Project Grant R61NS145289
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $698,390 to the Regents of the University of California at Riverside to conduct research aimed at harnessing innate immunity to control the neuroinflammatory HIV reservoir. The key objectives are to investigate how HIV infection triggers an interferon (IFN) response, how HIV...
- This federal Project Grant award of $194,375.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to determine the impact of persistent HIV in the central nervous system (CNS) on inflammation, brain structure and function, and cognition in people living with HIV. The primary goals are to: 1) Evaluate the specific contribution of HIV in the CNS to...
- This Project Grant award, valued at $184,506.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the dual role of amyloid beta (Aβ) in the neuropathogenesis of HIV-associated neurocognitive disorder (HAND). Specifically, the project aims to explore how Aβ influences HIV entry into the central...
- This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
- This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- The National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, awarded a $1 project grant to the J. David Gladstone Institutes. The grant aims to establish a novel mouse model for studying the impact of HIV and addictive substances on the central nervous system. Specifically, the project will develop a chimeric mouse model with human microglia, neurons, and astrocytes derived from induced pluripotent stem cells. This model will be used to...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the CCL2/CCR2 signaling pathway in modulating HIV-associated ischemic stroke severity and recovery. The $422,125 award, effective from September 18, 2024 to August 31, 2026, will be conducted by the University of Miami. The research aims to...
- The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
- The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression. The model will incorporate peripheral immune cells, glial cells, neurons, brain endothelial cells, and other cell types to study how HIV-1 affects the brain and the associated pathology. The project aims to generate, characterize, and validate iPSC-derived CNS cells and immune cells, as well as establish a perfused HIV-1 blood-brain barrier/CNS model, with the goal of advancing understanding of the complex mechanisms underlying NeuroHIV.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/11/25 |