Project Grant R44NS127667
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $557,588 to Magnetic Tides, Inc. to develop an advanced non-invasive brain stimulation system. The project aims to build upon the company's innovative "Kilohertz Transcranial Magnetic Perturbation" (KTMP) technology to create a two-coil KTMP system. This new system will enable the simultaneous stimulation of two cortical brain...
- This $1,651,499 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will be used to assess the proof-of-mechanism for the efficacy of a novel non-invasive brain stimulation method called Kilohertz Transcranial Magnetic Perturbation (KTMP) in improving anhedonia, a core symptom of major depressive disorder (MDD). The 3-year award to Magnetic Tides, Inc., a for-profit company in El Cerrito, CA, will focus on...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research into the use of theta burst stimulation (TBS) to modulate hippocampal-cortical rhythms in schizophrenia. The $160,272 award to The Leland Stanford Junior University, covering the period from June 1, 2025 to May 31, 2027, will explore the use of invasive and non-invasive brain stimulation techniques to understand how TBS can influence...
- This Project Grant award of $777,016.00 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the synaptic mechanisms of continuous theta burst stimulation (CTBS) in the treatment of depression. The project aims to investigate whether CTBS reduces excitation via N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) and/or enhances inhibition via gamma-aminobutyric acid receptors (GABARs) in...
- The federal Project Grant award R21NS137987, in the amount of $427,625.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of Iowa to investigate whether the Transcranial Magnetic Stimulation (TMS)-evoked potential (TEP) in EEG recordings can serve as a non-invasive measure of cortical excitability during...
- This $500,000 project grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems Engineering program will fund research into magnetoelectric nanoparticles as multi-field controlled devices for wireless brain stimulation. Led by researchers at the University of Miami, the three-year project aims to experimentally study the feasibility of using magnetoelectric nanoparticles to achieve wireless deep brain stimulation with sub-millimeter spatial resolution in...
- This federal Project Grant award of $346,500.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), supports research aimed at selectively targeting and modulating cognitive control functions in the brain using transcranial electrical stimulation (TES). The research will measure the effects of spatiotemporally optimized TES on neural...
- The National Institute of Mental Health (NIMH) awarded Ampa Inc., a $1,199,261 project grant under the Mental Health Research Grants program (CFDA 93.242) to develop a next-generation Transcranial Magnetic Stimulation (TMS) system that improves upon current FDA-approved TMS treatments for depression. The key innovations of this system include: (1) precision TMS targeting based on neurocardiac response signals instead of functional MRI, (2) a camera and scalp cap system for neuronavigation rather...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- The National Institute of Mental Health (NIMH) awarded a $830,409 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, to develop novel software and computational techniques that integrate real-time navigated electric-field mapping and source-space electroencephalogram (EEG) analysis during transcranial magnetic stimulation (TMS) to improve the accuracy of targeting and dosimetry for...
EXPLORING THE PARAMETER SPACE OF HIGH FREQUENCY MAGNETIC PERTURBATION IN MANIPULATING NEURAL EXCITABILITY AND PLASTICITY. - PROJECT SUMMARY/ABSTRACT NON-INVASIVE BRAIN STIMULATION (NIBS) HAS ATTRACTED CONSIDERABLE INTEREST IN THE COGNITIVE NEUROSCIENCE COMMUNITY, PROVIDING AN IMPORTANT BASIC RESEARCH TOOL TO STUDY BRAIN FUNCTION, WITH EMERGING CLINICAL APPLICATIONS TO ENHANCE FUNCTION IN INDIVIDUALS WITH NEUROLOGICAL DISORDERS. DESPITE THIS POTENTIAL, AN EMERGING LITERATURE HAS HIGHLIGHTED CONCERNS REGARDING THE RELIABILITY AND ROBUSTNESS OF TRANSCRANIAL ELECTRIC STIMULATION (TES), THE PRIMARY NIBS METHOD USED TO INDUCE CHANGES IN BRAIN PLASTICITY THROUGH THE APPLICATION OF SUBTHRESHOLD STIMULATION. THESE PROBLEMS ARE LIKELY RELATED TO THE FACT THAT TES SYSTEMS CAN ONLY INDUCE MODEST ELECTRICAL FIELDS (E-FIELD) AT THE CORTICAL SURFACE GIVEN THAT SAFETY/TOLERANCE ISSUES LIMIT THE INTENSITY OF TES STIMULATION THAT CAN BE DELIVERED AT THE SCALP. WE DEVELOPED A RADICALLY NEW NIBS APPROACH, ONE IN WHICH SUBTHRESHOLD MODULATION OF NEURAL EXCITABILITY IS BROUGHT ABOUT VIA OSCILLATING MAGNETIC FIELDS AT KHZ FREQUENCIES. THIS SYSTEM, REFERRED TO KTMP (KHZ TRANSCRANIAL MAGNETIC PERTURBATION) SIGNIFICANTLY INCREASES THE RANGE OF SUBTHRESHOLD E-FIELD INDUCTION, AND THROUGH MODULATION OF THE ENVELOPE OF THE KHZ CARRIER FREQUENCY, CAN IMPOSE E-FIELDS AT PHYSIOLOGICAL RELEVANT FREQUENCIES. THE THREE-YEAR FUNDING PERIOD WILL BE USED TO CONDUCT TESTING WITH HUMAN PARTICIPANTS TO ASSESS THE TOLERABILITY AND EFFICACY OF THE SYSTEM IN PRODUCING CHANGES IN CORTICAL PHYSIOLOGY AND BEHAVIOR. IF OUR EXPECTATIONS ARE CONFIRMED, THIS SYSTEM WILL INTRODUCE A POWERFUL NEW METHOD FOR MODULATING NEURAL EXCITABILITY AND AS SUCH, PROVIDE CLINICIANS WITH A PROMISING NEW INTERVENTION IN THE TREATMENT OF NEUROLOGICAL DISORDERS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/16/25 | ||
| Not listed | $0 | 7/11/25 | ||
| Not listed | $0 | 7/11/25 | ||
| Not listed | $49.8k | 6/12/25 | ||
| Not listed | $49.8k | 6/12/25 |