Project Grant RF1AG096055
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $650,872 Project Grant to The Johns Hopkins University to investigate the bioenergetic, physiological, and gait mechanics mechanisms that contribute to the high energetic cost of walking in older adults. The 5-year project, which began on August 15, 2025, will use clinical, laboratory, and sensor-based assessments to detect changes in health and mobility consistent with the onset and...
- This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Kennesaw State University provides $856,382 to quantify the relationship between daily step counts, body composition, and cardiometabolic risk factors in overweight/obese adults across different age groups. The study aims to develop a regression model that can be used to prescribe physical activity, measured as daily step counts, to predictably improve body composition and reduce cardiometabolic...
- This $423,147 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will fund research to understand the effects of mild cognitive impairment (MCI) and Alzheimer's disease (AD) on gait function and locomotor flexibility. The project will compare split-belt treadmill adaptation, gait performance, and cognitive function between healthy older adults, those with MCI, and those with AD. Longitudinal assessments will track disease...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This Project Grant award of $499,943 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports the development of a novel, unobtrusive device by Aster Labs, Inc. to continuously measure and analyze gait patterns in older Black adults as an early indicator of health decline from Alzheimer's disease and related dementias (ADRD). The device aims to provide medical professionals and caregivers with remote access to these insights to help...
- The National Institute on Aging (NIA) awarded a $333,125 Project Grant under the Aging Research (CFDA 93.866) federal grant program to George Washington University. The grant, which runs from September 17, 2024 to August 31, 2025, will fund the development and validation of artificial intelligence algorithms to predict body composition and physical function in older adults using low-cost 3D optical body scanning technology. The research aims to provide accessible and scalable methods to assess...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- The National Science Foundation Office of Integrative Activities awarded a $117,645 Project Grant to the University of Nebraska under the Integrative Activities federal grant program (CFDA 47.083) for the period of June 1, 2022 through May 31, 2025. The grant funds research to develop new data-driven approaches to characterize differences in the metabolic cost of gait cycle phases between older and younger adults. Investigators will leverage system identification and robotic perturbations to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $405,045.00 to the University of Florida to study the neural mechanisms underlying locomotor adaptation deficits and freezing of gait in Parkinson's disease (PD) patients. The project aims to understand how abnormal neural oscillations in the globus pallidus internus (GPI) disrupt the regulation of human walking in PD. The research will utilize a split-belt treadmill paradigm and record local...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify multi-scale mechanisms contributing to age-related increases in the metabolic cost of walking and decreases in walking speed. The $3,224,215 award to Georgia Tech Research Corp, to be completed by July 31, 2029, will leverage a multi-scale, computational-experimental approach to probe the cellular-to-behavioral mechanisms linking the 'distal-to-proximal' shift in lower-limb joint mechanics to elevated metabolic cost and slower gait speeds in older adults. The research will characterize age-related differences in lower-limb joint mechanics and metabolic cost during ecologically-relevant outdoor walking, using novel sensor technology and machine learning. The project will also examine how age-related changes in musculotendon structure and cell-level efficiency contribute to the observed neuromechanical differences. The findings are expected to provide insights into the multi-scale factors underlying mobility impairments in aging, which could inform the development of targeted interventions to enhance walking function and promote healthy aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 8/8/25 |