Exploring the parameter space of high frequency magnetic perturbation in manipulating neural excitability and plasticity
Ended Project Grant Awarded Last action
- Award ID
- R44NS127667
- Recipient
-
Magnetic Tides, Inc. UEI CNZJNM3JF2G5
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,620,673
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date
- Originally
- Place of performance
- El Cerrito, CA 94530, USA
Award details come from USAspending.gov.
Description
- Abstract
- Non-invasive brain stimulation (NIBS) has attracted considerable interest in the cognitive neuroscience community, providing an important basic research tool to study brain function, with emerging clinical applications to enhance function in individuals with neurological disorders. Despite this potential, an emerging literature has highlighted concerns regarding the reliability and robustness of transcranial electric stimulation (TES), the primary NIBS method used to induce changes in brain plasticity through the application of subthreshold stimulation. These problems are likely related to the fact that TES systems can only induce modest electrical fields (E-FIELD) at the cortical surface given that safety/tolerance issues limit the intensity of TES stimulation that can be delivered at the scalp. We developed a radically new NIBS approach, one in which subthreshold modulation of neural excitability is brought about via oscillating magnetic fields at KHZ frequencies. This system, referred to ktmp (KHZ transcranial magnetic perturbation) significantly increases the range of subthreshold E-FIELD induction, and through modulation of the envelope of the KHZ carrier frequency, can impose E-fields at physiological relevant frequencies. The three-year funding period will be used to conduct testing with human participants to assess the tolerability and efficacy of the system in producing changes in cortical physiology and behavior. If our expectations are confirmed, this system will introduce a powerful new method for modulating neural excitability and as such, provide clinicians with a promising new intervention in the treatment of neurological disorders.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $49,750 | |
| Amendment | $49,750 | |
| Amendment | $99,011 | |
| Amendment | $103,750 | |
| Amendment | $0 | |
| Amendment | $103,750 | |
| Amendment | $91,694 | |
| Amendment | $999,584 | |
| Amendment | $97,500 | |
| Amendment | $97,500 | |
| Amendment | $123,670 | |
| Amendment | $999,584 | |
| Amendment | $902,565 | |
| Original award | $902,565 |
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Quick answers
Who received award R44NS127667?
R44NS127667 was awarded to Magnetic Tides, Inc. by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 15, 2022.
How much is award R44NS127667 worth?
$4,620,673 has been obligated on R44NS127667.
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