The National Institute on Aging (NIA) awarded a Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regenerative Research Foundation, a non-profit organization, in the amount of $1,931,965 on August 15, 2024. The goal of this award is to generate and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, neural crest pericytes, and microglia to study cerebrovascular interactions in Alzheimer's disease-related dementias (ADRD). The project involves optimizing the integration of the foundation's advanced 3D cerebral cortex organoid and vascular models to create a comprehensive human cell-based cerebrovascular model. This model will be generated from iPSC lines with PSEN1 mutations, a key genetic risk factor for ADRD, and healthy controls. The model will be assessed for reproducibility, cell composition, and ability to recapitulate ADRD pathology, including cerebral amyloid angiopathy. Collaborators will validate the model's face, construct, and predictive validity using techniques like transcriptomics, metabolomics, and evaluating responses to approved antibody therapies. The project aims to deliver a robust, translational human cell model to advance research on ADRD cerebrovascular mechanisms.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.9m | 8/15/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
5042S | The Washington University | Project Grant R61NS138655 | $25.7k | 8/15/24 | |
5042OSUS | The Ohio State University | Project Grant R61NS138655 | $59.0k | 8/15/24 |