Project Grant R44NS103596

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to develop engineered extracellular vesicles (EVs) for delivering mitochondria and therapeutic proteins to protect the blood-brain barrier (BBB) following ischemic stroke. The $377,875 award to Duquesne University aims to demonstrate that the delivery of...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $221,120 to the University of Texas Health Science Center at Houston (UTHealth) to investigate the potential of adult central nervous system endothelial cells to guide neural progenitor cell migration and enhance neurovascular communication. The research aims to boost...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,218,750 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Trustees of the University of Pennsylvania. The funding supports research focused on developing targeted nanomedicine approaches to deliver therapeutic RNAs, such as interleukin-10 mRNA and ICAM siRNA, to the blood-brain barrier in order to restore its function and reduce inflammation...

This $4.4 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into developing a non-invasive stem cell-derived extracellular vesicle therapy for Alzheimer's disease. Over a three-year period from August 2022 to July 2025, researchers at Texas A&M University Health Science Center will test the hypothesis that intranasal administration of extracellular vesicles generated from human-induced pluripotent stem...

The U.S. National Institute on Aging (NIA) awarded a $506,451 Project Grant (CFDA 93.866 - Aging Research) to 3P Biotechnologies, Inc., a for-profit biotechnology company, to develop a targeted exosomal delivery system for small interfering RNA (siRNA) therapeutics to mitigate neuroinflammatory diseases such as Alzheimer's disease. The project aims to optimize the delivery of siRNA against the inflammatory regulator NF-kB using folic acid-functionalized exosomes derived from bovine colostrum....

This $274,218.64 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to Brandeis University will support research into the mechanisms underlying exosome release from neurons. The grant aims to determine how exosomes are generated from the endosomal system in neurons and explore neuronal exosome and endosome biology in an animal model. The grantee will manipulate the ESCRT and MUNC13-4/RAB11 pathways to investigate endosomal dynamics...

The University of Pittsburgh has been awarded a $428,400 federal Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study the role of the astrocytic sodium bicarbonate transporter NBCE1 in regulating blood-brain barrier (BBB) integrity during ischemic stroke. The project aims to investigate whether pathological activation of NBCE1 in astrocyte endfeet contributes to...

This Project Grant award, valued at $469,500.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award supports research to develop mitochondrial-targeting exosomes (MTEs) carrying anti-inflammatory microRNAs (MTE-miRNAs) as a novel treatment for neuroinflammation, a condition linked to neurodegenerative diseases. The project aims to:...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $481,617 to Louisiana State University Health Sciences Center New Orleans to conduct research on neuroprotective lipid mediators and their potential to protect the penumbra region in experimental ischemic stroke. The key objectives are to: 1) Test the hypothesis that the...