Project Grant R56DE033090

Award Date 9/15/24
Completion Date 9/14/25
Dollars Obligated $612K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02142, USA
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This $612,048 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the role of the lysyl oxidase propeptide (LOX-PP) in regulating macrophage phenotypes and their impact on oral squamous cell carcinoma (OSCC) tumor suppression.

The research aims to characterize the differential effects of wildtype versus variant LOX-PP on macrophage activation, phenotype, and interaction with OSCC cancer cells in vitro. It also seeks to validate the findings in vivo using mouse models and human OSCC tissue samples. Key objectives include determining the ability of wildtype LOX-PP to block FGFR signaling and shift macrophages to a tumor-suppressive phenotype, and investigating how a polymorphic variant of LOX-PP may lose this tumor-suppressive function. This project will provide foundational knowledge on the role of the LOX-PP stromal factor in regulating the OSCC tumor microenvironment.

The grant supports a sub-award to Nova Southeastern University to conduct in vitro studies examining the impact of LOX-PP on macrophage phenotypes and their interactions with OSCC cancer cells. This collaborative research aims to identify specific signaling pathways regulated by LOX-PP that could inform future therapeutic targets for enhancing anti-cancer immunity in OSCC.

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