Project Grant RM1DE035304
- This $645,034 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports a research project titled "LEVERAGING WHOLE GENOME SEQUENCING AND FUNCTIONAL GENOMIC CHARACTERIZATION TO IMPROVE NSCLP GENE DISCOVERY." The project aims to integrate genomic data, including whole genome sequencing and polygenic risk scores, to systematically evaluate and validate the contributions of...
- This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a $161,644 multifaceted investigation into speech outcomes following maxillary advancement surgery for individuals with cleft palate. The 5-year study, beginning on July 1, 2025, aims to: 1) investigate anatomical risk factors for post-operative velopharyngeal insufficiency, 2) quantify the relationship...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $320,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Marshfield Clinic, Inc. The project aims to identify genomic regulatory elements involved in the development of oral clefts, a common birth defect. Specifically, the research will 1) identify enhancers that drive gene expression in human embryonic palatal mesenchyme cells, 2) determine which enhancers regulate transcription...
- The University of Missouri at Kansas City (UMKC) received a $313,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The purpose of this 2-year grant, running from July 1, 2025 to June 30, 2027, is to conduct a secondary analysis of whole genome sequencing data from the Gabriella Miller Kids First Orofacial Cleft cohorts to identify genetic variants that impact regulatory elements...
- This federal Project Grant award of $1,608,956.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to generate a single-cell multimodal atlas of human craniofacial development and conduct evolution-driven computational and experimental studies of enhancers involved in human midface development. This research is intended to improve understanding of the genetic...
- This federal Project Grant award of $600,029.00, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which dysregulation of the Ras/MAPK signaling pathway leads to craniofacial and dental abnormalities in Rasopathy syndromes. The awardee, Cedars-Sinai Medical Center, will use a combination of comparative morphometrics, transcriptomic, proteomic, and...
- This federal Project Grant award of $129,420.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research conducted by The Leland Stanford Junior University (Stanford University) to investigate methods for improved cleft palate bone regeneration. The key objectives of the research are to: 1) Identify how differences in skeletal stem cell subpopulations and receptor usage...
- This $295,856 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to identify rare genetic variants associated with orofacial clefts (OFCs). The two key objectives are: (1) identifying craniofacial genes with rare deleterious variants, and (2) identifying craniofacial enhancers with rare deleterious variants. By pinpointing these rare variants, the project seeks to...
- This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR), supports research under the Oral Diseases and Disorders Research program (CFDA 93.121) on the role of primary cilia and the C2CD3 protein in craniofacial skeletal development. The $646,212 award to the Children's Hospital Medical Center in Cincinnati, Ohio will fund experiments to determine if skeletal differentiation is impaired in human induced pluripotent stem cell-derived neural crest...
- The Cooperative Agreement award of $336,748.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) aims to develop and test a caregiver-implemented early speech and language intervention model for toddlers with non-syndromic cleft lip and/or palate (NSCL/P). The project will evaluate the effectiveness of the Caregiver-Implemented Enhanced Milieu Teaching with Phonological Emphasis (EMT+PE)...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,281,274 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute. The grant, titled "Leveraging Advances in Practices and Outcomes in Cleft Care: The LEAP Study", aims to create an inclusive global collaborative to develop a cleft-focused learning health system. The project will focus on the first 10 years of life for children with cleft lip and/or palate, a critical period for treatments and assessments. The collaborative will guide the design, build, and reporting of the LEAP learning health system, which will include a data system with dashboards to track performance metrics across 3 domains: nutrition, psychosocial risk identification, and cleft surgery outcomes. This effort is intended to rapidly improve care for children with cleft conditions by facilitating the translation of evidence-based interventions into widespread implementation across diverse healthcare settings. The grant period runs from August 1, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/29/25 |