This $458,154 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" aims to promote tissue repair and functional recovery after spinal cord injury. The primary awardee, Microcures Inc., is developing a nanoparticle-encapsulated small interfering RNA (siRNA) therapy targeting the Fidgetin-like 2 (FL2) protein to enhance axonal...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a $1,735,024 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Wayne State University on August 15, 2024. The grant funds the development of a non-invasive infrared light therapy and medical device to treat spinal cord injury (SCI). The proposed research aims to reduce reactive oxygen species production and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $184,837 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Ohio State University. The grant, awarded on April 25, 2025, aims to develop a polymer-based drug delivery system for promoting spinal cord repair. The project will focus on optimizing microsphere fabrication for targeted intraspinal delivery of gabapentinoids, a class of drugs that have...
This $391,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop effective therapeutic strategies for spinal cord injury (SCI) by evaluating controlled PTEN deletion and chondroitin sulfate proteoglycans (CSPGs) degradation to promote axon regeneration and functional recovery. The key objectives are to: 1) Temporally evaluate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports development of a novel screening technology to identify FDA-approved drugs that can promote functional recovery in spinal cord injury (SCI). The $411,136 award to the Texas A&M University System Health Science Center will fund a 3-step screening platform using adult cortical...
This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,006,322 in funding to the University of California, San Diego (UCSD) to conduct research on understanding the molecular mechanisms regulating axon regeneration after spinal cord injury. The key products and services to be delivered under this 5-year grant include: 1)...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a $2,354,442 Cooperative Agreement under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Texas at Dallas. The goal is to develop a system for closed-loop vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve recovery of gait in individuals with chronic spinal cord injury (SCI)....
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $151,559 to Rensselaer Polytechnic Institute (RPI) from August 3, 2024 to July 31, 2026. The project aims to develop innovative magnetically responsive drug delivery electrospun fibers to improve regeneration after spinal cord injury (SCI). Specifically, the research will focus...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $437,250 to the University of California, San Diego (UCSD) to conduct pooled in vivo screening of combination gene therapies for enhancing axonal regeneration after spinal cord injury (SCI). The key objectives are to 1) perform CRISPR screening to identify the most effective...