Project Grant R44HL182545
- This federal Project Grant award of $159,624.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Vanderbilt University Medical Center (VUMC) to investigate the role of hypoxia-inducible factor (HIF) in promoting alveolar regeneration and functional lung repair for patients with idiopathic pulmonary fibrosis (IPF) and other chronic lung diseases. The research aims to explore how modulating upstream disease mechanisms,...
- This federal Project Grant award of $811,370.00, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to study the role of the Hippo-YAP/TAZ signaling pathway in regulating alveolar epithelial cell regeneration during lung repair. The research aims to determine the critical cellular and molecular mechanisms that facilitate normal alveolar repair and regeneration, with the overarching hypothesis that dynamic,...
- This Project Grant award for $814,387 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to investigate the role of a novel subpopulation of innate lymphoid cells (ILC3s) in lung infections and vascular regeneration. The award recipient, The Trustees of Columbia University, will utilize mouse models, single-cell analysis, and in vitro assays to: Define the tissue niche and response dynamics of lung vascular ILC3s (VILC3s),...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $496,255 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Vivita Technologies, Inc. (Davis, CA) to validate its patented SPEAR Platform™ technology for developing unfixed, immune-compatible, and regenerative xenogeneic biomaterials for transcatheter heart valve replacements. The project aims to produce BARE™ patches derived from porcine pericardium that can avoid immune rejection, integrate with...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the mechanosensitive mechanisms underlying angiogenesis and lung regeneration. The $618,838 award to the Medical College of Wisconsin aims to investigate how mechanical stretching forces control angiogenesis during compensatory lung growth after pneumonectomy. The research will focus on the role of the focal adhesion protein paxillin in regulating...
- This federal Project Grant award for $637,913, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research by the University of Southern California (USC) to investigate the role of "transitional alveolar epithelial cells" in lung development and regeneration. The goal is to better understand the mechanisms underlying the alveolar epithelial cell differentiation process during normal lung development, as...
- This federal Project Grant award, valued at $158,652 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research into the impact of alveolar macrophage senescence in aged donor lungs on post-lung transplant outcomes. The award, with a start date of September 1, 2025 and an ultimate completion date of August 31, 2030, will be carried out by Duke University's Office of Research Administration Division. The research aims to...
- This $166,752 Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at Trustees of Boston University to investigate the signaling mechanisms underlying lung branching morphogenesis. The project aims to combine developmental biology approaches with synthetic biology tools to elucidate the reaction-diffusion patterning that directs the assembly of the elaborate bronchial network in the lung. This work could provide...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $784,227 to The Ohio State University to engineer an oxygen-carrying perfusate for normothermic machine lung perfusion. The project aims to develop an improved lung perfusion solution to better assess and potentially resuscitate damaged donor lungs for transplantation. This is in response to the critical shortage of viable donor lungs, which has led to the...
- This Project Grant award of $279,750 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to enhance the efficiency of generating human vasculature in a pig. The goal is to produce human-porcine chimeras that can serve as an unlimited source of organs, such as hearts, for xenotransplantation. The award recipient, Northstar Genomics, LLC, will compare their proven approach using somatic cell nuclear transfer (SCNT) technology with a new method...
This Project Grant award, funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to advance the development of a bioengineered human lung graft called InspireX Lung. The $1,266,937 grant, awarded to Xylyx Bio, Inc. in collaboration with Vanderbilt University Medical Center, will support obtaining Investigational New Drug (IND)-enabling safety and efficacy data, including first-in-human transplantation studies, for the bioengineered lung graft. The project builds on Xylyx Bio's prior work using a porcine bioreactor to generate transplantable lung grafts from discarded human donor lungs. The goal is to significantly expand patient access to lung transplantation by doubling the utilization rate of donor lungs and potentially eliminating waitlist deaths. The award period runs from Sep 8, 2025 to Jun 30, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/5/25 |