The Project Grant award, titled "PROGRAM TO CHARACTERIZE EVOLVING ENDOPHENOTYPES OF DEGENERATION AFTER TRAUMATIC BRAIN INJURY (PROCEED-TBI)", was provided by the Defense Health Agency for $7,956,997.00 with a period of performance from September 30, 2023 to September 29, 2027. The grant supports biomedical research related to the Military Medical Research and Development program (CFDA 12.420), with a focus on characterizing clinically relevant animal models of traumatic brain injury...
This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,283,334.00 to the Morehouse School of Medicine (MSM) to develop and validate a progressive mouse model for Traumatic Brain Injury-related Alzheimer's Disease and Related Dementias (TBI-ADRD). The project aims to systematically screen mouse strains and TBI injury types to identify the optimal model for recapitulating key neuropathological, neurobiochemical, and neurocognitive features of human...
The U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $683,442 Project Grant on September 1, 2023 to The Trustees of the University of Pennsylvania to conduct a 3-year study on "Trajectories of Neuroimaging and Blood-Based Biomarkers After Remote Traumatic Brain Injury and Associations with Dementia Risk." The University of Pennsylvania will collaborate with Mayo Clinic on a sub-award to investigate longitudinal changes in brain...
The National Institute on Aging (NIA) awarded a $3,770,822 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant aims to investigate the relationship between epigenetic aging and patient outcomes after severe traumatic brain injury (TBI). Key objectives include determining if accelerated epigenetic aging is linked to variation in acute and long-term outcomes up to 2 years after severe TBI, and exploring how social determinants of health impact...
This National Institute on Aging (NIA) Project Grant award under CFDA 93.866 Aging Research supports a comprehensive research program led by Trustees of Boston University to investigate the long-term clinical and neuropathological consequences of repetitive head impacts (RHI) across the lifespan, including increased risk for Alzheimer's disease (AD) and related dementias. With total funding of $4,269,339 from June 1, 2025 to May 31, 2027, the project will leverage the world's largest RHI and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $192,737 to Texas Tech University Health Sciences Center (TTUHSC) to investigate the mechanisms by which traumatic brain injury (TBI) leads to age-related diseases. The research aims to determine whether inhibiting the interaction between ubiquitin C-terminal hydrolase L1 (UCHL1) and prostaglandins can mitigate TBI-induced blood-brain barrier disruption, chondroitin sulfate glycosaminoglycan...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,513,622.00 over 5 years to the University of Washington to build a unique open-access biospecimen and data repository for investigating connections between traumatic brain injury (TBI), Alzheimer's disease and related dementias (ADRD), and chronic traumatic encephalopathy (CTE). The key products to be delivered include: Expanding an existing nationwide network of well-characterized...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $102,948.00 to Case Western Reserve University to investigate the link between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The key objectives are to assess how acute TBI induces changes to...
This $158,247 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the cell-specific neurodegenerative potential of mitochondria following traumatic brain injury (TBI). The project aims to study how TBI-induced disruptions in mitochondrial function contribute to the development of Alzheimer's-like neurodegeneration over time. Key objectives include determining injury-induced intracellular and extracellular alterations in...