Project Grant RF1AG090932
- The National Institutes of Health National Institute on Aging awarded $3,024,000 under the Aging Research federal grant program (CFDA 93.866) to the Massachusetts General Hospital on September 30, 2022 for a project concluding on August 31, 2025. The award will support research into discovering sex-linked genes on the inactive X chromosome that may influence female vulnerability to Alzheimer's disease pathology. The awardee will employ genomic, transcriptomic, and epigenetic analysis to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $5,048,928 to establish the Vanderbilt Alzheimer's Disease Research Center (VADRC) in Nashville, Tennessee. The VADRC aims to characterize the intersection between vascular risk factors and the pathogenesis, manifestation, prevention, and treatment of Alzheimer's disease and related dementias (ADRD). Key products and services to be delivered under this 5-year award include: Establishing an...
- This Project Grant award of $431,750 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to investigate the interaction between biological sex and APOE genotype in modulating Alzheimer's disease (AD) risk. The research will leverage human induced pluripotent stem cell lines with various APOE genotypes and sex chromosome complements to examine how APOE and sex influence amyloid-beta processing, tau hyperphosphorylation, and transcriptional changes...
- This federal Project Grant award of $815,215 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting a multi-modal imaging study to understand sex-based differences in brain circuitry and Alzheimer's disease (AD) pathology. The research, led by Yale University, has two key aims: 1) leveraging a new prospective cohort to test the impact of sex and sex-based factors like reproductive period and APOE genotype on functional brain networks and tau progression in...
- The National Institute on Aging (NIA) has awarded a $640,906 project grant under CFDA 93.866 Aging Research to the University of Wisconsin-Madison to conduct research on "Elucidating Cerebrovascular Disease Pathways to Cognitive Decline with Vascular Neuroimaging." The 5-year project aims to utilize advanced neuroimaging techniques to understand the vascular contributions to cognitive impairment and dementia (VCID), and assess their relationship to Alzheimer's disease proteinopathy....
- This federal Project Grant award, valued at $1,552,000.00 and provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a research study examining the relationship between markers of vascular and immune dysfunction, such as platelet aggregation and neutrophil levels, and their association with dementia risk and increased Alzheimer's disease (AD) biomarkers. The study, conducted by New York University School of Medicine, aims to integrate biofluid biomarker data with...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $851,002 to Arizona State University to conduct a systematic investigation of the genetic contributions of sex chromosomes to Alzheimer's disease (AD). The project will re-align large amounts of next-generation sequencing data from AD clinical cohorts, identify genetic variants on the X and Y chromosomes associated with AD phenotypes, and analyze the contributions of X-Y gene pairs to gene...
- This Project Grant award of $5,949,022, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify novel therapeutic targets for treating cerebral amyloid angiopathy (CAA) and vascular contributions to cognitive impairment and dementia (VCID). The research, led by the Jackson Laboratory with sub-awards to Emory University, Rush...
- This federal Project Grant award of $1,321,304.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify the molecular mechanisms underlying the contribution of cerebrovascular disease (CVD) pathologies to Alzheimer's disease and related dementias (AD/ADRD) in older adults. The award will leverage clinical, pathological, and multi-omics data from the Religious Orders Study and Rush Memory and Aging Project to complement existing dorsolateral prefrontal cortex data...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,531,593.00 to Vanderbilt University Medical Center to conduct research on the role of sex-specific genetic factors in the development and progression of cerebrovascular disease (CVD) within the Alzheimer's disease (AD)-affected brain. The research aims to: 1) identify sex-specific genetic markers of autopsy measures of brain vessel disease, 2) identify sex-specific genetic markers of autopsy measures of vascular brain injury, and 3) characterize how known genetic drivers of CVD affect cognitive decline in a sex-specific manner. This extensive genomic analysis leverages autopsy data from over 9,600 well-characterized participants to advance understanding of the biological and genetic factors contributing to the disproportionate impact of AD on women. The project will run from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.5m | 8/25/25 |