Project Grant R44MH142142
- The National Institute of Mental Health (NIMH) awarded a $557,588 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Magnetic Tides, Inc. in California. The project will develop a novel two-coil kilohertz transcranial magnetic perturbation (KTMP) system for non-invasive brain stimulation. This advanced system will enable frequency-specific manipulation of neural activity at two cortical points simultaneously or within a single subcortical area, achieving stimulation...
- This Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research into the synaptic mechanisms of continuous theta burst stimulation (cTBS) in the treatment of depression. The $777,016 award, active from July 1, 2025 to April 30, 2030, will be conducted by the McLean Hospital Corporation in Belmont, MA. The research aims to elucidate the synaptic mechanisms underlying the inhibitory effects of...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $1,199,261 to Ampa Inc. to validate a next-generation Transcranial Magnetic Stimulation (TMS) system for the scalable, personalized treatment of depression. The key innovations include: (1) precision TMS targeting based on neurocardiac response signals instead of fMRI, (2) camera-based neuronavigation instead of fMRI-based stereotaxy, and (3)...
- The National Institute of Mental Health (NIMH) awarded a $830,409 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Brigham & Women's Hospital Inc. The grant will fund the development of novel software and computational techniques that integrate real-time navigated electric-field mapping and source-space electroencephalogram (EEG) analysis during transcranial magnetic stimulation (TMS) to improve the accuracy of targeting and dosimetry for individualized...
- The National Institute of Mental Health (NIMH) awarded a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Emory University to identify patients with true treatment failure for major depressive disorder (MDD) who may benefit from earlier referral to alternative treatments like transcranial magnetic stimulation, ketamine, and vagus nerve stimulation. The project aims to use trajectory classification methods to empirically separate partial response from true...
- This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support a study to investigate the mechanistic relationship between brain circuit function and negative valence system behaviors in treatment-resistant depression. The $514,178 award, effective July 1, 2025 through April 30, 2030, will employ low-intensity focused ultrasound (LIFU) to noninvasively and reversibly modulate deep brain circuits in...
- The federal Project Grant award titled "Optimized Methods for Measuring Brain Excitability in Depression" was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $784,096 award, with a project period from May 1, 2025 to February 28, 2030, will support research to investigate how adjusting transcranial magnetic stimulation (TMS) parameters affects neural activity, optimize a TMS-based approach to improve...
- This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $638,872 to The Feinstein Institutes for Medical Research to conduct research on "Elucidating Reward Network Modulation in Medial Forebrain Bundle Deep Brain Stimulation for Treatment Resistant Depression". The goal is to use brain imaging to understand how deep brain stimulation of the medial forebrain bundle impacts the brain's reward processing...
- This federal Project Grant award of $420,519.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to develop temporal interference (TI) methods for non-invasive deep brain stimulation. The project aims to characterize the effects of TI on brain activity and functional connectivity using combined TI and fMRI in human subjects (Aim 1), and then apply TI to the dorsal anterior cingulate cortex to investigate its...
- The National Institute of Mental Health (NIMH) awarded a $498,429 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the Children's Research Institute in Washington, D.C. The purpose of this 2-year grant, with a start date of Apr 1, 2025, is to use state-of-the-art machine learning techniques to analyze a multimodal dataset from over 225 sessions with 105 participants, including concurrent transcranial direct current stimulation (tDCS)-functional MRI data,...
The National Institute of Mental Health (NIMH) awarded a $1,651,499 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Magnetic Tides, Inc. in El Cerrito, CA. The 3-year grant, effective August 18, 2025, will evaluate the efficacy of a novel non-invasive brain stimulation method called Kilohertz Transcranial Magnetic Perturbation (KTMP) for treating anhedonia, a core symptom of major depressive disorder. The project aims to demonstrate that KTMP can modulate neural activity in the brain's reward circuitry to reduce anhedonia symptoms in patients. The research will assess whether KTMP leads to increased ventral striatal activation during reward anticipation and evaluate if these physiological changes are associated with reduced anhedonia.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 8/18/25 |