pathogenic mechanisms of endothelial and smooth muscle cyclophilin D acetylation in hypertension and vascular...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Vanderbilt University Medical Center a $300,000 Project Grant under the Engineering (47.041) federal grant program. The three-year award, issued on June 1, 2021 and concluding on May 31, 2024, will support collaborative research to understand the effects of flow on smooth muscle cells in an arteriole-sized microchannel. Specifically, VUMC will analyze flow conditions and interactions at the...
- The National Institute of Biomedical Imaging and Bioengineering awarded Vanderbilt University $708,389 on September 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design and implement short interfering RNA (siRNA) conjugates as tools for central nervous system cell-specific gene modulation. The project focuses on developing siRNA conjugates that enable targeted gene knockdown in specific CNS cell types,...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $174,621 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac magnetic resonance imaging (CMR) techniques for monitoring congenital heart disease using ultra-low field (ULF) MRI systems. The recipient will adapt CMR to an inexpensive, unshielded, open-geometry ULF MRI system and apply machine learning techniques to mitigate hardware limitations and...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University $752,875 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the fate and function of regulatory ribosome collisions. The research constructs a high-throughput reporter library to determine the fate of disome-inducing elements—ribosome collision complexes that act as signaling hubs in protein synthesis quality control. The...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University Medical Center a $1.386 million cooperative agreement on February 16, 2026, under the Human Genome Research program (CFDA 93.172) to serve as the Coordinating Center for the MAGEN (ML/AI Tools to Advance Genomic Translational Research) Consortium, which supports the GENEPATH (Genetic Variant Evidence using Novel Tools to Elucidate Pathophysiology: Accelerating...
- The National Institute of General Medical Sciences awarded Vanderbilt University $1.741 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop genetically encoded dual-visible protein tags for molecular-resolution cell imaging. The project addresses the resolution gap between light microscopy and cryo-electron tomography (cryo-ET) by engineering universal protein tags simultaneously visible under both light microscopy and electron...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $224,080 on August 3, 2026, for research into cytokine cargo signaling from extracellular vesicles under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds exploratory research on how extracellular vesicles transport cytokines to mediate immune signaling in inflammation. The work addresses a knowledge gap in understanding how cytokines carried on or within...
- The Defense Health Agency awarded Vanderbilt University Medical Center $524,678 on September 30, 2026, under the Military Medical Research and Development program (CFDA 12.420) to support research on early-onset clear cell renal cell carcinoma as a clinically and genomically distinct variant. The research will run through September 29, 2028, with work performed in Nashville, Tennessee. The project grant is classified as assistance funding through the Department of Defense Health Program and...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded Vanderbilt University Medical Center $210,120 on September 1, 2026, to purchase and install a shielded laminar flow hood for the manufacture of investigational radiopharmaceuticals and molecular imaging agents under the Research Infrastructure Programs (CFDA 93.351). The equipment—a von Gahlen shielded laminar flow hood with included dose calibrator and UV sterilization system—will replace a 15-year-old biological safety cabinet at the Vanderbilt University Institute of Imaging Science's Radiochemistry Core (RCC) facility. The RCC operates an ISO5 environment critical for aseptic operations including final vial assembly, quality control, and dose drawing in clinical research manufacturing. The modernized infrastructure will enable continued compliance with cGMP and FDA regulatory requirements and support the core's role in providing research molecular imaging agents for use on three human PET/CT imaging systems, two pre-clinical PET imaging systems, and other end uses. Researchers at Vanderbilt University, Vanderbilt University Medical Center, the nearby VA, and Meharry Medical College—an HBCU historically black academic health science center—will have access to the facility. The period of performance runs through August 31, 2027, with work performed in Forest Hills, Tennessee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $210.1k | 8/18/26 |