This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $299,893 to Pascall Systems, Inc. to develop a novel system that combines pre-operative cognitive assessment with Pascall's FDA-cleared wireless EEG technology for intraoperative monitoring. The goal is to enable personalized anesthesia care and effective monitoring of postoperative neurocognitive disorders (PNDs) in elderly surgical patients. The key products and services to be delivered...
This $578,000 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program aims to develop a brain-computer interface (BCI)-based assessment to more accurately identify color vision deficiencies (CVDs) related to Parkinson's disease (PD) compared to existing behavior-based approaches. The research will test the hypothesis...
This $427,625 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the University of Washington aims to develop and optimize two novel blood-based biomarker assays to improve clinical diagnosis and differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA). The key products and services to be delivered under this 2-year grant include: Further development and optimization of a flow cytometry-based assay (APOGEE) to directly quantify...
This Project Grant award of $795,000.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a multi-center randomized clinical trial to develop a Clozapine Decision Support Tool for First Episode Psychosis (FEP) patients. The trial aims to evaluate the efficacy of using three biomarkers - a functional brain scan, and genetic tests for weight gain and agranulocytosis risk - to identify FEP patients who may not respond to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop a portable TMS-EEG device called PRESENCE for bedside detection of covert consciousness in patients with disorders of consciousness due to severe brain injury. The $524,243 award to Intrinsic Powers, Inc. will fund the refinement of the PRESENCE product...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $779,842 to The Mclean Hospital Corporation to conduct a multi-center, randomized clinical trial evaluating whether the use of biomarkers can lead to better outcomes for patients experiencing a first episode of psychosis (FEP). The key objectives are to develop a clozapine decision support tool based on three specific biomarkers: a...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of a remote monitoring system to reduce infections among patients undergoing peritoneal dialysis (PD). The $550,000 award to The Johns Hopkins University aims to develop a medical device that can enable high-frequency, real-time monitoring of cellular biomarkers in dialysate to quickly detect PD-associated infections. The...
The National Institute on Aging (NIA), under the Federal Aging Research Grant Program (CFDA 93.866), awarded a $242,956 Project Grant to the University of Colorado-Denver to support the development and evaluation of a decision aid to improve shared decision-making for older adults with Parkinson's disease and mild cognitive impairment (MCI) considering deep brain stimulation (DBS) surgery. The key objectives of this 5-year project are to: 1) adapt and refine an existing DBS decision aid to...
This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $1,419,954 to support research aimed at advancing Adaptive Deep Brain Stimulation (ADBS) therapy for Parkinson's disease. The key objectives are to: 1) Reduce the complexity and risk of chronic cortical sensing by using subgaleal rather than intracranial...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $898,025 to the University of Cincinnati to evaluate the use of transcutaneous spinal direct current stimulation (tsDCS) to modulate spinal interoceptive pathways (SIPs) and their role in Major Depressive Disorder (MDD) symptoms. The research aims to assess tsDCS-induced changes in laser-evoked potentials (LEPs) as neural markers of SIPs engagement...