This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $323,978 to the Child Mind Institute Inc., a non-profit organization in New York, to develop novel tools for integrating brain microstructure and functional dynamics in human and non-human primate research. The key products and services to be delivered through this 3-year award include: Extending the existing BrainBuilder tool to...
This federal Project Grant award in the amount of $798,671 from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) will support a research project titled "Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders". The project aims to develop advanced imaging analysis capabilities to leverage the vast repository of clinical brain MRI scans collected at the Children's Hospital of Philadelphia (CHOP) to identify imaging...
This Project Grant award of $443,931 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to demonstrate accurate quantification of changes in brain morphology using a portable 0.05T magnetic resonance imaging (MRI) scanner. The study plans to acquire densely sampled neuroimaging data over multiple time points, coupled with autonomous control and deep-learning-based super-resolution reconstruction, to yield early, accurate, and...
This $3,085,041 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at the University of Pittsburgh to longitudinally examine brain maturation and its relationship to mental health outcomes in adolescents. The key products and services to be delivered under this 5-year award include using advanced neuroimaging techniques like 7T MRI to measure changes in brain structure, function, and...
This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The National Institute of Mental Health (NIMH) awarded a $11,731,574 Cooperative Agreement under the Mental Health Research Grants program (CFDA 93.242) to the Massachusetts Institute of Technology (MIT) to create comprehensive 3D brain atlases for humans and non-human primates. The goal is to simultaneously map brain-wide function, structure, and high-dimensional features (e.g., proteomic, transcriptomic, spatial, morphological, microenvironment, and nanoscopic information) of cells acquired...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Intelligent Imaging Innovations, Inc. (3i) to develop a commercial instrument for large-scale, all-optical electrophysiology. The goal is to combine advanced optical techniques, including volumetric neural activity imaging and computer-generated holography, to enable simultaneous optical recording and manipulation of neuron activity across multiple brain regions. The...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $1,840,559 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct a multi-year research project focused on characterizing early human brain development. The key objectives of the project are to: 1) investigate the hierarchical organization of the cerebral cortex by analyzing structural and microstructural properties, 2)...
This $392,500 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to investigate the developmental origins of mental illness by studying the structure and function of the human hypothalamus. The project, conducted by the University of California, Irvine, will leverage large-scale archival datasets from the Adolescent Brain Cognitive Development (ABCD) and Healthy Brain and Child Development (HBCD) studies...
This three-year, $3,008,008 project grant from the National Institute of Mental Health will fund research to improve the robustness of neuroimaging findings through exploiting variability in processing pipelines. The Child Mind Institute will conduct the research under the Mental Health Research Grants program. Specifically, the grantee will systematically vary components of independently developed neuroimaging pipelines to generate a broad configuration space of 192 pipelines. They will quantify variability in functional connectivity matrices across configurations and identify the contributions of individual components. Robust estimates of functional connectivity will be constructed by sampling variability across pipelines. Machine learning techniques will also be extended to improve the generalizability of brain-phenotype relationships. The research aims to capture dominant sources of variability in functional neuroimaging to help address the field's reproducibility crisis and enable more robust findings. All contributions will be made publicly available, consistent with open science values.