This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of a blood-based biomarker for characterizing disease progression and therapeutic response in amyotrophic lateral sclerosis (ALS). The awardee, Neurodex Inc., a small for-profit organization, is advancing the validation of an assay for measuring neuron-derived extracellular vesicle-associated TDP43 as a potential diagnostic and patient stratification tool for ALS, as well as for other neurodegenerative disorders like frontotemporal dementia and Alzheimer's disease. The $2,147,016 award, with a period of performance from September 1, 2024 to August 31, 2026, will fund the analytical validation of the biomarker assay and an initial characterization of its ability to distinguish between slow and fast disease progressors in ALS. This project is expected to deliver a fully validated biomarker assay that can be adopted to improve the efficiency and success of clinical trials, as well as enhance patient care and end-of-life planning for individuals with ALS and related neurodegenerative conditions.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.1m | 8/19/24 |