Project Grant R61HL143324

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $477,290 to Mayo Clinic to investigate the underlying behavioral mechanisms that impact a home-based pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The research aims to determine the associations between patterns of physical activity, sedentary behavior, sleep, and cognitive...

The National Institutes of Health, through the Medical Library Assistance (CFDA 93.879) federal grant program, awarded a $390,852 Project Grant to the Mayo Clinic in Minnesota to conduct a multicenter randomized clinical trial on virtual world-based cardiac rehabilitation. The study aims to promote data-powered cardiovascular health and improve outcomes for cardiac patients, despite the well-established benefits of reduced mortality and improved quality of life from cardiac rehabilitation. The...

This Project Grant award, totaling $136,646, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to Duke University. The funding will support a 5-year observational study to assess sex differences in physical activity (PA) participation and maintenance among individuals enrolled in cardiac rehabilitation (CR) programs. The key objectives are to: 1) identify sex differences in PA participation during and after...

This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $793,184 to Northwestern University to conduct a 2x2 factorial randomized controlled trial. The trial will evaluate the effects of 1) automated transmission of home blood pressure values versus manual transmission, and 2) automatically-generated medical advice to patients via their patient portal versus no automated feedback. The primary outcome is...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University totaling $501,631 will support a study to evaluate how proteomic signatures of frailty respond to a physical rehabilitation intervention in older adults with heart failure with preserved ejection fraction (HFpEF). The key objectives are to: 1) Identify how the circulating proteome changes with physical rehabilitation in the REHAB-HF trial and how these changes relate to...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,415,112 project grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Nebraska Medical Center (UNMC) to evaluate a telehealth-delivered adaptive intervention for improving continuous positive airway pressure (CPAP) therapy adherence and health outcomes in adults with obstructive sleep apnea (OSA). The project aims to: 1) compare effects of motivational enhancement, device support, and...

This Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) provides $725,088 to Rush University Medical Center to conduct a hybrid effectiveness-implementation study to optimize the effectiveness and implementation of COPD self-management treatment. The study will evaluate treatment components including self-management education, physical activity, and inhaler training among 448 individuals with COPD. The primary...

The federal Project Grant award, titled "Adding Inspiratory Muscle Training to Optimize Cardiac Rehabilitation for Heart Failure," is funded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research). The $745,851 grant, awarded on September 1, 2025, supports research aimed at improving exercise tolerance and reducing exertional symptoms in patients with heart failure with reduced ejection fraction (HFrEF). The key objectives are to: 1) test if...

The National Heart Lung and Blood Institute has awarded a $841,555 Cooperative Agreement under the Cardiovascular Diseases Research program (CFDA 93.837) to Harvard Pilgrim Health Care Inc. The "ENHANCE" project aims to integrate a nutrition enhancement within established, evidence-based, federally funded home visiting programs to promote healthier eating patterns and food access for families from lower incomes and underserved communities. The multi-level intervention will be...

This Project Grant award of $195,696.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to co-develop the Active, Nourished, and Empowered Teens (ANET) program, a modular nutrition and fitness intervention for community youth. The project will engage a youth advisory panel to co-design the intervention, which seeks to empower adolescents in their nutrition and physical activity choices while fostering advocacy for nutritional and...