This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of a blood-based biomarker for characterizing disease progression and therapeutic response in amyotrophic lateral sclerosis (ALS). The awardee, Neurodex Inc., a small for-profit organization, is advancing the validation of an assay for measuring...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,499,212 Project Grant (CFDA 93.853) to Aquinnah Pharmaceuticals, Inc. to develop a novel oral brain-penetrant therapeutic for amyotrophic lateral sclerosis (ALS). The project aims to manufacture, conduct IND-enabling studies, and hold a Pre-IND meeting with the FDA for a new drug candidate designed to slow and potentially reverse the progression of ALS by reducing the accumulation of insoluble, aggregated TDP-43...
The National Institute of Neurological Disorders and Stroke (NINDS), through the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, awarded Cedars-Sinai Medical Center a $227,205 project grant. The grant funds a 5-year research project to (1) use advanced MRI techniques to identify pathological markers associated with upper motor neuron degeneration in the motor cortex of amyotrophic lateral sclerosis (ALS) patients, and (2)...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), provides $1,204,564.00 to Neurologic Solutions Inc. to further develop and validate the EPISCALP EEG analytics algorithm. The goal is to enhance the accuracy of epilepsy diagnosis by leveraging EPISCALP's predictive capabilities to reduce misdiagnosis rates, which currently...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded the University of Oregon a $301,172 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of this 3-year project is to develop scalable fabrication methods for high-density amorphous silicon carbide microelectrode arrays to enable chronic neural interfacing for recording neural activity in studies...
This National Institute of Neurological Disorders and Stroke (NINDS) Project Grant award under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $387,525 to fund research on the role of proton-mediated signaling at the neuromuscular junction in amyotrophic lateral sclerosis (ALS) models. The research aims to investigate how dysregulation of proton concentrations at neuromuscular junctions in susceptible muscle groups may contribute to...
This $318,710 federal Project Grant award from the National Institute of Environmental Health Sciences under the Medical Library Assistance (CFDA 93.879) program aims to develop AI-powered wearable sensors for non-invasive monitoring of Parkinson's disease. The key products and services to be delivered include: Computational methods to identify Parkinson's-specific metabolic and peptide biomarkers in sweat, leveraging multi-omics data analysis. Design, fabrication, and optimization of 2D...
This $498,995 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a highly parallelized interferometric near-infrared spectroscopy (INIRS) platform for the real-time, non-invasive measurement of cerebral blood flow. The research aims to address the limitations of current stroke diagnosis and monitoring techniques...
This $1,018,516 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund the development of advanced multiplexing technologies using innovative dual-channel dark-FRET biosensors. These biosensors will enable dynamic monitoring of alpha-synuclein pathophysiology across complex cellular and in vivo disease models for Parkinson's disease and related synucleinopathies. The award, with a performance period from July 2024 to April 2026, will establish...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding the development of an innovative portable device to rapidly detect and monitor traumatic brain injury (TBI) biomarkers. The $332,122 award to Hemex Health Inc. aims to create a point-of-care diagnostic platform that can quickly analyze whole blood samples to identify elevated...