Project Grant R61NS146354
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas Health Science Center at Houston $234,000 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to elucidate novel immunomodulatory mechanisms of neonatal Fc receptor blockade by efgartigimod in a T cell-mediated demyelinating neuropathy model. The award funds research examining how efgartigimod, a recombinant human IgG1 Fc...
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $234,006 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a novel pipeline for antigen discovery in Guillain-Barré Syndrome using single-cell T-cell receptor data and artificial intelligence-based ligand prediction. The project addresses the gap between GBS pathogenesis—driven by molecular mimicry in which...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The University of Texas Southwestern Medical Center on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support investigation of post-viral Guillain-Barré syndrome pathogenesis. The research dissects the immunopathogenic mechanisms underlying...
- The National Institute of Neurological Disorders and Stroke awarded University of California, Los Angeles $236,250 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on aging and T cell senescence in chronic inflammatory demyelinating polyneuropathy (CIDP). The research investigates how aging-associated T cell senescence predisposes to peripheral nervous system autoimmunity. The work tests the...
- The National Institute of Neurological Disorders and Stroke awarded the University of South Carolina $237,254 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a national retrospective cohort study of health care quality and outcomes among Medicare patients with Guillain-Barre syndrome. The recipient will perform a retrospective analysis of traditional Medicare claims and Medicare Advantage encounter data...
- Federal Grant Award Summary Loyola University of Chicago's Health Sciences Campus received a $774,361 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) awarded August 1, 2025, with a completion date of July 31, 2027. The award supports preclinical development of novel site-blocking antisense oligonucleotides (SBAOs) for the treatment of Rett...
- The National Institute of Allergy and Infectious Diseases awarded $423,500 to Loyola University of Chicago Health Sciences Campus on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for Project Grant R21AI190998. The award funds research to define the mechanism of central nervous system inflammation induced by colitis in inflammatory bowel disease models. The recipient will investigate how colitis triggers CNS inflammasome activation, seeking to identify...
- The National Institute of Neurological Disorders and Stroke awarded the University of Illinois $528,643 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate inhibition of specific kinases in the p38 MAPK pathway module as a potential treatment for genetic forms of amyotrophic lateral sclerosis (ALS). The project focuses on axonal degeneration, an early pathological event in ALS. Prior research documented...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded a cooperative agreement to The Johns Hopkins University for $749,720 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding supports development and preclinical testing of a sustained-delivery insulin-like growth factor 1 (IGF-1) therapeutic for...
- Federal Grant Award Summary Research Triangle Institute (RTI International) received a $547,846 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. The award supports research focused on the optimization and characterization of small molecule GPR17 (G protein-coupled receptor 17) antagonists for...
The National Institute of Neurological Disorders and Stroke awarded Loyola University of Chicago Health Sciences Campus $342,420 on August 21, 2026, under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to conduct preclinical development of FGTI-2734, a prenyltransferase inhibitor, as a potential therapeutic for acute inflammatory demyelinating polyneuropathy (AIDP), the Guillain-Barré syndrome variant. The R61/R33 IGNITE application funds investigation of FGTI-2734's anti-inflammatory effects in the experimental autoimmune neuritis rat model of AIDP. The R61 phase assesses dose-dependent effects on chemokine release from rat and human blood nerve barrier endothelial cells, investigates acute pharmacokinetics, pharmacodynamics, and toxicity in naive and disease-model rats, and evaluates clinical protection alongside chronic pharmacokinetics, pharmacodynamics, and toxicity in affected animals. The R33 phase evaluates clinical and functional improvement and assesses nerve myelin outcomes. The award targets prenyltransferase inhibition as an alternative to statins, which demonstrate therapeutic benefit in the EAN model but carry muscle toxicity and myelin homeostasis risks precluding clinical translation. Performance occurs at Loyola University of Chicago Health Sciences Campus in Maywood, Illinois, with work completing July 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $342.4k | 8/21/26 |