This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is supporting the development of a first-in-class disease-modifying gene therapy for idiopathic Parkinson's disease (IDPD). The award provides $494,040 to Mark Therapeutics, Inc., a woman-owned small business, to conduct feasibility studies and rigorous preclinical...
This federal Project Grant award of $2,208,982 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the interleukin-13 receptor in Parkinson's disease. The research aims to determine the molecular and cellular mechanisms by which activation of the interleukin-13 receptor alpha 1 (IL-13RA1) can affect the survival of dopaminergic...
This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
This $1,585,446 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a "nano scavenger" diagnostic and therapeutic agent for Parkinson's disease (PD). The research, conducted by Baylor College of Medicine, aims to validate the preclinical potential of a liposome-based agent that binds to oligomeric alpha-synuclein in...
This federal Project Grant award, identified as F31NS137765, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $173,140 grant, awarded on Sep 30, 2024, supports research to investigate the role of neural activity in the degeneration of midbrain dopamine neurons, which is a key pathological process in Parkinson's disease. The project will utilize...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This Project Grant award of $616,200.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will support research to explore the role of neuromelanin accumulation in dopamine neurons and its impact on Parkinson's disease. The primary awardee, the Oklahoma Medical Research Foundation (OMRF), will leverage expertise across three established labs to investigate the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $670,600 to The Johns Hopkins University to conduct research on the role of microglia in Parkinson's disease (PD) cognitive and motor impairment. The research aims to better understand the relationship between a microglial-specific radioligand, [11C]CPPC, and the severity of...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $647,116 to the Regents of the University of Michigan to characterize and target a novel pathway promoting Parkinson's disease (PD) and Parkinson's disease dementia (PDD). The funded research aims to investigate how the interaction between the protease tissue...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, is providing $728,408 to investigate genetic factors that influence susceptibility to pesticide-induced Parkinson's disease. The research aims to biologically validate novel candidate gene variants identified through prior epidemiological studies. The project involves two complementary research approaches: 1) evaluating the effects...