This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,276 over 5 years to the University of California, San Diego (UCSD) to conduct research on predicting outcomes for epilepsy surgery. The project aims to use functional MRI (fMRI) and advanced statistical/machine learning methods to identify associations between brain network...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $690,763 to Brigham & Women's Hospital Inc. to research optimizing neuromodulation therapies for epilepsy. The project aims to identify factors that determine patient response to responsive neurostimulation (RNS), focusing on connectivity, stimulation timing, and background...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), provides $1,204,564.00 to Neurologic Solutions Inc. to further develop and validate the EPISCALP EEG analytics algorithm. The goal is to enhance the accuracy of epilepsy diagnosis by leveraging EPISCALP's predictive capabilities to reduce misdiagnosis rates, which currently...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $438,836 to The Trustees of the Stevens Institute of Technology under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to develop a unified paradigm using simultaneous multimodal measurement of scalp EEG and intracranial EEG (iEEG) signals to estimate the electrophysiological networks of the whole brain....
This $148,956 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop scalable methods for quantifying epileptic networks and guiding epilepsy surgery. The primary objectives are to: (1) develop standardized quantitative methods to analyze structural imaging, intracranial EEG (IEEG), and clinical data across...
This Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $830,409 to Brigham & Women's Hospital Inc. to develop novel software and computational techniques that integrate real-time navigated electric-field mapping and source-space electroencephalogram (EEG) analysis during transcranial magnetic stimulation (TMS) treatments. The goal is to improve the accuracy of targeting and dosimetry for individualized patients to enhance...
This Project Grant award of $535,416 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop a technological toolkit that enables noninvasive mapping of ionic activity in the brain of mice. The key products and services to be delivered under this 5-year grant include: Developing a voltage-sensing nanoprobe comprising indocyanine green (ICG) dye...
The National Science Foundation awarded a $550,000 Project Grant to Northeastern University under the Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a smart seizure prediction system using AI-enabled implantable sensor networks. The system will use embedded artificial intelligence algorithms to enable in-situ medical inference for patients with neurological disorders not treatable with antiepilepsy medications. Northeastern University will develop the...
This $427,625 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to evaluate the use of hyperpolarized 13C magnetic resonance imaging (HPMRI) as a novel diagnostic tool for identifying epileptic tissue. The research aims to: 1) Use a rat model of temporal lobe epilepsy to explore the ability of [1-13C]pyruvate HPMRI to...
This federal Project Grant award of $657,958, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate the cellular and network mechanisms underlying epileptic activity and seizures, as well as investigate the neuronal impact of neurostimulation for treating drug-resistant epilepsy. The 5-year award to Trustees of Boston University...
SOURCERER IC: A WEB-BASED INTEGRATIVE MULTI-MODAL WORKFLOW FOR EPILEPSY SURGICAL PLANNING - ABSTRACT THE OVERARCHING GOAL OF THIS PROJECT IS TO CREATE SOFTWARE THAT IMPROVES THE USE OF INTRACRANIAL EEG TO QUALIFY PATIENTS WITH MEDICATION-RESISTANT EPILEPSY FOR NEUROSURGERY. ONE MILLION PEOPLE IN THE US SUFFER FROM CONTINUAL SEIZURES THAT ARE NOT CONTROLLED BY MEDICATION. THE CURRENT ESTIMATE IS THAT HALF OF THESE COULD BE TREATED EFFECTIVELY BY SURGICAL RESECTION OF THE EPILEPTIC CORTICAL TISSUE, AND YET THE MAJORITY OF THEM WILL NOT RECEIVE THE SURGERY (ENGEL & WIEBE, 2012). THERE ARE 200 COMPREHENSIVE EPILEPSY CENTERS IN THE US THAT ARE CERTIFIED TO PROVIDE BOTH THE EPILEPSY RESECTION AND THE MULTIMODAL PRESURGICAL EVALUATION (CLINICAL SEMIOLOGY, NEUROPSYCHOLOGICAL ASSESSMENT, EEG, MRI, PET, AND INTRACRANIAL OR ICEEG). A PROBLEM FOR THIS EVALUATION IS THE SOFTWARE FOR INTEGRATING THE MULTIPLE IMAGING AND ASSESSMENT MODALITIES IN THE PRESURGICAL WORKUP TO ALLOW CONFIDENCE IN THE NEUROSURGICAL PLAN. THE LOCALIZATION OF THE ICEEG ELECTRODES IS OFTEN PROBLEMATIC BECAUSE OF BRAIN SHIFT (MOVEMENT AND DEFORMATION OF THE BRAIN FROM THE PREOPERATIVE IMAGING TO THE POSTOPERATIVE CT USED FOR ELECTRODE POSITION IMAGING). WITH RECENT ADVANCES IN DENSE ARRAY EEG (DEEG) WITH INDIVIDUAL HEAD CONDUCTIVITY MODELS, ELECTRICAL SOURCE IMAGING CAN PROVIDE NONINVASIVE ESTIMATES OF THE SEIZURE ONSET ZONE, WHICH COULD THEN GUIDE MORE FOCUSED AND EFFECTIVE ICEEG PROBES, AND POTENTIALLY MORE CONFIDENT AND LIMITED NEUROSURGICAL RESECTIONS. THE PRESENT SBIR RESEARCH BUILDS ON OUR EXTENSIVE EXPERIENCE WITH ICEEG ELECTRODE LOCALIZATION, MULTIMODAL NEUROIMAGE REGISTRATION, DEEG SOURCE IMAGING, AND USER INTERFACE DESIGN TO CREATE SOURCERER IC, A SOFTWARE PLATFORM OPTIMIZED FOR BRINGING MULTIPLE FORMS OF EVIDENCE TO INTERPRET ICEEG MEASURES AND IMPROVE THE LOCALIZATION OF THE SEIZURE ONSET ZONE. THE KEY INNOVATIONS OF THIS PROJECT ARE: THE INTEGRATION OF MULTIMODAL NEUROIMAGING DATA (MRI, DWMRI, FMRI, PET) REGISTERED PRECISELY WITH STRUCTURAL MRI IN A DICOM FORMAT FOR EXPORT TO THE NEUROSURGEON'S NEURONAVIGATOR SOFTWARE; THE CAPACITY FOR NONINVASIVE DEEG SOURCE LOCALIZATION OF SPIKES AND SEIZURE ONSET WITH INDIVIDUAL HEAD CONDUCTIVITY MODELS IN PREPARATION FOR ICEEG ELECTRODE PLACEMENT (AS VALIDATION RATHER THAN EXPLORATION); THE CORRECTION OF BRAIN SHIFT DUE TO SURGICAL IMPLANTING OF ICEEG ELECTRODES BY REGISTERING THE POSTOPERATIVE CT TO THE PREOPERATIVE MRI; AND PERHAPS MOST IMPORTANTLY, THE INTEGRATION OF ALL COMPONENTS OF THE PRESURGICAL WORKUP WITHIN AN INTUITIVE AND USABLE SOFTWARE WORKFLOW WITH FULL QUALITY SYSTEM REGULATION AND VALIDATION FOLLOWING FDA GUIDELINES. SOURCERER IC WILL BUILD ON THE MANY YEARS OF EXPERIENCE WITH YALE'S BIOIMAGE SUITE, SUCH THAT PHYSICIANS AND TECHNICIANS ACCESS THEIR COMPONENTS OF THE WORKFLOW THROUGH SECURE WEB INTERFACES, AND THE NETWORKED DATABASE MAINTAINS AND INTEGRATES ALL TRANSACTIONS TO COORDINATE COMPUTATIONAL AS WELL AS DATA RESOURCES FOR EFFICIENT COMPLETION, REVIEW, AND IMPLEMENTATION OF AN OPTIMIZED NEUROSURGICAL PLAN.