Project Grant R61NS138655

Award Date 8/15/24
Completion Date 7/31/27
Dollars Obligated $1.9M
Funding Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
미국 뉴욕
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This National Institute on Aging (NIA) Project Grant award under the Aging Research program (CFDA 93.866) provides $460,625 to the University of Massachusetts Medical School (UMass Medical) from September 30, 2024 to September 29, 2026. The project aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). Researchers will use human induced pluripotent stem cell (iPSC)-based AD models to separately dissect the P53/P21 and P16...
The National Institute on Aging (NIA) awarded a $614,424 Project Grant (CFDA 93.866 - Aging Research) to the University of Washington to conduct research on Alzheimer's disease (AD) pathogenesis. The research aims to use novel explainable AI techniques and induced pluripotent stem cell (iPSC) models to better understand the role of microglia, the brain's immune cells, in the early stages of AD development. The project will integrate the AI approach with deep learning methods to identify subtle...
The National Institute on Aging (NIA), part of the National Institutes of Health within the Department of Health and Human Services, awarded a $2,567,371 Project Grant to The Trustees of Columbia University in the City of New York under the Aging Research program (CFDA 93.866). The grant will fund research from May 1, 2022 to April 30, 2025 to identify cell type-specific autonomous and non-autonomous interactions in Alzheimer's disease (AD) using induced pluripotent stem cell (iPSC) lines from...
This $3,845,311 federal Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of California, San Diego (UCSD) from August 2024 through April 2029. The grant aims to generate age-equivalent neurons from mild cognitive impairment (MCI) patients to investigate early determinants of Alzheimer's disease (AD). Key goals include: Integrating polygenic risk scores for AD with multi-omic analysis of MCI patient-derived...
The National Institute on Aging (NIA) awarded Neucyte Inc., a minority-owned small business, a $500,000 Project Grant under the Aging Research program (CFDA 93.866) to develop a nanoluciferase-based microphysiological systems platform for high-throughput screening of Alzheimer's disease (AD) and AD-related dementia (ADRD) therapeutics. The platform will utilize induced pluripotent stem cell-derived "mini-brain" assembloids to create scalable, reproducible 3D brain models that better...
This Project Grant award, valued at $10,847,672 and funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research on the mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The primary awardee, J. David Gladstone Institutes, will conduct comprehensive studies using human postmortem brain samples, single-cell genomics, and mouse models to elucidate how microglia regulate the balance between vascular...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $147,656 to Emory University to develop the first human locus coeruleus (LC) organoid model to study the role of the LC in the earliest stages of Alzheimer's disease (AD). The key products and services to be delivered include: Validating the structure and function of the LC organoids by comparing them to human and rodent LC neurons. 2) Combining the LC organoids with cortical organoids to define...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...
This $500,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will support Sxrna Technologies, Inc. in developing an organoid toolkit for Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD). The company aims to create a platform for identifying senescent cells in living tissue, which can provide insights into the aging process and enable high-throughput drug screening in complex 3D tissue models. Specifically, the grant will fund...
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The National Institute on Aging (NIA) awarded a Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regenerative Research Foundation, a non-profit organization, in the amount of $1,931,965 on August 15, 2024. The goal of this award is to generate and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, neural crest pericytes, and microglia to study cerebrovascular interactions in Alzheimer's disease-related dementias (ADRD).

The project involves optimizing the integration of the foundation's advanced 3D cerebral cortex organoid and vascular models to create a comprehensive human cell-based cerebrovascular model. This model will be generated from iPSC lines with PSEN1 mutations, a key genetic risk factor for ADRD, and healthy controls. The model will be assessed for reproducibility, cell composition, and ability to recapitulate ADRD pathology, including cerebral amyloid angiopathy. Collaborators will validate the model's face, construct, and predictive validity using techniques like transcriptomics, metabolomics, and evaluating responses to approved antibody therapies. The project aims to deliver a robust, translational human cell model to advance research on ADRD cerebrovascular mechanisms.

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